Surveys for virus and virus‐like diseases were carried out in commercial vineyards of the main grapevine‐growing areas of Egypt along the river Nile and in recently reclaimed desert lands. The only symptoms observed and identified with reasonable confidence in the field were those of leafroll disease in red‐berried cultivars. No virus was transmitted to herbaceous hosts by mechanical inoculation from glasshouse‐forced cuttings of about 300 vines (40% of total samples). By contrast, ELISA tests showed that 78% of the assayed European vines (521 out of 664) were infected by one (29%) or more (49%) viruses. Grapevine virus A (GVA) was the most widespread virus (67.9% infection), followed by Grapevine leafroll‐associated virus 3 (GLRaV‐3) (55.9% infection). All the other viruses tested for were scarcely represented, i.e. Grapevine leafroll‐associated virus 1 (GLRaV‐1) 1.8% infection, Grapevine leafroll‐associated virus 2 (GLRaV‐2) 1.4% infection, Grapevine virus B (GVB) (0.6% infection) and Grapevine fleck virus (GFkV) (0.2% infection), or, like Grapevine fanleaf virus (GFLV), were totally absent. The infection rate of native cultivars (86%) was particularly heavy. ‘Banaty Abiad’ and ‘Romy Ahmer’, the two major Egyptian cultivars, had infection levels of 78% and 89%, respectively, and ‘Fayoumy’, the most important cultivar in the Fayoum area, had 96% infection. Totally infected were the tested samples of several minor native cultivars such as ‘Farg El‐Tair’, ‘Siwi Abiad’, ‘Ta’afi’, ‘Romy Abiad’, ‘Eswid El‐Wady’, ‘Edkawy’ and ‘Bez El‐Anza’. Slightly better was the sanitary situation of imported European grapevine cultivars (60% infection) and of American rootstocks (11.5% infection). In rootstocks, infection rate by GVA and GLRaV‐3 was 5.5%, whereas GVB and GLRaV‐1 were only sporadically detected.