In order to gain more insight into the nature of the disease and fill in numerous gaps in predictions and treatment, the problem of Alzheimer’s disease (AD) has been extensively studied. A lot of research has already been done to assist identify AD patients utilizing structural and textural features. In this work, texture features based machine learning models are proposed for multi-stage classification of Alzheimer’s disease. Multi-stage classification helps in identifying the disease at early stages and will reduce the suffering of the patients and their family members. The patients in this study are divided into four groups: CN (Cognitive Normal), AD (Alzheimer’s Disease), pMCI (Progressive Mild Cognitive Impairment), and sMCI (Static Mild Cognitive Impairment). The dataset is collected from the ADNI database and has about 15000 MRI raw images in ‘NIFTI’ format. In the first step, the data is preprocessed. Images are converted to the ‘jpg’ format after being stripped of their skulls. 8856 images are selected after preprocessing. For Feature Extraction, FOS (First-Order Statistical) and GLCM (Gray-Level Co-occurrence Matrix) features are utilized. Using normalization, the extracted features are scaled between 0 and 1. The normalized features are then used as input by SVM, Random Forest, Artificial Neural Network, and Decision Tree machine learning methods. Input features used for classification include GLCM, FOS features, and a combination of both. The performance is evaluated using accuracy, recall, F1-score, and precision parameters. The suggested method performs best when both GLCM and FOS features are provided as input. The most accurate method is Random Forest, which has a 66.1% accuracy rate. Decision tree, ANN, and SVM also performed well, with accuracies of 56.4, 58.5, and 59.2 respectively. The proposed approach has the potential for multi-stage classification of Alzheimer’s disease.
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