Grant Mechanisms Research Articles

Gender differences in funding among grant recipients in emergency medicine: A multicenter analysis

ObjectiveTo describe differences in funded grants between male and female faculty in two academic emergency departments. MethodsThis was a retrospective analysis of grant funding at two academic emergency departments from January 2012-September 2018. We queried the grants department databases at each institution and obtained records of all funded grants for emergency medicine (EM) faculty. We extracted the following information for each award: gender of the principal investigator (PI), PI academic rank, grant mechanism (government, institutional, industry, organizational), and percent effort. Differences by gender were compared using Chi-square or Fisher’s exact test and Wilcoxon-rank sum. ResultsOne-hundred and thirty grants were awarded to EM faculty at the two institutions during the study period. Of the funded grants, 35 (27%) of recipients were female. Among grant recipients, females held lower academic ranking than males (p-value < 0.001): Instructor (49% vs 51%), Assistant Professor (36% vs 64%), Associate Professor (9% vs 91%), and Professor (0% vs 100%), respectively. Organizational grants were dispersed equally between funded faculty, but females received a fewer government, industry, and institutional grants (p-value = 0.007). Female grant recipients were awarded a higher median percent of effort compared to males (14% [IQR: 3–51] vs 8% [IQR: 1–15], respectively, p-value = 0.023). ConclusionIn this multicenter analysis, gender discrepancies exist among funded grants of EM faculty. Male recipients had higher academic ranking than their female counterparts. Female recipients were less likely to have government, institutional, and industry grants but received a greater percent effort on funding that was awarded.

The Symptoms Self-Management Center (SSMC): Methods for developing and implementing technology-enhanced self-management interventions for pain and fatigue

The National Institutes of Nursing Research provides funding via the P20 grant mechanism for research infrastructure and resources to develop nurse scientists with expertise in symptom self-management. The Medical University of South Carolina College of Nursing was awarded a P20 grant in 2016 to build the Symptoms Self-Management Center for technology-enhanced interventions to address pain and fatigue in individuals with chronic health conditions. Resources were derived from three key subcores: bioinformatics, mHealth and eHealth consultative services, and community engagement. This paper describes methods for deriving specific resources within each subcore, the application of subcore resources in two pilot studies, and lessons learned during the early phases of our Symptoms Self-Management Center implementation.

PRIM: a model case of collaborative governance

That which looks like a road to Directorate General of Highways is a lifeline to citizens, a framework for development for regional government, and a source of livelihood in road construction. These four different perspective of stakeholders form the basis of innovative collaboration in the acclaimed Provincial Road Improvement Program (PRIM) in NTB. Quality of regional roads and road maintenance has vastly improved through the program, and its success lies in collaboration.&#x0D; This paper presents the four perspectives of the collaboration and concludes with lessons learnt. Representatives of each will be present at the IAPA conference presentation.&#x0D; (1) Local government of West Lombok will report how PRIM has resulted, in more productive investment in roads, and also how civil society engagement adds value and how managerial support improves regional government capacity. Local government will also indicate how the grant mechanism, hibah jalan, provides a valuable incentive to improve design and construction quality. (2) A representative of the Forum Lalu Lintas dan Angkutan Jalan, will describe the social inclusion aspects of PRIM, and how the outcomes satisfy real community needs.&#x0D; (3) A representative of the local engineering profession will demonstrate how PRIM enables them to be more professional and how it helps construction companies to gain a better business reputation.&#x0D; (4) The Head of Bina Marga’s subdirectorate for facilitating regional roads describes how observing the excellence of PRIM has led to plans to adopt PRIM practices nation-wide.

Trial Readiness in Cavernous Angiomas With Symptomatic Hemorrhage (CASH).

Brain cavernous angiomas with symptomatic hemorrhage (CASH) are uncommon but exact a heavy burden of neurological disability from recurrent bleeding, for which there is no proven therapy. Candidate drugs to stabilize the CASH lesion and prevent rebleeding will ultimately require testing of safety and efficacy in multisite clinical trials. Much progress has been made in understanding the epidemiology of CASH, and novel biomarkers have been linked to the biological mechanisms and clinical activity in lesions. Yet, the ability to enroll and risk-stratify CASH subjects has never been assessed prospectively at multiple sites. Biomarkers and other outcomes have not been evaluated for their sensitivity and reliability, nor have they been harmonized across sites. To address knowledge gaps and establish a research network as infrastructure for future clinical trials, through the Trial Readiness grant mechanism, funded by National Institute of Neurological Disorders and Stroke/National Institutes of Health. This project includes an observational cohort study to assess (1) the feasibility of screening, enrollment rates, baseline disease categorization, and follow-up of CASH using common data elements at multiple sites, (2) the reliability of imaging biomarkers including quantitative susceptibility mapping and permeability measures that have been shown to correlate with lesion activity, and (3) the rates of recurrent hemorrhage and change in functional status and biomarker measurements during prospective follow-up. We propose a harmonized multisite assessment of enrollment rates of CASH, baseline features relevant to stratification in clinical trials, and follow-up assessments of functional outcomes in relation to clinical bleeds. We introduce novel biomarkers of vascular leak and hemorrhage, with firm mechanistic foundations, which have been linked to clinical disease activity. We shall test their reliability and validity at multiple sites, and assess their changes over time, with and without clinical rebleeds, hence their fitness as outcome instruments in clinical trials. The timing cannot be more opportune, with therapeutic targets identified, exceptional collaboration among researchers and the patient community, along with several drugs ready to benefit from development of a path to clinical testing using this network in the next 5 years.

Survivorship Science at the NIH: Lessons Learned From Grants Funded in Fiscal Year 2016.

Federal investment in survivorship science has grown markedly since the National Cancer Institute's creation of the Office of Cancer Survivorship in 1996. To describe the nature of this research, provide a benchmark, and map new directions for the future, a portfolio analysis of National Institutes of Health-wide survivorship grants was undertaken for fiscal year 2016. Applying survivorship-relevant terms, a search was conducted using the National Institutes of Health Information for Management, Planning, Analysis and Coordination grants database. Grants identified were reviewed for inclusion and categorized by grant mechanism used, funding agency, and principal investigator characteristics. Trained pairs of coders classified each grant by focus and design (observational vs interventional), population studied, and outcomes examined. A total of 215 survivorship grants were identified; 7 were excluded for lack of fit and 2 for nonresearch focus. Forty-one (19.7%) representing training grants (n = 38) or conference grants (n = 3) were not coded. Of the remaining 165 grants, most (88.5%) were funded by the National Cancer Institute; used the large, investigator-initiated (R01) mechanism (66.7%); focused on adult survivors alone (84.2%), often breast cancer survivors (47.3%); were observational in nature (57.3%); and addressed a broad array of topics, including psychosocial and physiologic outcomes, health behaviors, patterns of care, and economic/employment outcomes. Grants were led by investigators from diverse backgrounds, 28.4% of whom were early in their career. Present funding patterns, many stable since 2006, point to the need to expand research to include different cancer sites, greater ethnoculturally diverse samples, and older (>65 years) as well as longer-term (>5 years) survivors and address effects of newer therapies.

FINANCIAL POTENTIAL OF TERRITORIAL COMMUNITIES: MODERN STATE AND PROSPECTS

Introduction. In the context of budget decentralization in Ukraine, local governments are trying to make effective use of their powers and financial potential of the territorial community in order to increase local budget revenues and funding of services at the local level. The purpose is to find out the essence of the financial potential of territorial communities and to analyze its current state in the context of existing and potential sources of financial resources that can be used by local governments for the realization of their goals and perspectives. Methods. To achieve goal, a system of general scientific and special methods of research was used: analysis, synthesis and generalization - in the processing of literary, statistical, legislative and Internet sources on the topic of research; methods of systematizing and generalizing data, comparing and detailing were used when conducting analysis of local budget revenues; graphical, tabular and visualization methods were used for visual representation of the processed data; abstract-logical method was used for summarize the material presented and formulate conclusions. Results. It has been found out that financial potential of a local community is a collection of available and potential sources of financial resources that local governments can attract through budgetary, investment, credit and grant mechanisms to ensure the effective functioning of the community. It is proved that budgetary funds is gradually increasing and prevail in the structure of financial resources of local self-government bodies in Ukraine. Despite the positive dynamics, local budget revenues have not yet become the basis of financial independence of territorial communities, and tax revenues make up 88% of the structure of local budget own revenues. Possibilities of attracting private sector investment funds on the basis of public-private partnership as a potential source of financial resources of territorial communities are analyzed. It has been found out that the sources of growth of the financial potential of local self-government are credits and grants, which provide financing for infrastructure projects for the development of territorial communities. It is proved that the specific reserve of resource provision of territorial communities is human capital, with the participation of which the formation, distribution and use of financial resources of the community takes place. Emphasis is placed on revenues from the disposal of municipal waste as an inexhaustible financial resource of territorial communities. Proposals for increasing the efficiency of utilization of the financial potential of territorial communities at the present stage of development have been developed. Conclusions. The subject of further scientific exploration is the search for and in-depth study of ways to effectively use the financial potential of local communities to improve the quality and accessibility of public services at the local level.

Municipal Social Policy Realization: the Role of Scientific Research (by the Results of the Study in Barnaul, Altai Kray)

The Object of the Study. Municipal social policy.The Subject of the Study. The role of scientific research in realizing municipal social policy.The Purpose of the Study. Identifying the role of scientific research in realizing social policy at the municipal level.The Main Provisions of the Article. The main theoretic methodological and philosophy approaches to the science integration to the social policy realization are analyzed. There is the substantiation of the efficiency of the scientific potential use in the social policy implementation at the local level. Scientific achievements and innovations involvement in solving social problems of the city of Barnaul are considered through the implementation of the grant mechanism of interaction in the municipality. A special contribution of the authors is the analysis of legislation in the field of grant support for research projects, monitoring the efficiency of the competition, as well as the correlation of the results of the grant competition with the directions of social policy at the city level (based on the results of monitoring the implementation of grant forms of support in the city in the period from 2014 to 2017). The main problems have been identified that make it difficult to use the potential of science in the implementation of social policy of the city, namely the lack of strong and extensive network of grant competitions in this area, the "frozen" amount of funding for the competition and weak differentiation in the degree of scientific experience among applicants for the grant. According to the study results the place and role of scientific research in the implementation of the activities of local governments in the city of Barnaul in order to implement social policy have been defined, as well as recommendations to improve this activity for the city management developed.

Prawne aspekty udzielania kredytów denominowanych oraz indeksowanych do waluty obcej

Legal aspects of granting loans denominated and indexed in a foreign currencyThis study addresses the issue of the legality of the denominated and indexed loans in a foreign currency under the current applicable law, with reference to the existing position of doctrine and case law in this area. The starting point for this considerations is the arbitrarily accepted thesis in the public discourse that the credit agreements denominated and indexed in a foreign currency were defective due to their lack of compliance with the applicable law or because their included the provisions that were unfair market practices. This study is an attempt to dispel doubts to the compliance of the loan granting mechanism with the commonly applicable laws in Poland, in particular with the provision of Article 69 of the Banking Law, setting forth the rules of concluding by the bank the credit agreement with the borrowers or a provision of Article 358 § 2 of the Civil Code providing for the possibility of using so-called valorization clauses. This study also delivers opinion of the National Bank of Poland or the Financial Supervision Commission, which very often are deliberately omitted or distorted in the public discourse.

The Role of The Land Deed Officials in Mortgage Right Credit Agreement in PT. Bank Jateng Branch Slawi, Tegal Regency

This study aims to determine the implementation of Credit Agreement with the guarantee of Mortgage Right made by Notary of Land Deed Officials at PT. Bank Jateng Branch Slawi, Tegal Regency, to know the role of Notary Land Deed Officials, to know the constraints faced by Notary and what the solutions can be considered to solve the problem. This legal investigation included a descriptive type of empirical legal research. Research location was at PT. Bank Jateng Branch Slawi, Tegal Regency and the Notary office of Dewi Milasari, S. Sos., S.H., M.Kn as Notary PPAT partner. Based on this research, it found that credit granting mechanism in PT. Bank Jateng Branch Slawi, Tegal Regency is done through 5 stages: stage of loan application, credit analysis, credit decision, credit agreement and credit binding stage. Before credit agreement is executed, Notary as a partner is obliged to check the validity of guarantee of Mortgage Rights, Notary PPAT in credit agreement with guarantee of Mortgage right provides legal certainty for parties holding credit agreement. The constraint faced by Notary in making credit with Mortgage Right is the credit agreement draft which has been prepared by bank (creditor). However, the contents are unfair or more disadvantageous to the customer (the debtor), and the banking party often (creditor) absent in the signing of the deed.Keywords: Role of Land Deed Officials; Credit Agreement; Mortgage Rights

Encompassing Cultural Contexts Within Scientific Research Methodologies in the Development of Health Promotion Interventions.

American Indians/Alaska Natives/Native Hawaiians (AI/AN/NHs) disproportionately experience higher rates of various health conditions. Developing culturally centered interventions targeting health conditions is a strategy to decrease the burden of health conditions among this population. This study analyzes characteristics from 21 studies currently funded under the Interventions for Health Promotion and Disease Prevention in Native American (NA) Populations program among investigators currently funded under this grant mechanism. Four broad challenges were revealed as critical to address when scientifically establishing culturally centered interventions for Native populations. These challenges were (a) their ability to harness culture-centered knowledge and perspectives from communities; (b) their utilization of Indigenous-based theories and knowledge systems with Western-based intervention paradigms and theories; (c) their use of Western-based methodologies; and (d) their cultural adaptation, if based on an evidence-based treatment. Findings revealed that qualitative methodologies and community-based participatory research (CBPR) approaches were very commonly used to finalize the development of interventions. Various Indigenous-based theories and knowledge systems and Western-based theories were used in the methodologies employed. Cultural adaptations were made that often used formative mixed qualitative and quantitative methods. Illustrative examples of strategies used and suggestions for future research are provided. Findings underscored the importance of CBPR methods to improve the efficacy of interventions for AI/AN/NH communities by integrating Indigenous-based theories and knowledge systems with Western science approaches to improve health.

SD-EAR: Energy Aware Routing in Software Defined Wireless Sensor Networks

In today’s internet-of-things (IoT) environment, wireless sensor networks (WSNs) have many advantages, with broad applications in different areas including environmental monitoring, maintaining security, etc. However, high energy depletion may lead to node failures in WSNs. In most WSNs, nodes deplete energy mainly because of the flooding and broadcasting of route-request (RREQ) packets, which is essential for route discovery in WSNs. The present article models wireless sensor networks as software-defined wireless sensor networks (SD-WSNs) where the network is divided into multiple clusters or zones, and each zone is controlled by a software-defined network (SDN) controller. The SDN controller is aware of the topology of each zone, and finds out the optimum energy efficient path from any source to any destination inside the zone. For destinations outside of the zone, the SDN controller of the source zone instructs the source to send a message to all of the peripheral nodes in that zone, so that they can forward the message to the peripheral nodes in other zones, and the process goes on until a destination is found. As far as energy-efficient path selection is concerned, the SDN controller of a zone is aware of the connectivity and residual energy of each node. Therefore, it is capable of discovering an optimum energy efficient path from any source to any destination inside as well as outside of the zone of the source. Accordingly, flow tables in different routers are updated dynamically. The task of route discovery is shifted from individual nodes to controllers, and as a result, the flooding of route-requests is completely eliminated. Software-defined energy aware routing (SD-EAR)also proposes an innovative sleeping strategy where exhausted nodes are allowed to go to sleep through a sleep request—sleep grant mechanism. All of these result in huge energy savings in SD-WSN, as shown in the simulation results.

Neuroimaging and neuropsychological assessment of freezing of gait in Parkinson's disease

IntroductionFreezing of gait (FOG) is a disabling phenomenon characterized by a brief, episodic absence or reduction of forward progression of the feet despite the intention to walk. It is a common cause of falls and mortality in cases with Parkinson's disease (PD). This article reviews neuropsychological and neuroimaging studies to date and introduces a new study of multimodal imaging and cognition in PD-FOG. MethodsA comprehensive literature search identified studies using neuropsychological evaluation and/or neuroimaging to evaluate PD-FOG. ResultsSeveral studies have evaluated PD-FOG, but few have combined neuropsychological and comprehensive neuroimaging and none longitudinally. DiscussionA study using a combined approach longitudinally evaluating cognitive dysfunction and underlying neural networks in FOG is needed. We introduce the framework of a study which demonstrates the use of establishing an infrastructure for studying neurodegenerative disorders using the National Institutes of Health/National Institute of General Medical Science Center of Biomedical Research Excellence grant mechanism.

Does system of local government subsidisation fulfil revenue equalisation function? Evidence from Poland

Research background: General grants in the system of local government finance should pursue five different functions. One of them is revenue equalization. This function is achieved if the revenue gap is reduced after the application of the subsidising mechanism. In addition, to be completed, the size of the support should be inversely proportional to own revenues.&#x0D; Purpose of the article: The aim of the article is to analyse the fulfilment of the revenue equalization function by general grants. Therefore, beside the theoretical analysis, which presents the general grants structure and the functions assigned to them, the article discusses the results of studies showing changes in the revenue gap after the application of the grant mechanism and the correlation between per capita own revenue and the amount of funds from selected parts (equalisation, balancing-regional, reserve, compensating) of the general grant. The following tentative research hypothesis was adopted: general grants fail to fulfil the revenue equalisation function.&#x0D; Methods: Two research methods were applied to achieve the aim of the article and verify the research hypothesis: descriptive statistics and correlation ? calculating the Pearson correlation coefficient.&#x0D; Findings &amp; Value added: Based on the analyses, it was concluded that, once the corrective and equalising mechanism was applied, the range between the extreme per capita revenue values was reduced by 40?50% on average, at all local government levels, i.e. at commune (including cities with county right), county and province levels, in each year from the period analysed, i.e. 2012?2016. The correlation between the sizes of revenue before and after budget subsidising is always negative, whereas the strength of the relationship ranged between low and significant, depending on the local government level. It was found that general grants do fulfil the revenue equalisation function, which contradicts the initially formulated research hypothesis.

Resource Development and Sámi Rights in the Sápmi Region: Integrating Human Rights Impact Assessment in Licensing Processes

In recent years, the Sápmi region has witnessed an expansion of resource extraction activities. The enjoyment of human rights of the Sámi indigenous people will likely be challenged by extractive industries, unless effective measures are implemented to mitigate the possible effects of these activities. In this article, we explore the possibility of integrating human rights impact assessment (hria) in license granting mechanisms such as environmental impact assessment (eia). Our goal is to explore what international standards are available for conducting hrias and whether these would bring benefit to license granting processes. Based on our analysis, we recommend that the integration of hrias, particularly concerning Sámi rights, in response to resource developments in the Sápmi region, would on one hand bring a stronger normative value to such processes, offering a greater legal protection for Sámi, and on the other hand offer strengthened trust between communities and the companies, in resource extractions.

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OBJECTIVES/SPECIFIC AIMS: To analyze how consumer physical activity monitors are currently used in biomedical research. METHODS/STUDY POPULATION: Searches were conducted in Ovid Medline, PubMed Medline, clinicaltrials.gov, and NIH RePORTER using search terms including Fitbit, Jawbone, Apple watch, Garmin, Polar, Microsoft band, Misfit, Nike, Withings, and Xiaomi. Results were quantitated by category: condition/topic, intervention, enrollment status, study type and design, age, grant mechanism, and primary outcome. RESULTS/ANTICIPATED RESULTS: Fitbit is used &gt;80%. There are 127 clinical studies using Fitbit devices listed in clinicaltrials.gov. In total, 48 have been completed while 79 are ongoing. Some studies have already published their findings; 40 papers cited in Ovid MEDLINE report use of a Fitbit device. NIH is now funding research that uses consumer physical activity monitors, and the NIH RePORTER shows the number of grants using Fitbit is rapidly increasing. DISCUSSION/SIGNIFICANCE OF IMPACT: The current state and potential growth of this technology is transforming biomedical research and is enabling us to ask new and more granular questions about activity and sleep in health and disease.

Ed Carstensen, advisor and mentor to the shockwave lithotripsy program project group

In the 1980s shockwave lithotripsy emerged as a revolutionary advancement for the treatment of kidney stones. Initial studies with patients showed SWL to be highly effective. The technology was elegant, outcomes exceptionally positive and early tests suggested treatment was safe. As experience with SWL grew, limitations surfaced. A key finding was that SWs have the potential to induce significant trauma to the kidney. Our group convinced the NIH it was time to conduct a rigorous assessment to characterize the adverse effects of SWL and determine the mechanisms of SW action in stone breakage and tissue injury. The NIH Program Project Grant mechanism mandated we establish a panel of external advisors to help guide our work. We needed expertise in physical acoustics, cavitation and animal models of ultrasound exposure. We wanted a leading expert. We were extremely fortunate to land Ed Carstensen. Ed worked with us for nearly 15 years, well into our third renewal cycle. He was a brilliant scientist, a man ded...

The Australian experience in using tenders for conservation

Over the past 15 years Australia has been trialling conservation tenders and other market based instrument approaches to generate environmental outcomes, particularly on private lands. The best known of these is the BushTender auction for vegetation protection in Victoria, begun in the early 2000s. Subsequently, nearly 100 other tenders for biodiversity protection have been run in Australia with substantial variations in application and methodology generated by a mix of both intended design and case study differences. The number of separate conservation tenders that have been performed, and the variations in environmental targets, state jurisdictions, case study circumstances, design and implementation, provides a rich data base of projects for analysis – unique at the international level.The review section of the paper covers three broad areas. The first aim is to provide an overview of the various tenders and their history and design in different settings. The second is to review their application, particularly in relation to auction design, metric design and contract design aspects, while the third is to identify the extent to which tenders provided more cost-effective outcomes than alternatives such a fixed rate grants. An additional goal is to explain why, after so many trials, conservation tenders are not more widely used in Australia. Key conclusions are that the multiple trials show that tenders are robust, relatively simple to apply and deliver more cost-effective allocations of public funding than other grant mechanisms. The reasons for their limited use can be related more to political and bureaucratic forces and inertia rather than to economic and design limitations.

Identifying the internal structure evolution of urban built-up land sprawl (UBLS) from a composite structure perspective: A case study of the Beijing metropolitan area, China

Differences in the internal composite structure during urban built-up land sprawl (UBLS) will generate different effects, and thus, a city’s spatial structure has important bearings on urban sustainability. This study investigates the spatial and temporal characteristics of the internal structure and allocation relationship of UBLS using multivariate spatial correlation and the Weaver-Tomas composite coefficient based on site data of granted built-up land parcels. Moreover, the composite structure evolution process of UBLS and its driving mechanism are examined in this study. The results reveal that the amount structure of the three types of UBLS (i.e. industrial land sprawl, residential land sprawl and commercial land sprawl) tended to be balanced during the study period. Following the transformation and upgrade of the urban industry structure, the overall composite structure of UBLS ranged from single residential land-use structure (Res.) to industrial-residential land-use structure (Ind.-Res.) In the early period of land marketization, the marketization land granting mechanism caused low spatial correlation between the various types of UBLS and a single composite structure, i.e. Res., single commercial land-use structure (Com.), and residential-commercial land-use structure (Res.-Com.). Subsequently, a dual-driving force including the market economy and government interventions caused a relatively high degree of spatial correlation and a multiple composite structure, i.e. Ind.-Res. and industrial-residential-commercial land-use structure (Ind.-Res.-Com.). However, the evolution characteristics of the composite structure in various regions illustrate some problems, such as the spatial isomorphism phenomenon of the composite structure and the dislocation of urban built-up land allocation. The urban internal built-up land spatial layout pattern is the embodiment of two dominant driving forces, the market and the government, interacting with each other according to natural and socioeconomic conditions. Therefore, we suggest that it is necessary to reform the future urban built-up land granting mechanism based on market guidance, and the composite structure of UBLS should be adjusted according to the regional function. The government should reinforce the macro-control of land-use planning for the dispersed granted land parcels so as to optimize the urban land-use structure.

Beyond Ageist Attitudes: Researchers Call for NIH Action to Limit Funding for Older Academics.

This article explores manifestations of ageism in response to a proposed National Institutes of Health (NIH) Emeritus Grant initiative aimed at funding older investigators. Comments were requested by NIH in 2015, through a Request for Information (RFI) as well as a public blog regarding the merits of a proposed grant mechanism that would help older researchers transfer their labs to junior scientists and transition into retirement. This article reports content analysis of comments from 134 respondents to the blog. We found consistent patterns of disapproval of the proposed NIH initiative, which was viewed by most respondents as an undeserved benefit for older scientists. Negative attitudes were also expressed toward senior investigators by a large majority of commenters. In addition to broad opposition to new grant funding for senior investigators, many commenters also advocated for other punitive actions toward older investigators, including forced retirement. These opinions were generally justified by negative appraisals of senior investigators' competence, productivity, and even their character. Ageist comments were not limited to younger researchers, suggesting potential internalized ageism by older investigators. We discuss manifestations of ageism and advocacy for age discrimination in the broader social context of modernization theory, intergenerational conflict and social closure. Our findings raise important questions about the limited value of higher education in counteracting prejudice toward older people. We propose potential remedies to reduce ageism in academia.

Grant Writing Tips for Translational Research.

All investigators face the same challenge-the highly competitive nature of the grant review process. Innovation alone is not enough to ensure grant-supported funding. Applied clinical research requires a diverse, collaborative team of investigators with specialized skills, a supportive clinical research environment, and access to clinical material. Additionally, the lack of animal models for many diseases and ethical limitations prevent direct mechanistic experiments that are possible using in vitro systems or animal models. Therefore, specific granting mechanisms and program initiatives target translational research studies. This chapter provides grant writing tips and lists resources that may prove helpful for new investigators seeking research funding in support of translational research, biobanking, and research utilizing molecular biomarkers.