Grave Risk Research Articles

Hematogenous Brain Abscess Resulting from Prostatic Abscess Caused by Klebsiella pneumoniae

Brain abscess, a life-threatening infection, can result from hematogenous spread. Although uncommon, Klebsiella pneumoniae can lead to brain abscess and systemic dissemination. In this case report, Klebsiella pneumoniae brain abscess, linked with prostate abscess, in a 57-year-old diabetic male with liver cirrhosis and hepatitis B, resulted in fatal sepsis despite antibiotic therapy. This case underscores Klebsiella's grave risk in immunocompromised patients, highlighting brain abscess and high mortality. Early diagnosis, treatment, and evaluation for multiple organ involvement are crucial.

Arrhythmia burden in patients with congenital heart disease

Abstract Background The prevalence of congenital heart defects (CHD) is rising. Many patients experience arrhythmias either due to the defect itself or necessary intervention. Sudden onset of arrhythmia poses grave risks such as heart failure, stroke, or cardiac death. Research gaps exist regarding high-risk defects, age susceptibility, and prognostic implications of arrhythmia. Purpose Delineate the burden of arrhythmias in patients with CHD. Methods Patients born in the period 1970-2017 and diagnosed with CHD were identified in Swedish nationwide medical registries. Each patient was matched by birthyear and sex with ten controls from the general population. Cox proportional hazard regression model and Fine-Gray regression model with death as competing risk were used to compute risk (hazard ratio [HR]) and cumulative incidence of arrhythmias (supraventricular and ventricular arrhythmias). Estimates were compared with the matched controls. Follow-up started at time of birth. Results We included 63,559 patients and 583,205 matched controls with median follow-up of 12.8 years. Almost two-thirds of the total CHD population were born after year 2000 and 89% (n=56,564) had a simple lesion (defined as atrial or ventricular septal defect, coarctation of the aorta or malformation of the heart valves). During follow-up, 1,632 events of arrhythmia (90% of supraventricular origin) were registered in the population of patients with CHD, yielding an incidence rate of 16.4 per 10,000 person-years (versus 1.6 in the control population). The cumulative incidence of arrhythmias in the total CHD population was slightly increased during childhood compared with the control population, but rose significantly hereafter, illustrated in Figure 1, yielding an overall risk of 10.5 (CI 95%: 9.8-11.2). Stratified by lesion severity, the risk for arrhythmias was 8.7 (CI 95%: 7.6-8.7) and 30.4 (CI 95%: 26.2-35.2) in patients with simple and complex lesions, respectively. Patients with simple CHD lesions displayed a risk of 7.7 (95% CI: 7.1-8.4) for supraventricular arrhythmias and 11.5 (95% CI: 9.2-14.5) for ventricular arrhythmias. Correspondingly, patients with complex CHD lesions displayed risks of 66.7 (95% CI: 42.7-104.2) and 28.9 (95% CI: 24.8-33.6). Conclusion Arrhythmias, irrespective of origin, are common in patients with CHD and correlate with lesion severity. The overall burden of arrhythmias increased significantly after childhood. Meticulous follow-up is vital in order to prevent, detect and treat arrhythmias as it might trigger clinical deterioration and even sudden cardiac death in patients with CHD.

7.C. Scientific session: Commercial determinants of health: impeding attainment of the Sustainable Development Goals

Abstract The commercial determinants of health (CDOH) and the adverse impacts they have on health equity globally, have recently emerged as an innovative growing field of research in public health. The corporate playbook comprises a myriad of strategies and tactics that aim to enhance profitability for the commercial actors, while harming health and posing grave risks to planetary health for current and future generations. The literature however, rarely explicitly makes the connection between commercial determinants and the impact they have on the attainment of the Sustainable Development Goals (SDGs) set out by the United Nations in 2015. This workshop aims to use the commercial determinants of health framework as a new approach to draw attention to, and make linkages between, commercial determinants and the challenges they pose to the attainment of several if not all the global SDGs. The four presentations showcase exemplars of the commercial determinants to include the firearms industry, fossil fuel industry, food industry and the tobacco industry focusing on impacts in low- and middle-income countries (LMICs). The workshop will start with a brief overview of the CDOH framework, their corporate playbook, and the progress in SDG attainment globally while presenting the first case on the firearms industry trade impacting armed conflicts that impede SDG 3 (good health and wellbeing), 10 (reduced inequalities), and 16 (peace, justice and strong institutions). The second presentation will discuss how the fossil fuel industry uses greenwashing tactics to conceal its harmful activities thereby compromising SDGs 7 (affordable and clean energy), 11 (sustainable cities and communities), and 13 (climate action). The third presentation will address how the tobacco industry impedes the advancement of SDG 3, 8 (decent work and economic growth), 13 (climate action) and 17 (partnerships for the goals) perpetuated by national system level attributes. The last presentation will showcase how the food industry challenges SDG 3 in its production of ultra-processed foods. The workshop will draw on evidence from LMICs, but is also eye opening for high-income countries of Europe which face industry interference in social and health policymaking progress in SGD attainment. The audience will be engaged in a short warm-up exercise at the start of the workshop through an app for real-time feedback accessed through a QR code on the screen, and will interact with the presenters at the end of the workshop if time permits. Key messages • All commercial actors pose a direct or indirect threat to progress in attaining the SDGs. • The commercial determinants of health pose are in direct contradiction to the SDG 17 through their corporate playbook.

Workplace violence against healthcare workers in Türkiye: Experiences, opinions, and suggestions

Workplace violence against healthcare workers is a complex issue with significant implications for the safety and wellbeing of professionals in the healthcare sector. Drawing on data from 136 participants across Türkiye, this study explores the prevalence, forms, impacts, and management strategies of workplace violence in healthcare settings. The demographic characteristics of the participants reveal a diverse composition of healthcare workers affected by workplace violence, highlighting the universal nature of the issue. Verbal abuse emerges as a predominant form of violence, ranging from insults and threats to humiliation, while instances of physical violence pose grave risks to healthcare professionals. The study also underscores the inadequacy of support systems within healthcare institutions and the legal system, exacerbating the distress experienced by healthcare workers. Strategies for managing workplace violence include internal coping mechanisms, peer support, and institutional intervention, underscoring the need for comprehensive training programs and enhanced institutional protocols. Recommendations for prevention encompass a multifaceted approach involving enhanced security measures, support systems, and policy reforms at various levels. The study concludes with a call to action for concerted efforts to address workplace violence against healthcare workers, emphasizing the importance of targeted interventions to ensure the safety and well-being of professionals in their workplace. These findings provide valuable insights into the complexities of workplace violence in healthcare settings and highlight the urgent need for action to address this pressing issue.

Study on nonlinear coupled dynamic response of the integrated polar ocean nuclear energy platform

An integrated polar ocean nuclear energy platform is capable of providing adequate electrical and thermal energy essential for polar oceanic development activities. Precisely forecasting the platform's motion response within the marine environment is pivotal for the assurance of its safety. A scenario where the natural frequencies of heave, roll, and pitch of such an integrated polar ocean nuclear energy platform align closely to a 2:1:1 ratio, and when the wave frequency nearly matches the aggregate of the platform's natural heave and pitch frequencies, could induce a phenomenon known as sum-type nonlinear internal resonance. This phenomenon can significantly amplify the swing (roll or pitch) motion of the platform, posing a grave risk to both personnel and equipment onboard. Investigating these nonlinear internal resonance phenomena within the nuclear energy platform is critical for informing both the design and practical deployment of these platforms. Following the validation of the numerical simulation against experimental results, a detailed analysis of sum-type nonlinear internal resonance phenomena in the integrated polar ocean nuclear energy platform under regular wave conditions was performed using a combination of numerical simulations and nonlinear dynamics theory. It was observed that upon exceeding a certain wave height threshold, the platform enters a state of sum-type nonlinear internal resonance, engendering highly complex motion patterns. Notably, irrespective of initial conditions, this resonance triggers the roll motion of the platform, facilitating the external dissipation of energy in a half-sub-harmonic vibration manner. Increasing damping can effectively suppress the occurrence of nonlinear internal resonance phenomena in the platform. In designing the integrated polar ocean nuclear energy platform, it's crucial to avoid having the natural frequency ratios of heave, pitch, and roll align as 2:1:1. If unavoidable, adding side plates to increase damping can mitigate the effects of sum-type nonlinear internal resonance.

Effectiveness and mechanism of microbial dust suppressant on coal dust with different metamorphosis degree.

The extraction of coal from open-pit mines significantly contributes to environmental degradation, posing grave risks to human health and the operational stability of machinery. In this milieu, microbial dust suppressants leveraging microbially induced carbonate precipitation (MICP) demonstrate substantial potential for application. This manuscript undertakes an exploration of the dust mitigation efficiency, consolidation attributes, and the fundamental mechanisms of microbial dust suppressants across coal dust samples with varying metamorphic gradations. Empirical observations indicate that, in resistance tests against wind and rain, lignite coal underwent mass losses of 7.43g·m-2·min-1 and 98.62g·m-2·min-1, respectively. The production of consolidating agents within the lignite dust, attributable to the microbial suppressants, was measured at 0.15g per unit mass, a value of 1.25 and 1.07 times greater than that observed in bituminous coal and anthracite, respectively. Scanning electron microscopy coupled with X-ray energy-dispersive spectroscopy (SEM-EDS) and X-ray diffraction (XRD) analyses illuminated that the consolidating products within the coal dust predominantly constituted calcite and vaterite forms of calcium carbonate. The consolidation mechanism of coal dust via microbial suppressants is articulated as follows: Subsequent to the application on coal dust, the suppressants induce the formation of carbonate precipitates with inherent adhesive properties. These carbonates affix to the surfaces of coal dust particles, progressively encapsulating them. Furthermore, they play a pivotal role in bridging and filling the interstices between adjacent dust particles, thereby culminating in the genesis of a dense, cohesive mass capable of withstanding erosive forces.

Quantifying Vulnerability

Humanitarianism has recently undergone a so-called innovation turn, utilizing cutting-edge technologies to enhance the reach and efficiency of humanitarian aid. This article focuses on novel advances in the way aid organizations record, measure, and classify household vulnerability among Syrian refugees. Drawing on ethnographic fieldwork in Lebanon and Jordan, I explore how the datafication of refugees in humanitarian action not only reveals the constitutive limits of quantitative ontologies but also poses transformative implications for the institutional configurations of humanitarianism. In particular, I suggest that the aid sector’s growing reliance on data systems entrenches an extractive relationship between humanitarian organizations and refugees that conscripts, entangles, and unsettles data practitioners themselves. I conclude by pointing to vulnerability assessments as one node within a larger apparatus of integrated data systems, one that centralizes power within the humanitarian industry and poses grave risks for refugee rights.

Use of bidirectional Mendelian randomization to unveil the association of Helicobacter pylori infection and autoimmune thyroid diseases.

Previous observational studies found associations between Helicobacter pylori infection and autoimmune thyroid diseases (AITDs), but the causal nature of this association is still uncertain. We investigated the causal effect of six crucial antibodies against H. pylori on AITDs using a bidirectional Mendelian randomization (MR). We found that anti-H. pylori outer membrane protein (OMP) significantly increased the risk of hyperthyroidism and Graves' disease (GD). In addition, our reverse MR analysis indicated that hyperthyroidism could increase the levels of cytotoxin-associated gene A and OMP antibodies. We also observed causal roles of GD on anti-H. pylori OMP. Our analyses indicate the mutual effects of H. pylori infection and AITDs, suggesting the existence of a gut-thyroid axis. These results also provide evidence of the bidirectional causal association between anti-H. pylori OMP with hyperthyroidism and GD, resulting in a vicious circle.

Electrochemical impedimetric enzyme-less detection of non-electroactive organophosphate pesticides using zirconium metal organic framework

Residues of pesticides found in fruits and vegetables pose a grave risk to organisms, potentially causing acute and chronic diseases when their levels surpass the maximum residual limits (MRLs) for human consumption. This study targeted to detect non-electroactive organophosphate pesticides (OPPs), including malathion, dimethoate, chlorpyrifos, monocrotophos, and glyphosate using a zirconium-terephthalic acid combined metal organic framework (Zr-BDC) byelectrochemical impedance spectroscopy (EIS). Comprehensive analysis of the synthesized Zr-BDC showed an extensive specific surface area of 868 m2g−1. Nyquist plots and equivalent circuit models confirmed the higher adsorption of OPPs with P = S and P-S (malathion, dimethoate, chlorpyrifos) onto glassy carbon modified by Zr-BDC (Zr-BDC/GCE), in contrast to OPPs with P = O (monocrotophos, glyphosate, and non-OPPs). The Zr-BDC/GCE displayed a linear detection range of 5.0 nM to 70.0 μM, with limit of detections (LODs) of 3.6, 4.1, 4.5, 3.8, and 4.3 nM for malathion, dimethoate, chlorpyrifos, monocrotophos, and glyphosate respectively. The sensor exhibited notable recovery 91.0 – 98.6 % and RSDs 1.19 – 1.97 % (n = 3) when tested with real samples (apple and cabbage) and demonstrating substantial reproducibility and long-term stability.

Effect of Genotype on Cadmium and Trace Element Accumulation in Wheat from Weakly Alkaline Cadmium-contaminated Soil.

Cadmium (Cd) contamination of farmland soils leads to Cd accumulation in crops and reduced micronutrient uptake, posing grave risks to food safety. Herein, we investigated the enrichment and transportation patterns of Cd and trace elements in different parts of six wheat genotypes grown in weakly alkaline Cd-contaminated soils via pot experiments. The results revealed that the wheat grain variety with high Cd accumulation (Ningmai13) demonstrated a 1.94-fold increase compared to the variety with low accumulation (Yanong0428). The transfer factor of Cd from wheat straw to grain ranged from 0.319 to 0.761, while the transfer factor of Cd from root to straw ranged from 0.167 to 0.461. Furthermore, the concentrations of other metals in wheat grains followed the order of Zn > Mn > Fe > Cu. There was a significant positive correlation between Cd and Mn in grains, indicating a potential synergistic effect. Overall, this study provides valuable insights into the regulation of micronutrient intake to modulate Cd uptake in wheat.

Okeanomitos corallinicola gen. and sp. nov. (Nostocales, Cyanobacteria), a new toxic marine heterocyte-forming Cyanobacterium from a coral reef.

Cyanobacterial mats supplanting coral and spreading coral diseases in tropical reefs, intensified by environmental shifts caused by human-induced pressures, nutrient enrichment, and global climate change, pose grave risks to the survival of coral ecosystems. In this study, we characterized Okeanomitos corallinicola gen. and sp. nov., a newly discovered toxic marine heterocyte-forming cyanobacterium isolated from a coral reef ecosystem of the South China Sea. Phylogenetic analysis, based on the 16S rRNA gene and the secondary structure of the 16S-23S rRNA intergenic region, placed this species in a clade distinct from closely related genera, that is, Sphaerospermopsis stricto sensu, Raphidiopsis, and Amphiheterocytum. The O. corallinicola is a marine benthic species lacking gas vesicles, distinguishing it from other members of the Aphanizomenonaceae family. The genome of O. corallinicola is large and exhibits diverse functional capabilities, potentially contributing to the resilience and adaptability of coral reef ecosystems. Invitro assays revealed that O. corallinicola demonstrates notable cytotoxic activity against various cancer cell lines, suggesting its potential as a source of novel anticancer compounds. Furthermore, the identification of residual saxitoxin biosynthesis function in the genome of O. corallinicola, a marine cyanobacteria, supports the theory that saxitoxin genes in cyanobacteria and dinoflagellates may have been horizontally transferred between them or may have originated from a shared ancestor. Overall, the identification and characterization of O. corallinicola provides valuable contributions to cyanobacterial taxonomy, offering novel perspectives on complex interactions within coral reef ecosystems.

Puerarin-containing rhein-crosslinked tyramine-modified hyaluronic acid hydrogel for antibacterial and anti-inflammatory wound dressings

Wound infections, posing a grave risk of severe physical consequences and even mortality, exact a substantial financial toll on society, rendering them among the most formidable challenges confronting our world today. A critical imperative is the development of hydrogel dressings endowed with immune-regulating and antibacterial properties. This study is founded upon the symbiotic physical and efficacious attributes of two small natural molecules. An injectable hydrogel is meticulously crafted by encapsulating puerarin (PUE) into tyramine-modified hyaluronic acid, subsequently introducing rhein (RHE), and catalyzing the formation of inter-phenol crosslinks with H2O2/horseradish peroxidase (HA-Tyr-R@P). Exhibiting a favorable microenvironmental impact the developed hydrogel attains an antibacterial efficacy exceeding 95 %, coupled with a wound closure rate twice that of the control group. HA-Tyr-R@P hydrogels not only inhibit bacterial growth but also mitigate inflammation, fostering wound healing, owing to their harmonized physicochemical characteristics and synergistic therapeutic effects. This work underscores the creation of a singular, versatile hydrogel platform, negating the complexities and side effects associated with pharmaceutical preparations. Furthermore, it offers new ideas for the formulation of RHE-based hydrogels for wound healing, emphasizing the pivotal role of natural small molecules in advancing biological materials.

Sacred Places in a Burning World

ABSTRACT Sacred places today are at grave risk from climate change as the waters rise around these sites and fires approach and engulf them. Even the briefest online search results in a long list of examples. Summers of record heat in northern Spain imperil pilgrims to Santiago de Compostela. Rising sea levels in the Florida Panhandle threaten hundreds of ancient Indigenous sacred sites. Flooding across East Asia has displaced Buddhist monks from their monasteries. Extreme heat in Mecca led to stampedes in 1990 and again in 2015, killing hundreds of pilgrims. In 2017, Hurricane Harvey inundated the sanctuary of the oldest synagogue in Houston, Texas, Congregation Beth Israel. Shrines and other sacred spaces caught in the path of extreme climate events and their aftermaths constitute a distinctive field of lived religious experience and practice in the post-Anthropocene, another name for our cataclysmic post-secular globalized world.

Actinomycetes as a Possible Source of Bioremediation of Heavy Metal Cadmium from Contaminated Soil

Annually, a significant volume of chemicals, encompassing fertilizers and pesticides, is administered to agricultural soils. Using pesticides and fertilizers, agricultural practices contribute to heavy metal Cadmium (Cd), Copper (Cu), Lead (Pb) and Zinc (Zn) pollution. Heavy metals and pesticides are high at the peak of ecological contaminants, presence of this has introduced grave risks to the health of the population and agronomics. Among heavy metals, cadmium (Cd) is recognized for its high mobility in various environmental settings. Cd has a deleterious effect on plant phenotypic, cytotoxicity (e.g., lowering chlorophyll concentration and limiting photosynthetic effectiveness), and metabolic activities (e.g., chlorosis and necrosis). Microbial bioremediation by using microorganisms is one of the secure, pure, cost operative and eco-friendly technology for decontaminating polluting sites as compared to physical and chemical techniques. Among microbes, Actinobacteria hold a paramount position, serving as key players in numerous biological processes, utilize toxins as carbon source and turn into high concentrations of pesticides, chemical complexes and heavy metals into commercially viable antibiotics, enzymes, proteins, and plant growth promoting hormones. This study is an effort to explore the potent cadmium resistance actinomycetes to reduce cadmium levels to enhance degradation. For this purpose, 53 actinomycetes strains were tested for heavy metal resistance and tolerance to Cadmium against different concentrations. After secondary screening Four potent isolate have the potential to grow at 1000 mg/L concentration of Cadmium in the medium. When they are able to grow on heavy metal containing media it could be beneficial for reduction and elimination of toxic metals from contaminated environment. When it comes to achieving a suitable level of metal tolerance, this potent powerful actinomycetes strain Streptomyces pactum have been identified to be promising.

Chronic dacryocystitis: An insight into bacteriology and antimicrobial sensitivity pattern.

Adequate management of chronic dacryocystitis is an essential prerequisite before any intraocular surgery owing to a grave risk of endophthalmitis. The knowledge of bacteriology of chronic dacryocystitis would accentuate the choice of effective antimicrobial agents and thus help in reducing the irrational use of antimicrobial agents and subsequent development of drug resistance. We aimed to identify the causative bacterial flora and study the antimicrobial sensitivity and resistance pattern in cases of chronic dacryocystitis. This was a cross-sectional observational study. Conjunctival swabs were obtained from both eyes from 102 patients with clinical evidence of chronic dacryocystitis. Specimens for microbiological analysis were obtained, either from the conjunctival cul-de-sac and everted puncta by applying pressure over the lacrimal sac area or from the refluxing material after irrigating the lacrimal sac with sterile saline. The specimens were sent for culture and sensitivity in the department of microbiology. Ethical approvals were duly obtained. Percentage assessment was used for statistical analysis. The cultures showed the presence of Staphylococcus aureus in 50% of bacterial isolates obtained from the involved eyes, followed by coagulase-negative Staphylococcus in 11.53% of isolates and Enterococcus also in 11.53% of isolates. It was observed that cefoxitin was the most sensitive antibiotic against Gram-positive organisms, followed by vancomycin and clindamycin, whereas maximum resistance was seen for penicillin and ofloxacin. For Gram-negative organisms, imipenem was found to be most sensitive, followed by gentamicin and co-amoxiclav, whereas maximum resistance was seen for ciprofloxacin. It was concluded that Gram-positive bacteria predominantly S. aureus was the most commonly isolated bacteria in cases of chronic dacryocystitis as compared to Gram-negative bacteria and cefoxitin was found to be the overall most effective antibiotic for Gram-positive bacteria.

From resource curse to green growth: Exploring the role of energy utilization and natural resource abundance in economic development

AbstractThis study delves into the profound repercussions of the resource curse hypothesis within the Brazil, Russia, India, China, and South Africa (BRICS) nations from 1991 to 2022, examining the intricate interplay among natural resource abundance, energy consumption, and economic development (ED). Methodologically, it employs the cross‐sectionally augmented Dickey–Fuller test to assess stationarity and utilizes the Westerlund cointegration technique to analyze cointegration. Subsequently, the cross‐sectionally augmented autoregressive distributive lag model is deployed to explore the impact of natural resource availability, renewable and non‐renewable energy utilization, and carbon emissions on ED within these countries. The findings reveal a stark reality wherein both carbon emissions and non‐renewable energy consumption wield a consistently positive influence on short‐ and long‐term economic growth across the BRICS economies. Particularly striking is the dominant impact of non‐renewable energy consumption. However, this comes in stark contrast to the adverse effects identified with excessive resource and coal rents, signifying potential economic setbacks arising from rampant natural resource exploitation. Furthermore, the suboptimal utilization of renewable energy resources hints at a detrimental effect on ED. These results transcend the confines of developing nations, underscoring the universality of the resource curse hypothesis, affecting both developing and developed countries. The study illuminates the grave risks inherent in overreliance and overexploitation of natural resources, elucidating heightened competition that severely impedes the ED trajectory of the BRICS countries in both short and long terms. Policymakers must prioritize economic diversification, implement sustainable resource management, and invest in innovative technologies to mitigate the resource curse in BRICS nations, fostering resilience and sustainable economic growth. In conclusion, This study highlights the severe impact of the resource curse in BRICS nations, stressing the imperative for adept resource management to counter the risks linked with overdependence on non‐renewable resources and bolster sustainable economic growth.

Global Concerns on Human Rights: A Comprehensive Overview

There are several issues that have a profound global impact and have significantly influenced the protection of human rights. Human rights, intrinsic to all individuals, serve as the cornerstone of dignity and fairness across the globe. Despite the existence of country specific legal framework for human rights protection, the issue persists on global scale. The major issue faced among the pressing human rights concerns is the plight of children, whose rights are often infringed upon through exploitation or lack of adequate care, manifesting in issues like adoption complexities. Moreover, the escalating influence wielded by both developed and developing nations has intensified the threat of nuclear proliferation, posing a grave risk to global security. Henceforth this paper aims to elaborate on the mentioned issues as well as other aspects of human rights violation that is faced by people in contemporary times. In addition to the foundational principles of human rights, this paper seeks to delve into various dimensions encompassing social, economic, political, and environmental factors. It aims to illuminate the multifaceted nature of human rights and shed light on the prevalent exploitation and abuse faced by victims around the world. Moreover, the paper endeavors to propose feasible solutions aimed at addressing the multifaceted challenges associated with human rights violations.

Managing Cyber Security Debt: Strategies for Identification, Prioritisation, and Mitigation

This paper explores cyber security debt, a technical debt arising from unaddressed security vulnerabilities in an organisation's IT systems. These vulnerabilities accumulate due to resource limitations, time constraints, and expertise gaps, potentially leading to security breaches and data compromises. The paper outlines the cyber security debt management process involving identification, prioritisation, and mitigation strategies. Drawing parallels to financial debt, the authors emphasise the escalating risks of delaying cyber security debt repayment. The paper underscores the significance of diligent debt management in maintaining digital resilience and mitigating cyber threats. The increasing interconnectedness of systems and rapid software development has given rise to a hidden challenge known as cyber security debt. Cyber security debt is posed as a subset of technical debt, encompassing the accumulation of security vulnerabilities within an organisation's IT infrastructure and applications. Drawing a parallel between cyber security debt and its financial counterpart, the authors underscore the grave risks of deferring debt repayment. Just as financial debt accrues interest, unresolved security vulnerabilities compound over time, elevating the likelihood of breaches and data exposure. A poignant case study of the Equifax breach exemplifies the real-world consequences of neglecting security debt management. The failure to patch a well-known vulnerability led to a colossal data breach, highlighting the urgency of addressing security weaknesses promptly. Complex in nature, cyber security debt materialises when organisations fail to address vulnerabilities during various operational life cycles. These vulnerabilities might remain concealed within IT architecture, legacy code, or third-party libraries, posing a formidable challenge to detection and resolution. By understanding the parallels between financial and cyber security debt and proactively managing the latter, organisations can enhance their ability to safeguard against evolving cyber threats and maintain a robust security posture.

Sipping a sustainable life: Exploring drivers and barriers in consumer attitudes toward non or low alcoholic spirits

Alcohol consumption continues to be prevalent and is on the rise in many countries, posing a grave risk for the health and wellbeing of millions and creating a strain on health services worldwide. A hopeful trend has emerged, however, as consumers' growing preference for healthier, sustainable lifestyles has led traditional alcoholic brands to innovate, launching reduced or non-alcoholic (NoLo) options. This aligns with the SDGs and is reflected in NoLo spirits representing four of Spain's top ten disruptive innovations of 2022. This paper uses a mixed methodology in a qualitative-quantitative sequential approach to gain insight into this phenomenon. The study involved 13 in-depth interviews with HoReCa (an acronym for Hotels, Restaurants, and Caterings) professionals and four focus groups among consumers. Second, behavioral reasoning theory (BRT) was used in a quantitative study aiming to explore motivations for and against consuming NoLo spirits. Data from a survey of 620 participants was conducted and analyzed using SEM-PLS to measure the antecedents of consumer's behavioral intention towards NoLo spirits and to gauge the potential for marketing opportunities. The research reveals that the purchase intention of NoLo spirits is strongly related to health consciousness, while enjoying the effects of alcohol for fun and entertainment, and the social pressure to drink hinders its consumption. In addition, it was found that “reasons for” are more substantial than “reasons against” the consumption of those beverages, differing significantly by age group. Results offer implications for theory and practice, including recommendations for practitioners and regulators willing to improve sustainability in the industry. Further, this paper helps augment the innovation adoption literature by using BRT in the paradoxical context of consumers' increasing alcohol abuse despite their professed attempts to adopt healthier lifestyles.

Bacteroidaceae, Bacteroides, and Veillonella: emerging protectors against Graves' disease.

Graves' disease (GD) is the most common cause of hyperthyroidism, and its pathogenesis remains incompletely elucidated. Numerous studies have implicated the gut microbiota in the development of thyroid disorders. This study employs Mendelian randomization analysis to investigate the characteristics of gut microbiota in GD patients, aiming to offer novel insights into the etiology and treatment of Graves' disease. Two-sample Mendelian randomization (MR) analysis was employed to assess the causal relationship between Graves' disease and the gut microbiota composition. Gut microbiota data were sourced from the international consortium MiBioGen, while Graves' disease data were obtained from FINNGEN. Eligible single nucleotide polymorphisms (SNPs) were selected as instrumental variables. Multiple analysis methods, including inverse variance-weighted (IVW), MR-Egger regression, weighted median, weighted mode, and MR-RAPS, were utilized. Sensitivity analyses were conducted employing MR-Egger intercept test, Cochran's Q test, and leave-one-out analysis as quality control measures. The Mendelian randomization study conducted in a European population revealed a decreased risk of Graves' disease associated with Bacteroidaceae (Odds ratio (OR) [95% confidence interval (CI)]: 0.89 [0.89 ~ 0.90], adjusted P value: <0.001), Bacteroides (OR: [95% CI]: 0.555 [0.437 ~ 0.706], adjusted P value: <0.001), and Veillonella (OR [95% CI]: 0.632 [0.492 ~ 0.811], adjusted P value: 0.016). No significant evidence of heterogeneity, or horizontal pleiotropy was detected. Furthermore, the preliminary MR analysis identified 13 bacterial species including Eubacterium brachy group and Family XIII AD3011 group, exhibiting significant associations with Graves' disease onset, suggesting potential causal effects. A causal relationship exists between gut microbiota and Graves' disease. Bacteroidaceae, Bacteroides, and Veillonella emerge as protective factors against Graves' disease development. Prospective probiotic supplementation may offer a novel avenue for adjunctive treatment in the management of Graves' disease in the future.