The present study aims to predict the concentration of uranium (U) in groundwater in India by utilizing water quantity indicators, such as Standardised Precipitation Index (SPI), Standardised Precipitation Evapotranspiration Index (SPEI), and Gravity Recovery and Climate Experiment (GRACE) based groundwater levels. The study adopts a multi-scale approach, ranging from state-level to agroclimatic zones. The findings indicate that the highest levels of U (101–500 μg.L−1), which surpass the World Health Organization (WHO) prescribed limit of 30 μg.L−1 for drinking water, are primarily concentrated in India's plateau and hills regions. The GRACE data map portrays a downward trend in groundwater levels throughout India, with the mid-Gangetic plains experiencing the most significant decline. The meteorological aspect of the study, as indicated by SPI and SPEI, reveals that the plateau and hills region is experiencing a decline in rainfall. The SPEI further underscores the grim picture of decreasing precipitation in northern India. Additionally, the study employs cluster analysis to cluster states according to the division of agro-climatic zones. Lastly, the study employs a random forest algorithm to assess the relative importance of each predictor and predict U concentration under the trinity of precipitation, extraction, and evaporation. The most significant contribution of this work is to identify the hotspots in India that require the most attention in terms of U toxicity owing to groundwater decline. Overall, this study highlights the need for immediate attention to mitigate the adverse impacts of U contamination and aims at sensitizing the stakeholders towards the compelling need to fulfil SDG-3 (health aspects due to U hazard) and SDG-6 (groundwater over-exploitation and deteriorating water quality).
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