Granular Cell Odontogenic Tumor Research Articles

Central Granular Cell Odontogenic Tumor: Case Report with Literature Review of Cases Reported in the Last 71 years.

The central granular cell odontogenic tumor (CGCOT) is a rare, benign, slowly growing, odontogenic neoplasm. CGCOT was not considered as a distinct entity in the WHO classification reported on 2017. This study reports a rare case of CGCOT involving the right side of maxillary anterior region of a 39-year-old white woman. In addition, to better delineate the clinical, radiographic, histopathologic and immunohistochemical characteristics of CGCOT, a literature review of all published cases (in PubMed/ Google Scholar/ MEDLINE/Scopus) of CGCOT is provided. CGCOT is a very uncommon tumor, with only 51 reported cases in the literature. The present case is interesting regarding to its rarity for being in the maxillary anterior region, which has not been previously reported in Asia. The immunohistochemical findings of the current case and other cases in the literature review, verified the mesenchymal origin of granular cells and odontogenic nature of the epithelium islands, which can be a possible promise for placing this lesion in the future WHO odontogenic tumor classification.

Granular cell ameloblastoma: A rare and unique variant

Ameloblastoma is a slow-growing and locally invasive epithelial odontogenic tumor of the jaw that runs a benign course in most cases. Granular cell ameloblastoma is a rare subtype of ameloblastoma, showing the granular transformation of its cytoplasm. It is considered as an aggressive variant of ameloblastoma. Herein, we report the case of a 34-year-old male patient who presented with a swelling in the left cheek for a 1-year duration with a recent rapid increase in size. Examination showed a 4 × 3 cm growth involving the left buccal mucosa and retromolar area. Imaging studies showed expansile lytic lesion mandible. Biopsy revealed neoplasm with odontogenic epithelial islands showing peripheral palisading of tall columnar cells with reversal of polarity and the center of the islands showing stellate reticulum-like cells which were markedly replaced by granular cells. Granular cells can appear in various odontogenic and non- odontogenic tumors. When there is extensive granular cell change in ameloblastoma, it should be differentiated from other oral lesions with granular cells including granular cell odontogenic tumor, granular cell tumor, and congenital epulis.Herein we report the case of a 34-year-old male patient presented with swelling left cheek of one-year duration with recent rapid increase in size. Examination showed a 4x3 cm growth involving left buccal mucosa and retromolar area. Imaging studies showed expansile lytic lesion mandible. Biopsy revealed neoplasm with odontogenic epithelial islands showing peripheral palisading of tall columnar cells with reversal of polarity and the center of the islands showing stellate reticulum like cells which were markedly replaced by granular cells. Granular cells can appear in various odontogenic and nonodontogenic tumors. When there is extensive granular cell change in ameloblastoma it should be differentiated from other oral lesions with granular cells including granular cell odontogenic tumour, granular cell tumour and congenital epulis.

Granular cell odontogenic tumor: report of a rare case and a review of literature

BackgroundGranular cell odontogenic tumor (GCOT) is a rare neoplasm with about 45 cases reported in the literature. It usually occurs in the posterior mandible of middle-aged women.Case presentationWe report a case of asymptomatic GCOT in the posterior mandible of a 28 years old female and provide a literature review of GCOT cases. Some unusual features such as root resorption, displacement of inferior tooth canal, and multilocular appearance were considerable in this case.ConclusionsComplete surgical excision of the lesion was beneficial for the patient.

Ameloblastoma with granular cell pattern - A bizarre presentation

Ameloblastoma with granular cell pattern - A bizarre presentation - JOOO- Print ISSN No: - 2395-6186 Online ISSN No:- 2395-6194 Article DOI No:- 10.18231/j.jooo.2019.025, Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology-J Oral Med Oral Surg Oral Pathol Oral Radiol

An early central granular cell odontogenic tumor arising from the dental follicle of an impacted mandibular third molar

Central granular cell odontogenic tumor (CGCOT) is a rare odontogenic tumor that occurs more frequently as a unilocular radiolucent lesion in the premolar-molar region of the mandible in middle-aged women. This case report presented an early CGCOT arising from the dental follicle of an impacted mandibular third molar of a young man. This 19-year-old male patient was referred from his family dentist to our outpatient clinic for extraction of an impacted left mandibular third molar with an enlarged dental follicle (Fig. 1A). The impacted tooth did not cause any signs and symptoms and was found by a routine dental radiographic examination. The patient was scheduled for tooth extraction under local anesthesia. After buccal gingival flap elevation, the impacted third molar was

Central granular cell odontogenic tumor of the mandible

Central granular cell odontogenic tumor of the mandible

Central granular cell odontogenic tumor: a systematic review

Central granular cell odontogenic tumor (CGCOT) is a rare benign odontogenic neoplasm reported with various terms and is not included in the 2005 WHO classification of odontogenic tumors. It shows a predilection for middle-aged women, usually presenting as an asymptomatic swelling of the mandibular premolar-molar region. Radiographic manifestations include unilocular or multilocular radiolucent lesion, but mixed density lesions can also occur. Histopathology shows sheets and lobules of round to polygonal cells with abundant eosinophilic, granular cytoplasm and eccentrically placed nuclei. Immunohistochemical and ultrastructural features suggest the histiocytic origin of granular cells. The neoplasm does not exhibit an aggressive biological behavior and hence enucleation or curettage ensuring complete removal remains the treatment of choice. We present a systematic review on clinical, radiological, histopathological, immunohistochemical and treatment aspect of CGCOT. Published articles were identified through a literature search using online databases (PubMed, MEDLINE, Scopus) and cross-references for papers published from the year 1950 to March 2013. From a total of 37 papers, 26 (38 cases) were extracted from the database for systematic review.

Central granular cell odontogenic tumor: The first reported case in Oriental people and literature review

The central granular cell odontogenic tumor (CGCOT) is a rare odontogenic neoplasm, usually occurring in the mandible of middle-aged women. Previous studies have reported only 34 cases, all of whom were white or black individuals. The present study reports an additional case of CGCOT, occurring in the posterior mandible of a 69-year-old Taiwanese man. To the authors' knowledge, this is the first reported case in Oriental people. The odontogenic epithelium exhibited strong positive immunoreactivity for pan-cytokeratin, and focal weak staining for bcl-2. The granular cells showed strong positivity for vimentin and α1-antichymotrypsin, and focal weak staining for carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), and CD68. These features indicated a mesenchymal origin and possible histiocytic lineage for the granular cells. This study also presents a literature review and describes immunohistochemical features of the tumor.

Central granular cell odontogenic tumor of mandible: A case report

Central granular cell odontogenic tumor (CGCOT) is a rare benign odontogenic neoplasm reported with various terms. We present a case of CGCOT involving the right side of mandible crossing the midline of a 25 year old female. The orthopantomogram showed a well-demarcated multilocular radiolucent lesion extending from distal of right mandibular second molar to the mesial of left mandibular lateral incisor. Histopathological examination showed sheets and lobules of predominantly large round granular cells with eccentric nuclei. Islands and cords of inactive looking odontogenic epithelium formed by two or more rows of epithelial cells, some with clear cytoplasm permeating the granular cells, were also observed. Looking at the less aggressive nature of CGCOT and patient's age, enucleation and thorough curettage via intra-oral approach was done under general anesthesia along with extraction of the associated teeth. The extracted teeth showed apical root resorption. There was no evidence of recurrence after 1 year.

Central Granular Cell Odontogenic Tumor of the Maxilla

The central granular cell odontogenic tumor (CGCOT) is a rare benign odontogenic neoplasm composed of varying amounts of large eosinophilic granular cells and apparently inactive odontogenic epithelium. It tends to occur as a small asymptomatic swelling in the posterior region of the mandible with nonaggressive appearance. We report an unusual case of CGCOT in the maxillary region with clinical features of malignancy. The patient underwent surgical treatment, and the 2-year follow-up revealed no signs of recurrence. Central granular cell odontogenic tumor is a very rare condition with few cases reported, especially in the maxillary region. This case highlights the possibility of aggressive behavior by these lesions.

Tumor Odontogênico de Células Granulares

Introduction: the granular cell odontogenic tumors are an uncommon neoplasm with benign clinical behavior. The lesion occurs over a wide age range with a typically predilection for the mandibular canine and molar regions. Aim: Conclusions: the tumor don’t present an aggressive biological behavior although recurrences can occur. The lesion is treated by conservative surgery with curettage and enucleation as election procedures. present a granular cell odontogenic tumor literature review.

Central odontogenic fibroma with features of central granular cell odontogenic tumor

Much debate exists over the lesions recognized as odontogenic fibromas. In this case report, the authors report 1 lesion that presented with histological features consistent with 2 separate lesions. The findings, histological examination, and recommendations are presented.

Central granular cell odontogenic tumor: a histopathologic and immunohistochemical study

The central granular cell odontogenic tumor (CGCOT) is a rare lesion that usually affects the posterior region of the mandible of young adults. We present a case of CGCOT involving the mandible of a 20-year-old white woman, emphasizing the immunohistochemical characteristics using a large panel of antibodies. The lesion was removed surgically, and after 4 years of follow-up, there are no evidences of recurrences. The odontogenic epithelium (OE) showed positivity for cytokeratins (CKs) AE1/AE3, 34betaE12, CK5, CK7, CK8, CK14, CK19, E-cadherin, beta-catenin, CD138, and p63. The granular cells were positive for vimentin, CD68, lysozyme, muscle-specific actin, alpha-smooth muscle actin, calponin, neuron-specific enolase (NSE), CD138, and bcl-2. Dendritic-like cells surrounding the OE displayed positivity for vimentin, CD1a, S100, CD68, and bcl-2, but it was negative for factor XIIIa, supporting a Langerhans cell phenotype. Ki-67 labeling index was 1.8%, whereas p53 was negative. These data confirm the benign nature of CGCOT, the association of OE with Langerhans cells, and a variable phenotype of the granular cells.

Genetic expression profiling of six odontogenic tumors.

Odontogenic tumors are rare neoplasms arising from the odontogenic apparatus. We aimed to identify molecular characteristics associated with odontogenic tumorigenesis and malignancy. To this end, we investigated the expression level of human genes by using, for the first time in odontogenic tumors, the technique of expression profiling. Gene expression alterations common to all six odontogenic tumors were identified by the use of cDNA microarrays containing 19,000 human cDNAs. Statistical analysis on a subset of 4974 cDNAs present in the biopsies identified 506 distinct genes associated with the tumors (p-value < 0.01). Gene ontology analysis of the cellular processes which were differentially regulated in odontogenic tumors was accomplished by the use of a subset of 1409 annotated genes. Finally, 43 cDNAs differentiated the three malignant odontogenic tumors (ameloblastic carcinoma, clear cell odontogenic tumor, granular cell odontogenic tumor) from the three benign ameloblastoma biopsies (p < 0.01). The identified genes might help us better classify borderline odontogenic tumors.

The central granular cell odontogenic tumor: report of 5 new cases.

This article reports 5 previously unreported cases of central granular cell odontogenic tumor and compares them with 25 cases from the literature. This lesion appears to be an uncommon benign odontogenic neoplasm of uncertain histogenesis; it occurs over a wide age range with a predilection for the mandibular premolar-molar region. Radiographically, it typically manifests as a well-defined unicystic or multilocular radiolucency, although it can be a mixed-density lesion as well. In our series, there was a narrow spectrum of histologic features consisting of fibrous tissue of altering density and cellularity with plentiful numbers of large eosinophilic granular cells, variable amounts of "inactive-appearing" odontogenic epithelium, and the variable presence of calcified tissue resembling cementum or dystrophic calcifications. The ultrastructural and immunohistochemical findings in this study support a mesenchymal origin for the granular cells. One recurrence was documented in the current series in contrast to no recurrences in the literature.

歯原性か粒細胞腫の１例

Granular cell odontogenic tumor is a rare lesion consisting of densely packed granular cells with numerous scattered strands of odontogenic epithelium interspersed throughout the tissue. A case of this tumor arising in the mandible of a 51-year-old man is reported. Radiological examination revealed a welldefined unilocular radiolucency in the left side of the mandibular body. Marginal resection of the mandible was performed under general anesthesia. Histopathologically, the tumor was composed of large, round cells with abundant cytoplasm containing eosinophic granules and nests of odontogenic epithelium. On the basis of these clinical and histopathological findings, we made a diagnosis of granular cell odontogenic tumor of the mandible. We also discuss the pathogenesis of these granular cells.

Central granular cell odontogenic tumor: Case report and review of literature

Central granular cell odontogenic tumor (CGCOT) is a rare lesion that consists of densely packed granular cells with numerous scattered strands of odontogenic epithelium interspersed throughout the tissue.ls2 Initially, this neoplasm was regarded as a variant of ameloblastic fibroma, but later the World Health Organization classification considered CGCOT to possess specific clinical and histopathologic features. They separated this odontogenic tumor from ameloblastic and odontogenic fibroma,2 because it most likely represents a distinct tumor of mesenchymal origin3 The histologic features of the CGCOT have been well documented and discussed in the literature, but its clinical and radiographic features are still controversial.le5 We present a new case of CGCOT with emphasis on its clinical and radiologic features and critically review and analyze previously published case reports.

Central odontogenic fibroma current concepts.

The author reviews current knowledge concerning the central odontogenic fibroma, which at present in incompletely understood, and reaches the following conclusions. 1) The separation of this lesion into simple and WHO types remains valid because they exhibit different histologic features. However, more care should be taken in rendering the diagnosis of the WHO type than in the past; unlike the simple type, it is a fibroblastic lesion. 2) Complex central odontogenic fibroma is a more appropriate term than the WHO type because the WHO does not use the latter term in its 1992 manual. 3) The microscopic distinction of simple odontogenic fibroma from desmoplastic fibroma remains difficult in some cases. 4) The granular cell odontogenic tumor, which has sometimes been referred to as a type of odontogenic fibroma, is a separate entity, although some simple odontogenic fibromas exhibit scattered granular cells. 5) The separation of lesions that have been reported recently as odontogenic fibromas with giant cell reactions from central giant cell granulomas that exhibit foci of odontogenic epithelium requires further study.

Central granular cell odontogenic tumor: A case report including light microscopy, immunohistochemistry, and literature review

Central granular cell odontogenic tumor: A case report including light microscopy, immunohistochemistry, and literature review

Plexiform granular cell odontogenic tumor: Unicystic variant

Plexiform granular cell odontogenic tumor of the mandible has recently been described. The cardinal histopathologic feature, as its name suggests, is a monophasic plexiform pattern of granular cells; the principal tumor in the differential diagnosis is granular cell ameloblastoma. Unlike the two previously reported cases of plexiform granular cell odontogenic tumor, which occurred as solid tumors in elderly men, the lesion reported here is a unicystic variant occurring in a middle-aged woman.