The aim of this paper is to determine the extent to which “raised” channel systems may be used as indicators of long-term paleohydrologic change, and hence of broader paleoenvironmental changes, in arid areas during the Cenozoic. The paper reviews the paleohydrologic significance of former drainage systems in arid areas, and demonstrates the application of paleohydrologic methods to the analysis of the long-term evolution of a complex series of exhumed, multistorey, raised channel systems in interior Oman. The paper discusses the range of possible autocyclic and allocyclic controls on changes in channel behaviour through time, as a means of establishing the paleoenvironmental significance of observed changes in paleochannel pattern, morphology, sedimentology and stability. The paper identifies some of the major allocyclic controls, including climatic changes, and particularly the seasonality, magnitude, frequency and distribution of rainfall events during the Cenozoic, together with the degree of continentality and hence the strength and persistence of arid wind systems. Base-level changes, due to eustatic fluctuations and/or tectonic activity, may also act to control long-term patterns of aggradation followed by large-scale landscaping lowering. However, long-term fan ageing associated with progressive aggradation and steepening of paleochannel systems, may also eventually lead to fanhead trenching, independent of any external controls. In addition, progressive expansion of the drainage network and resulting river capture, can lead to marked increases in water and sediment supplies to the fluvial system. The paper also emphasizes the difficulties involved both in differentiating the wide range of possible controls on paleohydrologic response, and also in developing an accurate and precise chronology for desert paleodrainage systems, and in their correlation with non-fluvial sedimentological sequences. The raised channel systems of interior Oman consist of heavily desert varnished chert-and/or ophiolite-rich gravels, dating from some time during the Plio-Pleistocene period. The paleochannels from sinuous gravel ridges rising <30 m above the surounding plains. At least 12 successive generations of superimposed paleochannel systems have been identified, representing major periods of fluvial activity, each of varying duration and character. The earlier generations form typically broad, sinuous, single-thread channels, comprising fine-grained, chert-rich gravels, emented by clear crystalline calcite, and associated with bankfull paleodischarges of up to 1400 m 3 s −1. The later generations become increasingly narrow, steep and less sinuous, with single-thread distributary channels which narrow rapidly downfan. The gravels are coarser grained and dominated by increasing concentrations of ophiolites. The latest stage is associated with fanhead entrenchment, and formation of terrace gravel sheets, poorly cemented by CaCO 3, and dominated by ophiolites. Peak paleoflows may have exceeded 13,000 m 3 s −1. The observed changes have resulted from a complex combination of both internally and externally generated environmental changes during the Cenozoic. Progressive extension of the drainage network on to the ophiolite massif of the mountain source area resulted in river capture and a concomitant increase both in paleodischarges and in supplies of ophiolitic sediments to the paleodrainage system. The early sinuous channels may have developed under a humid to sub-humid climate, in which perennial or seasonal flows allowed the distinct meander paleochannels to form. Ephemeral flows, characterized by flash flood regimes, were probably associated with the later distributary systems, which may reflect semi-arid to arid climatic conditions. The large-scale deflation of the interfluve sediments, which resulted in the eventual exhumation of the cemented, gravel-capped, multistorey paleochannel sequence, is also likely to have occurred during periods of marked continentality, probably during periods of low sea-level associated with the Quaternary glaciations.