Numerous Mesozoic granitoid plutons with a substantial variety of petrologic and geochemical signatures intrude the Triassic metasedimentary rocks of the Songpan-Ganze accretionary-orogenic wedge in the eastern Tibetan Plateau. These granitoid rocks generally exhibit sharp contact with the Triassic sedimentary rocks. To better understand the genesis and emplacement of magmas associated with tectonic accretion along convergent plate boundaries, we present new LA-ICP-MS zircon U-Pb geochronology, major and trace elements, and Sr–Nd–Pb–Hf isotopic compositions for intermediate-to-felsic plutons in the Yajiang gneiss dome group (YGDG), including the Changzheng pluton, the Jiajika (Majingzi) pluton, the Rongxuka pluton, the Xiya pluton, the Xinduqiao pluton, and the Waduo diorite dikes in the eastern margin of the Songpan-Ganze orogenic belt (SGOB). By their typical petrological and geochemical characteristics, these plutons are classified as I-type granodiorite-diorite (Rongxuka, Xiya, Xinduqiao plutons, Waduo dikes) or S-type granite (Changzheng and Jiajika plutons). I-type granodiorite-diorites exhibit a high Mg# (average 49), medium-K cala-alkiline signature and are enriched in large-ion lithophile elements (e.g., Rb, Th, and U) but depleted in high field strength elements (e.g., Nb, Ta, and Ti), and with lower initial 87Sr/86Sr values (0.70622 to 0.70863) but a relatively high and concentrated εHf(t) (−27 to −1.9) and εNd(t) (−4.02 to −7.51); while S-type granites exhibit a high silica, high-K cala-alkiline signature with strong negative Eu anomalies (Eu/Eu* = 0.17–0.64), and possess high initial 87Sr/86Sr values but low εHf(t) (−40.1 to −0.9) and εNd(t) (−8.72 to −12.14) signatures, forming through partial melting of metasedimentary rocks from an ancient crust source. LA–ICP–MS zircon U-Pb dating indicates that they were emplacement between 207.2 ± 1.4 and 223.6 ± 2.2 Ma. Both types of granitoid rock were formed by the crustal partial melting followed by extensive fractional crystallization under high-temperature (700–850 °C), low-pressure (<15 kb) conditions. In combination with previous studies, our data provide evidence for an affinity between the eastern Songpan-Ganze andthe Yangtze craton basements, and suggest that the granitoid plutons formed in a syn-collisional to post-collisional setting at ca. 207–223 Ma.