Great Britain Research Articles

Increasing rate of moth species establishment over 120 years shows no deceleration

Abstract Around the world, the number of species establishing outside of their native range has and continues to increase rapidly. Some of these non‐native species are invasive and can cause negative environmental, economic, and social impacts, including declines in native biodiversity. Species can become established either through natural dispersal or with intentional or inadvertent human assistance, but the relative importance of these two modes over time has been little studied. We compiled data on 116 moth species that became established in Great Britain (GB) between 1900 and 2019. We classed each species as either an immigrant, which had colonised naturally, or an adventive, which had colonised through human assistance, and categorised species as feeding on either native or non‐native larval host plants. We found that the rate of moth species establishment has accelerated steadily, at 21% increase per decade, showing no signs of saturation. Immigrant species showed a steady rate of establishment between 1900 and 1935, followed by a significant acceleration of 11% per decade thereafter, which most closely matches the rate of immigrants that feed on native host plants. Immigrants that feed on non‐native host plants show a slower increase across the whole time period compared to all species, of 13% per decade. Adventive species show a similar rate of increase in establishment to all moth species, at a rate of 26% per decade. Adventives on non‐native host plants show a similar trend, but we find evidence for a post‐1980s increase in the rate of establishment for adventives that feed on native host plants. Our results indicate that the global case for enhanced biosecurity, around both the monitoring of natural colonisations and for the horticultural trade, remains very strong as non‐native colonisations are showing no signs of saturation with ongoing environmental and economic change.

Blood transfusion in the Caribbean: Historical perspective in the context of Trinidad and Tobago.

To compare the historical development of blood transfusion in Britain and a former British West Indian colony. International transfusion bodies recommend national coordination and exclusively voluntary non-remunerated donation as essential pre-requisites for blood safety. These ideals have been achieved in high-income countries including Great Britain, the United States of America and Canada. However, most West Indian countries have fragmented, hospital-based blood services that rely on family replacement and remunerated donors. Comparative historical analysis of blood transfusion service development in Great Britain and Trinidad and Tobago was undertaken to provide insight into their dichotomous development and inform policy decisions to bridge the gap between the two types of transfusion service. The British National Blood Transfusion service was based on voluntary non-remunerated blood donation from its inception but achieved national coordination over 50 years that included a period of regional control during which incoordination contributed to a tainted blood scandal. Failure to establish community voluntary non-remunerated donation in Trinidad and Tobago during the colonial period, before independence in 1962, allowed regionally-controlled family replacement and remunerated blood donation to become entrenched then perpetuated by path dependence. A university-led programme has recently used historically-proven methods, drawing on the experiences of the British National Blood Transfusion Service, to establish a model for developing a voluntary non-remunerated programme. The programme aims to avoid historical pitfalls during its national extension. Historical analysis provided information for introducing voluntary non-remunerated blood donation and planning a nationally-coordinated blood transfusion service.

Model of “secular” cycle of financial capital accumulation

Crises hitting the world economy since the end of the previous century need a deeper explanation than effects of numerous sudden shocks. According to G. Arrighi’s theory, they manifest the final phase of North-American cycle of capital accumulation. Although analytically promising, the theory doesn’t meet broad recognition. A reason could be its weak formalization. This article addresses this problem by developing a mathematical model of capital growth rates. They are measured by nominal yield and interest rates which represent increments of capital in its general, financial form. If capital level follows a logistic path then its growth rate should be described by logistic differential equation. The model is brought to data on government bonds yields in Great Britain in XVIII– XIX centuries and USA — in XX century up to now. The study provides evidence for the pivotal role of financial-capital accumulation in systemic cycles and its S-shaped form. Besides, it reveals importance of trade balance in specifying cycle phases of domestic and global capital expansion.

“All you’ve got to do is stop”: A Qualitative Examination of Gambling Stigma and Discrimination from the Perspective of Lived Experience

People with lived experience have drawn attention to gambling stigma as a harm in itself, justifying discrimination and exacerbating other harms. The gambling establishment’s response has reproduced individual responsibility by reducing stigma to a barrier to help-seeking. More recently, adapting to critiques of individual responsibility, the gambling establishment has expanded the issue to one of services and society. This paper identifies the structural dynamics that drive gambling stigma and discrimination from the perspective of lived experience. Semi-structured interviews were conducted with adults in Great Britain who had experienced gambling harm (n = 40). Several key themes were identified: (1) Harmless fun and individual responsibility; (2) Comparison with substance use; (3) The role of money; (4) Lack of parity in government policy; (5) Stereotypes of “typical” gamblers. The findings show the fundamental driver of stigma is the way commercial gambling functions and is enabled to function by the state, thus perpetuating the very conditions producing stigma in the first place. Stigma-reduction strategies that focus on changing individual behaviour or public information campaigns that tell people to get help early are insufficient: they are just another version of “responsible gambling,” where the individual is expected to do everything. Change requires addressing the unique features of gambling harm, stigma and discrimination, and the position the U.K. government allows commercial gambling to occupy.

Źródła i rola idei uprawnień naturalnych w „Pamflecie bostońskim”

For many centuries, the idea of natural rights has been one of the most important philosophical and legal concepts. Its importance results not only from the importance of the postulates but also, and perhaps above all, because it played a role in the course of changes taking place in modern times. The Boston Pamphlet is one of the first documents issued on the American continent in which revolutionary theses, in particular regarding relations with Great Britain, were formulated in the language of natural rights. The purpose of the article is to analyze the idea of the inalienable rights of the individual, which was expressed in this document. It was indicated that the revolutionary postulates of the authors of the document found as justification and intellectual foundation in a specific vision of inalienable individual rights (and more precisely in the vision proposed by John Locke). The analysis was preceded by a reference to the so-called English liberties, which allowed to place the Pamphlet and the idea of natural rights in a broader context. Attention was also drawn to the fact that although the concept of the inalienable rights of the individual was visible in earlier writings, it was brought to the fore only on the eve of the revolution. The analysis of the concept expressed in the document required the disclosure of those aspects of Locke’s doctrine that played a key role or were even transferred entirely to the content of the document.

Poland in Blue: The Phenomenon of the Denim Clothing Industry in Polish Society During the Socialistic Period

In the People’s Republic of Poland 1 , blue jeans were much more than just an element of clothing. They have become a symbol of freedom, a generational rebellion, and an aspiration for the world on the other side of the Iron Curtain. Aid parcels sent by relatives, mainly from the USA and also from Great Britain, Canada, and Australia played a significant role in getting to know denim clothing in socialist Poland. In the second half of the 1960s, the domestic production of substitute denim-like materials 2 , including denim-like trousers, was started. They were a response to the demand, in particular, of groups of young people for products made of this type of material. The new improvements and material inventions were supervised by the association of clothing industries and research laboratories, which played an essential role in the creation of materials for domestic production (Kortan 1981). A group of active Polish textile and fashion designers contributed to promote comfortable denim clothing from the West. This article presents the role of the denim clothing industry in Poland during the socialist period (1952–1989), considering the cultural context and the impact of this clothing on discovering alternative forms, replacing the originals from capitalist countries. It should be noted that in the People’s Republic of Poland, new types of textile materials were developed and improved so that they corresponded, at least in part, to materials from the West and filled in product gaps. To this end, proprietary commercial versions of fabrics used to produce garments, including the jeans discussed in this publication, were made of a textile known as in Polish word “Teksas” a denim substitute. Researching archival materials and showing achievements in the field of textiles and fashion fills the gap in research on cultural significance of fashion, textile materials and the production of denim and clothing from domestic fabrics of the socialist era.

The evolutionary history of metastatic pancreatic neuroendocrine tumours reveals a therapy driven route to high-grade transformation.

Tumour evolution with acquisition of more aggressive disease characteristics is a hallmark of disseminated cancer. Metastatic pancreatic neuroendocrine tumours (PanNETs) in particular may progress from a low/intermediate to a high-grade disease. The aim of this work was to understand the molecular mechanisms underlying metastatic progression as well as PanNET transformation from a low/intermediate to a high-grade disease. We performed multi-omics analysis (genome/exome sequencing, total RNA-sequencing and methylation array) of 32 longitudinal samples from six patients with metastatic low/intermediate grade PanNET. The clonal composition of tumour lesions and underlying phylogeny of each patient were determined with bioinformatics analyses. Findings were validated in post-alkylating chemotherapy samples from 24 patients with PanNET using targeted next generation sequencing. We validate the current PanNET evolutionary model with MEN1 inactivation that occurs very early in tumourigenesis. This was followed by pronounced genetic diversity on both spatial and temporal levels, with parallel and convergent tumour evolution involving the ATRX/DAXX and mechanistic target of the rapamycin (mTOR) pathways. Following alkylating chemotherapy treatment, some PanNETs developed mismatch repair deficiency and acquired a hypermutational phenotype. This was validated among 16 patients with PanNET who had high-grade progression after alkylating chemotherapy, of whom eight had a tumour mutational burden >50 (50%). In comparison, among the eight patients who did not show high-grade progression, 0 had a tumour mutational burden >50 (0%; odds ratio 'infinite', 95% confidence interval 1.8 to 'infinite', p = 0.02). Our findings contribute to broaden the understanding of metastatic/high-grade PanNETs and suggests that therapy driven disease evolution is an important hallmark of this disease. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

APRIL/BAFF upregulation is associated with clonal B-cell expansion in Hunner-type interstitial cystitis.

Hunner-type interstitial cystitis (HIC) is a chronic inflammatory disease of the urinary bladder with an unknown etiology. We conducted comprehensive immunogenomic profiling of bladder specimens obtained by biopsy and cystectomy from 37 patients with HIC. Next-generation RNA sequencing demonstrated abundant plasma cell infiltration with frequent light chain restriction in HIC-affected bladder tissue. Subsequent analysis of the B-cell receptor repertoire revealed spatial and temporal expansion of B-cell clones. The extent of B-cell clonal expansion was significantly correlated with the gene expression levels of TNFSF13 and TNFSF13B, which encode APRIL and BAFF, respectively. These findings indicate that APRIL and BAFF are the key regulators of clonal B-cell expansion in HIC and might serve as therapeutic targets in this debilitating disease. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

Aristolochic acid-related renal cell carcinoma exhibits a distinct tumor-immune microenvironment favoring response to immune checkpoint blockade.

Immune checkpoint blockade (ICB) is currently the standard of care for metastatic renal cell carcinoma (RCC), but treatment responses remain unpredictable. Aristolochic acid (AA), a prevalent supplement additive in Taiwan, has been associated with RCC and induces signature mutations, although its effect on the tumor-immune microenvironment (TIME) is unclear. We aimed to investigate the immune profile of AA-positive RCCs and explore its potential role as a susceptible candidate for ICB. Tissue samples from 22 patients with clear cell RCC (ccRCC) were collected for whole-exome sequencing to determine the genetic features and AA mutational signature (the discovery cohort). The corresponding RNA was sent for NanoString PanCancer IO 360 gene expression analysis to explore the immunological features. The formalin-fixed, parafilm-embedded slides of ccRCCs were sent for multiplex immunohistochemistry/immunofluorescence stain using Vectra system to evaluate the TIME. Tissues from two patients with metastatic RCC demonstrating complete response to ICB were sent for studies to validate the findings (the index patients). The results showed that AA mutational signatures with high tumor mutational burden (TMB) were present in 31.81% of the tumors in the discovery cohort. Three distinct clusters were observed through NanoString analysis. Clusters 1 and 3 were composed mainly of AA-positive RCCs. Cluster 3 RCCs exhibited higher tumor inflammation signature scores and higher immune cell type scores. Vectra analysis revealed a higher percentage of CD15+ and BATF3+ cells in cluster 1, whereas the percentage of CD8+ cells was potentially higher in cluster 3. Strong AA mutational signatures were found in the tumors of two index patients, and both were grouped to cluster 3. In conclusion, AA may induce higher TMB and alter the immune microenvironment in RCCs, which makes the tumors more susceptible to ICB. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

EMIGRATION OF UKRAINIANS TO THE EU IN THE CONTEST OF GLOBAL GEOPOLITICAL INTERESTS

The article examines the phenomenon of Ukrainian emigration to EU countries, starting from February 2022, caused by military aggression against Ukraine. Forced emigration is considered in the context of the geopolitical interests of the EU, USA, Great Britain and China. The influence of the mass emigration of Ukrainian citizens on the state of European integration of Ukraine is studied, the factors of a positive and negative nature that affect the European integration course of Ukraine are considered.

Nursing poster selection: recent research and review

Jennie Burch reviews three notable poster submissions from the recent Association of Coloproctology of Great Britain and Ireland conference, and details their contributions to gastrointestinal nursing research.

Great Britain and the Romanian territorial concessions in Dobrogea and Transylvania (1940)

This study explores, based on Romanian and British diplomatic sources, some aspects of the international context in which Romania ceded to Hungary part of the historical region of Transylvania, and to Bulgaria - part of the historical region of Dobrogea. The British perspective on the Romanian-German, Romanian-Soviet, Romanian-Hungarian, and Romanian-Bulgarian relations was analyzed in the context of those territorial concessions, as well as the way in which this perspective, in turn, was influenced by the evolution of Romanian-British and Soviet-British relations in the context of British war policy - in general, and in south-eastern Europe - in particular.

Genetic study of an isolated population of adders Vipera berus founded by historic translocation: implications for conservation

Adder Vipera berus populations in Great Britain have undergone substantial declines in recent decades. Isolation due to habitat fragmentation particularly threatens the demographic and genetic health of small populations. Despite the potential benefit of population supplementation in the conservation management of affected populations, there are currently no consensus guidelines for conservation-motivated translocations of this species. Translocations of adders for ecological mitigation of land development are more frequently undertaken, although these are typically poorly documented and insufficiently monitored, representing a wasted opportunity for strategic learning and improvements. We studied an isolated adder population on a protected site in eastern England, founded in 1999 by the translocation of adders from a development site. With known numbers, age and sex of released individuals, this represented an opportunity to improve our understanding of the genetic outcome of a newly created population. Although apparently thriving despite a low founder number, the finding in 2015 of a stillborn clutch of adders raised the possibility of inbreeding in the population. We sampled adders from the translocated population in 2017, and two individuals from the donor site in 2018. Although we found no increase in homozygosity, relatedness and maximum likelihood sibship analysis revealed high levels of consanguinity, especially within the subgroup of adults. Demographic modelling with Approximate Bayesian Computation supported the known origin of the population, but also a subsequent, undocumented adder release to the site, accounting for the observed healthy proportion of young adders with lower levels of consanguinity. Despite the protected habitat site, the population remains isolated, and thus demographically and genetically vulnerable. We highlight the importance of careful post-translocation monitoring including targeted genetic analyses. Strategic data gathering coupled with careful management of translocations, whether for ecological mitigation or conservation rescue, could support significant improvements to the conservation management of this species, including reintroduction initiatives. Keywords: relatedness, inbreeding, stillbirth, foundation bottleneck, population supplementation

A pilot project to explore the mental health and wellbeing among cardiothoracic staff and the impact of virtual reality guided mindfulness

BackgroundThe Cardio-Thoracic (CT) professional group experienced a significant increase in stress and workload during and after the COVID-19 pandemic. The Society for Cardiothoracic Surgery (SCTS) in Great Britain and Ireland with the aim of endorsing positive change. Aim of this project was to understand the Mental Health (MH) and wellbeing status of the CT professionals and to explore Virtual Reality Mindfulness as an intervention to improve MH and wellbeing.MethodsIn February 2022, the SCTS created a Mental Health and Wellbeing Working Group to identify the problem and find solutions. This exploratory project was carried out in two stages. Stage one was an online survey conducted in March 2022 and stage two was a Virtual Reality (VR) mindfulness workshop in March 2023, using the Rescape™ VR mindfulness tool.ResultsStage one: An online QR code survey was sent out to 150 members with 129 (86%) completed responses. 92% expressed that SCTS should create awareness about mental health and wellbeing. 99% said that they should be allowed to speak up and create interventions for members to access, support and relax. Three main themes identified about why CT staff do not discuss their Mental Health problems were fear of lack of awareness (72%), lack of confidentiality (60%) and impact on career (60%). Stage two: 88 members attended the VR session of which 76 (86%) completed the anonymous questionnaire. 97% reported usage was a pleasurable experience, 91% felt more relaxed, 82% felt less stressed, 90% felt calmer and 89% had their mood enhanced.ConclusionOur study findings indicate that CT staff experience considerable effects on their mental health and wellbeing. However, there is a hesitancy to recognise and seek assistance due to concerns about confidentiality and career repercussions. The virtual reality mindfulness session served as a beneficial supplement, with a positive impact in this pilot cohort.

Participation in formal adult education and family life—a gendered story

Abstract Previous literature on adult education (AE) has focused on various aspects of social inequalities, and although many acknowledge the critical role of gender, the mechanisms influencing gender differences in participation are rarely to the fore. Specifically, women report family responsibilities as the main reason for not enrolling in AE. This article examines whether family responsibilities, measured as the age and number of children, act as motivators or barriers to formal AE participation differently among men and women with varying time and monetary resources, that is, partnership status and relative income, in two societies with high formal AE enrolment rates; Finland and Great Britain. The results from Finnish registers and Understanding Society for 1998–2019 demonstrate clearly that family responsibilities related to having young children in the household restrict women from participating in formal AE to a greater extent than men in both countries. Further, while Finnish society enables individuals who traditionally have fewer resources to attend formal AE, that is, single parents and larger families, in Britain, formal AE is mainly taken up by individuals without children or those in stable family situations. The results highlight the importance of institutions in providing equal access to further educational qualifications.

Whistling in the wind?

Abstract Kevin F. Forbes describes how a misleading statistic is imperilling the transition to renewable energy in Great Britain and Ireland

A Feminist Autoethnography of a Family Archive: Affects, Narratives and Practices During Two World Crises: World War II and Covid-19

What happens when we, as researchers, are living through a world crisis such as Covid-19, whilst studying a family epistolary archive produced during World War Two, another world crisis? What epistemological and methodological bridges can be made between the personal experiences of two women (great aunt and great niece) living in two moments of history but who are connected by the process of writing and reading epistolary documents? By conducting a feminist autoethnography of my experience in the Covd-19 pandemic, I reflect upon what it has meant to do feminist historic and archival research of the experience of Trixie Mayer, the first Mexican volunteer to join the Women’s Auxiliary Air Force in Great Britain from 1942 to 1946 and who produced more than 200 personal documents during her war work and afterwards kept them, together with the documents she received form her family in Mexico, for more than 70 years. I analyse how living through a pandemic has helped me understand my great aunt’s crisis experiences from a different perspective, questions, partialities and, at the same time, how these personal and familiar writings have helped me understand and question our current reality and PhD thesis from an alternative perspective.

Gardens reduce seasonal hunger gaps for farmland pollinators.

Gardens can benefit pollinators living in surrounding farmland landscapes, but the reason for their value is not clear. Gardens are no different from many semi-natural farmland habitats in terms of the quantity of floral resources (pollen and nectar) they produce, but the timing of their resource supply is very different, which may explain their value. We show that gardens provide 15% of overall annual nectar in farmland landscapes in Southwest UK, but between 50% and 95% during early spring and late summer when farmland supplies are low. Gardens can therefore reduce seasonal nectar gaps experienced by farmland bumblebees. Consistent with this pattern, bumblebee activity increased in gardens relative to farmland during early spring and late summer. An agent-based model reinforces this point, showing that timing, not quantity, of garden nectar supply enhances bumblebee colony growth and survival in farmland. We show that over 90% of farmland in Great Britain is within 1 km of a garden and therefore positive actions by gardeners could have widespread spillover benefits for pollinators across the country. Given the widespread distribution of gardens around the world, we highlight their important interplay with surrounding landscapes for pollinator ecology and conservation.

Living on an Island: Start-Ups, Spatial Heterogeneity and Remote Entrepreneurial Ecosystems

In this paper we focus specifically on start-ups in remote island entrepreneurial ecosystems (EEs) and consider the differences between these entrepreneurs compared to their mainland Scottish and UK counterparts. We find that Island new start-up entrepreneurs tend to be older, less well educated, more likely to be female, and less likely to be from an ethnic minority. They borrow similar amounts of start-up capital than their mainland counterparts and are equally likely to survive. Despite their geographical remoteness, this suggests that entrepreneurial activity makes a meaningful contribution to their respective EEs.

:The Medieval Welsh “Englynion y Beddau”: The “Stanzas of the Graves,” or “Graves of the Warriors of the Island of Britain,” Attributed to Taliesin

:<i>The Medieval Welsh “Englynion y Beddau”: The “Stanzas of the Graves,” or “Graves of the Warriors of the Island of Britain,” Attributed to Taliesin</i>