Gram Of Powder Research Articles

Optimisation of seed oil and powder of Momordica charantia in the formulation of body scrub cream

Background: Momordica charantia seed oil and powder are potential ingredients for a body scrub. The seeds contain fatty acids to moisturise the skin, and the mineral content to remove dead skin cells and nourish the skin. Objective: To determine the optimal efficiency of Momordica charantia seed oil and powder on body scrub cream produce. Methods: The body scrub used W/O (water-in-Oil) cream base. Simplex Lattice Design was used to determine five formulas. The irritation test with the Draize Skin Test method was carried out on rats (n = three, in each formula), and the Primary Dermal Irritation Index (PDII) was calculated. Informed consent from the female participants has been obtained for the hedonic test. Results: The body scrub cream produced appropriate organoleptic, was not irritating, and was stable after centrifugation and cycling test. The optimum formula contained five grams of oil and one gram of powder with a pH of 5.21; viscosity of 205.33 dPa.s; spreading of 6.12cm; adhesion time of 19.86 seconds; rate of washing of 20.60 seconds; a colour value of 4.04; scent value of 2.90; and texture value of 2.98. Conclusion: The optimised body scrub cream yielded a good formula which can be developed as a body scrub preparation.

Prevalence of House Dust Mites and Presence of Der p 1 and Der f 1 in Ordu, Giresun, Trabzon and Rize Provinces.

This study was carried out to detect house dust mites in houses and to investigate group 1 antigens of Dermatophagoid species in Ordu, Giresun, Trabzon and Rize provinces of the Central and Eastern Black Sea Region. Dust samples obtained from the beds were subjected to both microscopic and antigenic examination. Samples prepared by the lactic acid method for microscopic examination were evaluated under a light microscope. Antigenic analysis was performed by investigating Der p 1 and Der f 1 belonging to D. pteronyssinus and D. farinae by ELISA test. 90.3% of the dust samples were evaluated positive by microscopic examination (10x, 40x) and 149 mites were detected. D. pteronyssinus 74%, D. farinae 13%, Dermatophagoides spp. growth forms 5%, Cheyletus spp. 1%, E. maynei 1%, C. arcuatus 1%, T. putrescentiae 1%, L. destructor 1% and unidentified mites were detected at the rate of 3% respectively. Der p 1 antigen was detected in 93% and Der f 1 antigen in 84.7%. The highest amount of antigen detected in one gram of powder was 1,272 μg for Der p 1 and 0,482 μg for Der f 1. No difference was observed between mite species and distribution in the provinces where the study was conducted (p<0.05). Dermatophagoides were found in 93% of the population. The low (4%) rate of storage/food mites is related to the fact that samples were not taken from the floors. Antigen accumulation may be important in the beds since the activity of the mites is observed throughout the year in temperate and humid regions. It is thought that this diagnosis method can be used and can be taken into account in terms of the environments in which sensitive people live.

Secagem da polpa de butiá pelo método de camada de espuma e caracterização do pó obtido

Abstract The objective of this work was to develop a drying process using the foam-layer method to obtain the powder from butiá (Butia spp.) pulp, as well as to characterize this powder according to its yield and physicochemical and technological characteristics. The foam was optimized for density and stability by varying whipping times and albumin and xanthan gum concentrations. Foam drying was optimized for vitamin C retention and yield using different foam thicknesses and drying temperatures. The optimized foam showed a density of 0.25 g cm-3 and a high stability, being suitable for subsequent drying. The lowest foam thickness (0.50 cm) and the highest drying temperature (80°C) resulted in the highest retention of vitamin C, whereas the increase in drying temperature improved yield. The butiá pulp powder obtained under the optimized condition presented an acid pH of 3.25, a low humidity of 7.97%, a water activity of 0.206, a water retention capacity of 4.90 g H2O per gram of powder, a solubility of 74.40%, a soluble solids content of 61°Brix, and a predominantly yellow color. The foam-layer drying method can be used to obtain butiá pulp powder.

Anti-cariogenic &amp; Cytotoxic Activity of Red Sandal (Pterocarpus santalinus) Ethanolic Extract

Introduction: Pterocarpus santalinus, with the common names red sanders, red saunders, red sandalwood, Rakt Chandan, and saunderswood, is a species of Pterocarpus endemic to the southern Eastern Ghats mountain range of South India. This tree is valued for the rich red colour of its wood.The use of ethanolic extract is a cost-effective way to produce a quality extract from a large volume of plants.Pterocarpus santalinus has a characteristic anti-cariogenic and cytotoxic activity.This study aimed to find the Anti cariogenic and cytotoxic activity of Pterocarpus santalinus (Red sandal) ethanolic extract preparation.&#x0D; Materials and Methods: The anticariogenic activity was done by using agar well diffusion technique and the cytotoxic activity was done by Brine Shrimp Lethality Assay. Pterocarpus santalinus were purchased commercially from an herbal health centre, in Chennai. The obtained powder Pterocarpus santalinus stored in an airtight container. 5 gram of powder is mixed with 50 ml of ethanol and kept in the orbital shaker for 72 hours , after it has boiled in a heating mantle at 62- 70 degree c for 5-10 min. The extract is filtered using whatman filter paper 1.The filter extract again contracted using heating mantle.&#x0D; Results: The extract shows very good anticariogenic and cytotoxic activity of P.santalinus ethanolic extract by using Brine Shrimp Lethality Assay.&#x0D; Conclusion: The Anti-cariogenic and cytotoxic activity of Pterocarpus santalinus ethanolic extract preparation was effective.

Anti-Inflammatory Activity of Cassia auriculata Flower Extract

Introduction: Medicinal plants have provided recent medicines with numerous plant derived therapeutic agents. Avaram is extremely valued in Indian medicines for management of painful inflammation and diabetes. The target of this study was to measure the anti-inflammatory potential of Cassia auriculata flowers extract. The anti-inflammatory activity was evaluated using albumin denaturation assay, proteinase inhibitory activity and membrane stabilization at different concentrations. Aspirin and Voltaren were used as standard drugs. The share of inhibition was compared with those of normal drugs&#x0D; Materials and Methods: BSA and EAA assay was used to test the anti-inflammatory activity of plant extract. Cassia auriculata were purchased commercially from an herbal health centre in Chennai. The obtained powder Cassia auriculata is stored in an airtight container. 5 gram of powder is mixed with 50 ml of ethanol and kept in the orbital shaker for 72 hours, after it has boiled in a heating mantle at 62- 70 degree c for 5-10 min. The extract is filtered using whatman filter paper 1. The filter extract again contracted using heating mantle.&#x0D; Results: The extract shows very good antiinflammatory activity for the Cassia auriculata extract by using BSA and EAA Assay.&#x0D; Conclusion: The antiinflammatory activity of Cassia auriculata ethanolic extract preparation was effective.

Pterocarpus santalinus Ethanolic Extract Preparation and Its Free Radical Scavenging Activity

Introduction: Pterocarpus santalinus commonly known as Red sanders, is a member of the Fabaceae family. It is endemic to India and is classified as internationally endangered, with illegal harvesting posing a significant concern. The plant is known for its distinctive wood, which has great colour, beauty, and technical features. The red wood produces santalin, a natural dye that is used to colour pharmaceuticals and foodstuffs. The decoction made from the heartwood is said to have a variety of therapeutic characteristics in traditional medicine. It's been used to induce vomiting as well as treat eye illnesses, mental disorders, and ulcers.&#x0D; Aim: This study aimed to find the free radical scavenging activity of Pterocarpus santalinus ethanolic extract preparation.&#x0D; Materials and Methods: DPPH and H202 Assay was used to test the antioxidant activity of plant extract. Pterocarpus santalinus were purchased commercially from an herbal health centre,in Chennai. The obtained powder Pterocarpus santalinus stored in an airtight container. 5 gram of powder is mixed with 50 ml of ethanol and kept in the orbital shaker for 72 hours, after it has boiled in a heating mantle at 62-70℃ for 5-10 min. The extract is filtered using whatman filter paper 1.The filter extract again contracted using heating mantle.&#x0D; Results: The extract shows very good antioxidant activity for the P.santalinus extract by using DPPH and H202 Assay.&#x0D; Conclusion: The free radical scavenging activity of Pterocarpus santalinus ethanolic extract preparation was effective.

Intra-bone nuclear DNA variability and STR typing success in Second World War 12th thoracic vertebrae

Bones are an important source of DNA for identification in forensic medicine, especially when the remains are skeletonized, which is the case when dealing with victims of the Second World War. Often the amount of bone available for sampling is limited, and therefore it is crucial to sample the bone segment with the highest adequate DNA quantity for identification. Studies performed on all representative skeletal element types of the human body showed that the amount of DNA obtained from different skeletal elements of different body regions varies greatly. When bones from torso were analyzed, thoracic vertebrae outperformed other vertebrae (cervical and lumbar) and, alongside the first ribs, were among the most appropriate bone elements for identification purposes. It was also shown that the quantity of DNA varies significantly within a single bone type. This study focused on exploring intra-bone DNA variability between five parts of 12th thoracic vertebrae (laminae + spinous process, pedicles + transverse processes, and corpus right, left, and middle). The research was based on the theory that the distribution of body weight and consequently bone remodeling, as well as the ratio between cancellous and cortical bone, contribute to different quantities of DNA in different parts of vertebra sampled. The vertebrae were cleaned and cut into five parts, and each part was completely ground to obtain homogenous bone powder. Half a gram of powder from each part was decalcified using a full demineralization extraction method. The DNA was purified in a Biorobot EZ1 machine (Qiagen). DNA quantity and quality were determined using the PowerQuant System (Promega) and autosomal STR typing success using the GlobalFiler Amplification Kit (Applied Biosystems). Thirty-five 12th thoracic vertebrae were sampled from a single Second World War mass grave. The best results with the highest DNA quantity were found in laminae and the spinous process, and among them all vertebrae analyzed yielded full STR profiles except three, where only a few dropouts occurred. The second-ranked bone part was the pedicles and transverse processes. The comparison of DNA degradation in the vertebral segments analyzed does not show statistically significant differences. Considering our research, when only the torso is available for identification, the 12th thoracic vertebra should be collected and the vertebral arch should be sampled for genetic analyses.

Effects of Potato By-products Containing Glycoalkaloid on Rumen Fermentation Characteristics

The present study was conducted to investigate the effects of feed types (powder vs. pellet) from potato by-product containing glycoalkaloid on rumen fermentation with different rumen pH (low vs. high) using in vitro technique. Rumen fluid was collected from two cannulated Hanwoo heifers before morning feeding (high rumen pH at 6.71) and 3 h after feeding (low rumen pH at 6.20). A 0.5 gram of powder or pellet from potato by-product was incubated in the rumen buffer for 48 h at 39℃. Four replications for each treatment were used along with two blanks. Pellet had higher (p<0.05) the immediately degradable fraction, the fractional degradation rate, and the lag phase than those of powder. However, feed type had no effects on the potentially degradable fraction and the total degradable fraction. In fermentation characteristics, powder had higher (p<0.05) concentrations of ammonia-N, total volatile fatty acid (VFA), and acetate than those of pellet. In addition, a high rumen pH had higher (p<0.05) concentrations of ammonia-N and acetate, but lower (p<0.05) total VFA concentration than those of a low rumen pH. The interaction effects between feed type and rumen pH were found on the total degradable fraction and concentrations of ammonia-N, total VFA, and acetate. The present study concluded that generally feed type had no effects on rumen degradation kinetics, but potato by-product in the powder form is recommended due to produce higher fermentation characteristics than in the pellet form.

ENRIQUECIMIENTO DE LACTOFERRINA MEDIANTE UN PROCESO SIMPLE BASADO EN EXTRACCIÓN EN FASE SÓLIDA

Bovine whey is a promising by-product of cheese-making processes, which one can be extracted high-value compounds, like lactoferrin (Lf). This protein has biological activity, such as antimicrobial, anti-inflammatory and anti-cancer effects. Several methods have been proposed to separate Lf from whey, including ultrafiltration or chromatography affinity. In this work, extraction of Lf was proposed, which was carried out using a matrix of polyacrylamide (PAM) activated with Cu (II) to improve its affinity to lactoferrin. Matrices were prepared with two different %T concentrations (6 and 10); these were characterized, and PAM 10%T showed higher entropy values (higher homogeneity), therefore, it was modified with cupric ion and used in the subsequent extraction stages. FT-IR and SEM analysis supported the functionalization of matrix PAM 10%T; likewise, the role of the copper ion in the extraction procedure. According to SDS-PAGE results, PAM (10%T)-IDA-Cu2+-imidazole enabled to reach a lactoferrin recovery around 82.5%; besides, a Lf-enriched fraction (150 µg per gram of powder) was obtained. The method proposed represents an adequate alternative for the recovery of lactoferrin from bovine whey, which is considered a problematic waste.

Highly potent fentanyl analogs: apnea from exposure to small quantities of ß-hydroxyfentanyl and furanylfentanyl

Context: Fentanyl analogs are synthetic opioids that bind to mu receptors with high potency. We report two cases where users developed apnea and required naloxone reversal after exposure to small quantities of the fentanyl analogs, furanylfentanyl and ß-hydroxyfentanyl.Case details: A 19 year-old woman reported insufflating a small number of granules of “fentanyl” powder and developed apnea. A 22 year-old woman touched her tongue to powdered “fentanyl” to treat a migraine headache and became apneic.Results: Furanylfentanyl was identified in the first patient’s serum (3.6 ng/mL furanylfentanyl), urine (17.6 ng/mL furanylfentanyl) , and in the product (109mg/g powder). ß-hydroxyfentanyl was detected in the second patient’s serum (6.5 ng/mL ß-hydroxyfentanyl) and in the product (120 mg/g powder).Discussion: In both cases, furanylfentanyl and ß-hydroxyfentanyl were identified in the serum/plasma and urine. Fentanyl analogs were detected in the product at 109-120mg per gram of powder, which suggests that a 500mcg dose of fentanyl analog is the equivalent to 4.17–4.59mg of powder, or about the mass in 1/500th of a packet of sugar. Unique aspects of these cases are the rarely reported use of furanylfentanyl and ß-hydroxyfentanyl, intentional insufflation of “fentanyl” for therapeutic and recreational use, the small quantities of powder ingested, and the use of non-targeted analysis to identify the fentanyl analogs.

Lead Content of Sindoor, a Hindu Religious Powder and Cosmetic: New Jersey and India, 2014-2015.

To assess the extent of lead content of sindoor, a powder used by Hindus for religious and cultural purposes, which has been linked to childhood lead poisoning when inadvertently ingested. We purchased 95 samples of sindoor from 66 South Asian stores in New Jersey and 23 samples from India and analyzed samples with atomic absorption spectrophotometry methods for lead. Analysis determined that 79 (83.2%) sindoor samples purchased in the United States and 18 (78.3%) samples purchased in India contained 1.0 or more micrograms of lead per gram of powder. For US samples, geometric mean concentration was 5.4 micrograms per gram compared with 28.1 micrograms per gram for India samples. The maximum lead content detected in both US and India samples was more than 300 000 micrograms per gram. Of the examined US sindoor samples, 19% contained more than 20 micrograms per gram of lead (US Food and Drug Administration [FDA] limit); 43% of the India samples exceeded this limit. Results suggested continued need for lead monitoring in sindoor in the United States and in sindoor carried into the United States by travelers from India, despite FDA warnings.

A Green Route for Copper Ions Removal from Textile Industry Effluent

The adsorption of copper(II) on tea waste has been studied in batch mode using flame atomic absorption spectroscopy for metal estimation. Important process parameters like adsorbent dose, pH, contact time, reaction temperature, shaking speed and particle size were investigated. Adsorption was found to be in accordance with Freundlich and Langmuir isotherms. The maximum amount of copper(II) adsorbed (qm), as evaluated by Langmuir isotherm, was approximately 1.33 mg per gram of powder of tea waste per litre of solution. The optimized process parameters were observed to be 3 g adsorbent, pH 5, 40°C temperature, 120 rpm shaking speed and 150 μm particle size. The effectiveness of tea waste for copper removal from industrial effluent was observed to be around 95.345%. The used tea waste after adsorption produced 51.76% methane as biofuel.

Adsorptive Removal of CO&lt;sup&gt;2+&lt;/sup&gt; and Ni&lt;sup&gt;2+&lt;/sup&gt; by Peels of Banana from Aqueous Solution

The aims of the study were to investigate the effect of Banana peel on adsorption of Co 2+ and Ni 2+ by using flame atomic absorption spectroscopy (FAAS) for metal estimation. The effects of Co 2+ and Ni 2+ ions concentration, agitation time and temperature on adsorption of heavy metals onto Banana Peel was investigated. The experimental isotherm results were fitted using Langmuir and Freundlich equations. The Langmuir and Freundlich model agrees very well with experimental data. The maximum amounts of Co 2+ and Ni 2+ + adsorbed (qm), as evaluated by Langmuir isotherm, were 9.02 mg and 8.91 per gram of powder of Banana peel, respectively. Study concluded that Banana peels, a waste material, have good potential as an adsorbent to remove toxic metals like Co 2+ and Ni 2+ from water.

Removal of Pb(II) and Cd(II) from water by adsorption on peels of banana

The adsorption of lead(II) and cadmium(II) on peels of banana has been studied in batch mode using flame atomic absorption spectroscopy for metal estimation. Concerned parameters like adsorbent dose, pH, contact time and agitation speed were investigated. Langmuir, Freundlich and Temkin isotherms were employed to describe adsorption equilibrium. The maximum amounts of cadmium(II) and lead(II) adsorbed ( qm), as evaluated by Langmuir isotherm, were 5.71 mg and 2.18 mg per gram of powder of banana peels, respectively. Study concluded that banana peels, a waste material, have good potential as an adsorbent to remove toxic metals like lead and cadmium from water.

Analysis of a Simple Test Device for Tribo‐Electric Charging of Bulk Powders

AbstractWe have developed a simple device to characterise the tribo‐electric charging propensity of powders. A sample of around one gram of powder is shaken in a container by reciprocal strokes in a horizontal direction. The electric charge on the powder is quantified by a Faraday cup before and after shaking. In this paper, we analyse the operation of this simple test device by investigating the behaviour of α‐lactose monohydrate (α‐LM), hydroxy propyl cellulose (HPC) and a 50 : 50 binary mixture (by mass) of these two powders with various container surfaces commonly used in the pharmaceutical industry. The experiments are carried out in controlled environmental conditions and using different shaking times and frequencies of 10, 20 and 30 Hz. The experimental results show that the saturated charge is independent of the shaking frequency. Furthermore adhered particles coating the inner surface of the shaking container decrease the net amount of charge generated by up to 50 %.

Foam and drop penetration kinetics into loosely packed powder beds

Foam granulation is a new liquid delivery method for wet granulation, where the liquid binder is delivered as an aqueous foam, rather than as an atomised spray to the powder bed. This paper reports for the first time the similarities and differences between wet granulation via foamed and sprayed binder addition methods. The kinetics of single foam and single drop (of HPC and HPMC solutions) penetrations into loosely packed powder beds (of glass ballotini and lactose powders) were studied. Specific penetration time (defined as penetration time per unit of binder mass) and nucleation ratio (defined as the ratio of nuclei granule mass to liquid binder mass) were compared between foam and drop nucleation methods. The impact of particle size and binder concentration on both parameters was also studied. The results indicate that the foamed binder addition method allows a greater mass of binder fluid to be absorbed into the particle bed and uses less liquid binder to nucleate the same number of gram of powder, which indicates improved nucleation efficiency compared to the drop addition method.

Potential Biofumigation Effects of Brassica oleracea var. caulorapa on Growth of Fungi

AbstractBiofumigation, as an environment‐friendly alternative to methyl bromide is gaining attention in sustainable agricultural production systems. Based on the biofumigation suppression of growth of three soil‐borne filamentous fungi (Fusarium sp., F. oxysporum and P. aphanidermatum), Brassica oleracea var. caulorapa was selected from eight Brassica and other plant species as a potential material for the purpose. Powdered tissues of plants were confined to individual Petri dishes without physical contact with each of the following 28 fungal isolates from 16 hosts: 13 Fusarium spp., two Verticillium dahliae, two Ceratocystis fimbriata, Bipolaris sorokiniana, Gaeumannomyces graminis, Ceratobasidium cornigerum, Rhizotonia cerealis, Phytophthora parasitica, Phytophthora capsici, Botrytis cinerea, two Rhizoctonia solani, Sclerotinia sclerotiorum and Magnaporthe grisea. The level of suppression of growth 7 days after inoculation varied. Based on growth suppression, the 28 isolates were grouped into three clusters by Fuzzy clustering: Cluster I contains F. proliferatum with 20.5% suppression, Cluster II composed of 15 isolates, Fusarium sp., two V. dahliae, two C. fimbriata, B. sorokiniana, C. cornigerum, two R. solani, R. cerealis, S. sclerotiorum, P. parasitica and M. grisea, with 75.2–100% suppression and Cluster III consisted of 12 isolates; five F. oxysporum, F. solani, F. azysporum, F. moniliforme, F. graminearum, F. verticillioides, G. graminis, P. capsici with 40.7–66.2% suppression. Ceratobasidium fimbriata and V. dahliae were more sensitive to biofumigation than S. sclerotiorum and F. culmorum when different amounts of ground powder were used. One gram of powder could suppress the growth of the former two up to 68.6% and 68.7%, but the growth suppression in the latter two by 12.7% and 24.0%, respectively. These results indicated that the amount of plant tissue to be used should be considered depending on target pathogen species. The swollen root of B. oleracea var. botrytis appeared a better material than the leaf for achieving suppression of growth in pathogenic fungi.

Characterization of α,α-trehalase released in the intestinal lumen by the probiotic Saccharomyces boulardii

Objective. Trehalose intolerance due to α,α-trehalase deficiency has scarcely been studied. The purpose of this study was to measure α,α-trehalase activity in intestinal biopsy samples from 200 consecutive patients over a period of 6 months, and to characterize α,α-trehalase released by the probiotic Saccharomyces boulardii (S. boulardii). Material and methods. Enzyme activities were measured in human and rat intestinal mucosal samples using the micromethod of Messer & Dalqvist. α,α-trehalase from S. boulardii was immunoprecipitated and Western blotted using an IgG purified antibody raised against a 23 amino acid peptide of α,α-trehalase of S. cerevisiae. Results. Among 200 patients, most of whom complained of abdominal symptoms and diarrhoea, 18 (9%) had total α,α-trehalase deficiency (0–12 U/g mucosa) and 39 had partial deficiency (3–12 U/g mucosa). Only 4 patients (2%) presented selective α,α-trehalase deficiency with otherwise normal disaccharidases. Expressed per gram of powder, α,α-trehalase from S. boulardii delivered in vitro an activity 175 times higher than that of human trehalase per gram of intestinal mucosa. Vmax (22±0.43 µmol) and Km (5 mM) were close to that of the human enzyme, whereas Western blot revealed a signal of two subunits of 82 kDa. Finally, treatment of rats with S. boulardii resulted in increases in α,α-trehalase activities of 25 to 45% (p<0.01) in endoluminal fluid and intestinal mucosa compared with in controls. Conclusions. Our data suggest that α,α-trehalase deficiency is more common than is believed and that oral administration of S. boulardii could be beneficial in patients with digestive symptoms caused by trehalose intolerance.

Methods to determine denaturation and aggregation of proteins in low-, medium- and high-heat skim milk powders

Skim milk powders (SMPs) of different heat classifications are used in recombined milks and milk products. These SMPs are broadly classified as low-, medium- and high-heat powders, based on their whey protein nitrogen index (WPNI). The WPNI is a measure of undenatured whey protein nitrogen (WPN) content (expressed as milligrams of WPN per gram of powder). This heat classification, based on the WPNI, gives an indirect indication of the denaturation and aggregation of whey proteins and thus the severity of the heat treatments that were used during the manufacture of milk powders. The severity of heat treatment has an impact on the functional properties of the resultant powders or their suitability for different applications. In the present study, we measured the WPNIs of a range of SMPs using a dye binding method (reference method) and attempted to corre- late these results with the WPNI predicted using Fourier transform near infra-red (FT-NIR) spectra, and with denaturation and aggregation of proteins as analysed using various polyacrylamide gel electrophoresis (PAGE) and capillary electrophoresis (CE) methods. In most cases, FT-NIR spec- troscopy provided a rapid method for predicting the WPNI of milk powders, with good correlation (R 2 = 0.985). The correlation was used to successfully predict the WPNI of a new set of powders, and the method could potentially be used to determine the WPNI routinely using appropriate con- trols. The denaturation and aggregation of native monomeric whey proteins as analysed by PAGE and CE correlated well with the WPNI of the respective SMP samples. Modified one-dimensional sodium dodecyl sulfate (SDS)-PAGE and two-dimensional SDS- and then reduced SDS-PAGE gave an indication of the type and composition of disulfide-linked protein aggregates and showed some interesting differences between possible protein-protein interactions involved in the manufacture of low-, medium- and high-heat SMPs. The low-heat powder (WPNI 6.76 mg WPN·g −1 powder) retained most of the whey proteins in the native state. In contrast, the high-heat powder (WPNI 0.33 mg WPN·g −1 powder) contained a comparatively small proportion of native whey proteins, although some α-lactalbumin was present. The degree of denaturation of β-lactoglobulin appeared to be crucial and could be related to the WPNI. skim milk powders / WPNI / protein denaturation and aggregation / 1D and 2D gel elec- trophoresis / FT-NIR

乳幼児の散剤服用法についての検討―少量の水で練る場合の至適水分量について―

A general method of administering powdered medicines to infants is to add a spoonful of water to the powder to make a paste and then making the paste into small dumpling-sized balls. We investigated the optimal amount of water for making a paste for 35 kinds of powdered medicine which included fine granules, granules and dry syrups. The optimal water amount was expressed as an amount per gram of powder. Approximately 80% of the powders examined in this study required 0.2-0.4 mL of water per gram of powder to make a paste that would form small balls. Optimal water amounts were calculated for amounts of powder ranging between 0.1 and 1.5 grams by proportion and when the calculated amounts of water were added, small dumpling sized balls could be formed. In the same way, we also calculated amounts of water required for powdered mixtures of several medicines for 6 prescriptions often prescribed in our pharmacy from corrected standard volumes for each medicine in the mixture. The amounts of water added on this basis achieved the required paste state for all of the powder mixtures used. These results suggest that the optimal water amount for powdered medicines of various weights can be estimated from standard volumes of water by proportion. Thus, optimal water amounts determined by our method may be useful for the administration of mixed powdered medicines to infants.