As part of the alternative management of Spodoptera frugiperda and for food security, a test of the effectiveness of crushed neem in sorghum cultivation was carried out at the Regional Agricultural Research Center of Sotuba during the rainy season from 2020 to 2022. The objectives were: to identify an effective intervention threshold against Spodoptera frugiperda compatible with the use of crushed neem seeds; to determine an effective spraying frequency of neem seed grind and to determine the effect of neem seed grind on sorghum grain yield. A total randomization design with five treatments in five repetitions was carried out. A significant average reduction in the population of the lowest Spodoptera frugiperda larvae was recorded by 0.00 larva/plant, an average incidence of 5.0948% and an increase in the highest average grain yields of 1703 kg-1ha and of straw of 4410 kg-1ha in the sorghum plots under protection. The use of shredded neem seeds can be recommended for the management of Spodoptera frugiperda in sorghum cultivation in Mali.