ABSTRACT The article provides additional information that emphasizes the growing international interest in the impact of climate (temperature, humidity, precipitation, solar activity) on grape yields and the quality of terroir wine. The study deals with the climate gradient of the terroir of the Derbent region of the Republic of Dagestan (Russia), located on the terraced accumulative-coastal plain of the Caspian lowland, stretching for 160 km from north to south in a narrow strip between the coast of the Caspian Sea and the foothills. The influence of soil and climatic conditions on the biochemical characteristics of red dry wines ‘Kara-Koysu’ from Cabernet Sauvignon wingrapes of the 2019–2021 harvest was studied. The growing season occurred in dry, moderately humid conditions in 2019; hot, with a lot of precipitation in 2020 and more extreme conditions in 2021. The conditions of recent years have contributed to the change of almost all the studied indicators of tested wines. Studies have found that the climatic conditions of 2020–2021 were more favorable for obtaining a rich harvest, high-quality wines due to more UV light exposure and precipitation.