ABSTRACT The consumption of Caesalpinia coriaria dry ground fruit (Ccgf) and a Duddingtonia flagrans chlamydospore suspension (DfchS) either individually or in combination for the control of gastrointestinal nematodes (GIN) was assessed in sheep. Forty-five lambs infected with GIN were distributed into five groups (n = 9): Group 1: DfChS at 5 × 105 chlamydospores /kg BW; Group 2: Ccgf at 10% of the total diet; Group 3: Combination of both treatments; Group 4: Levamisole at 6 mg/kg BW; and Group 5: Control. The DfChS was orally administered every third day for 15 days; while the Ccgf, was daily offered during the same period. Faecal egg counts and coprocultures were established. Mean faecal egg accounts (EPG) and infective larvae from coprocultures were recorded. The highest EPG reductions were obtained on the 17th day with the treated group (72.1%); followed by Ccgf group (69.1%) at day 13 and DfchS group (62.6%) also on the 17th day; though, no significant differences were found among treatments. The highest larval reductions were observed with the combined treatment 97.7% (day 17); followed by DfchS group: 96.2% (day 11) and Ccgf group: 70% (day 11). The EPG and larvae reductions achieved with DfchS and Ccgf could be associated to the anthelmintic compounds present in both fungi and plants. The combined use of DfchS and Ccgf against GIN in sheep under grazing conditions seems to be a promising alternative for GIN control in sheep.