This thesis argues that the Genesis 3:15 reveals a historical progression to hostility and competition between the snake and the woman, as well as between their offspring, which is exemplified by the enmities between Cain and Abel, Noah and Ham, Abraham and Lot, Jacob and Esau, Jacob's sons and Shechem, and Joseph. This thesis uses the Historical-grammatical approach to analyze Genesis, showing how the subject of hostility evolved throughout the book. It assumes that if the context of the text calls for it, there is sufficient latitude to employ other strategies. The thesis's understanding of enmity is informed by אֵיבָה (enmity), which is used in the LXX (ἔχθρα) to refer to foes in conflict among gentiles and personal enemies. The word study supports the idea that family animosity eventually turns into national animosity between Israel and other Canaanite countries. The discussion of animosity in Gen. 3:15 is divided into three parts: first, the serpent's attempt to get close to the woman ends in enduring hostility, second, the animosity that started with the woman and the serpent will be carried on by their offspring, and third, this conflict needs to be viewed in a progressive manner.