Modeling Universal System of Liquid Crystal Displays (MOUSE—LCD) software is demonstrated for the calculation of LC electrooptical behavior and optimization of the new LCD prototypes. In our paper we will demonstrate the effectiveness of the software on various important examples enlisted below. 1. Birefringent color TN and STN-LCDs with a high brightness. 2. Fast LC shutters based on 3π/2 supertwist cells. 3. One-polarizer “guest-host” LCDs with a high contrast and brightness and wide viewing angles. 4. AM-LCDs with low controlling voltages and good gray scale uniformity. 5. Subtractive STN-LCD color system with improved B/W and color contrast. The present version of MOUSE-LCD software includes the new effective method of optical calculations (modified 2×2 Jones matrix approach) and allows for a “back flow” effect in a dynamic response of LC layer.