Grade Urothelial Carcinoma Of Bladder Research Articles

Prognostic analysis of patients with T1 stage high grade of bladder urothelial carcinoma and glandular differentiation

Objective: To evaluate the recurrence and progression of patients with pT1 high grade urothelial carcinoma of bladder (UCB) and glandular differentiation. Methods: We retrospectively analyzed the clinical and pathological information of 208 patients diagnosed as pT1 high grade urothelial carcinoma in the Fifth Central Hospital of Tianjin from January 2006 to February 2019.Among them, 78 cases were diagnosed as glandular differentiation (UCGD), the other 130 patients without histologic variants were served as control. The UCGD group included 62 male and 16 female, whose median age was 67 years old (range 38-81 years old). The control group contained 105 male and 25 female, whose median age was 66 years old (range 40-82 years old). Kaplan-Meier and Cox proportional hazard regression analyses were used to evaluate the predictors of oncologic outcomes. Results: The disease recurrence rate and progression rate in UCGD group were 65.4% (51/78) and 28.2% (22/78), higher than 38.5%(50/130) and 14.6%(19/130) of control group (P<0.05). The median recurrence time in UCGD group was 41 months while 55 months in the control group. The median progression time in UCGD group was 39 months while 54 months in the control group. According to the univariate analysis, largest tumor size (P=0.030), UCGD (P=0.003) and lymphovascular invasion (LVI) (P=0.032) were associated with disease recurrence. UCGD (P=0.036) and LVI (P=0.011) were associated with progression. Additionally, Cox multivariate analysis revealed that UCGD (P=0.001), LVI (P=0.038) were the independent factors of disease recurrence. UCGD (P=0.007) and LVI (P=0.037) were also found to be the independent factors of disease progression. Conclusions: Patients with T1 stage UCB and UCGD are at higher risk of disease recurrence and progression. Therefore, these patients should be followed up closely after being diagnosed and undergo individual treatment according to the situation.

PD03-03 HOW EFFECTIVE IS MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING VESICAL IMAGING REPORTING AND DATA SYSTEM (VI-RADS) FOR BLADDER CANCER STAGING: CAN IT REPLACE RE STAGING TRANSURETHRAL RESECTION OF BLADDER CANCER IN BLADDER CANCER?

You have accessJournal of UrologyBladder Cancer: Non-invasive I (PD03)1 Apr 2020PD03-03 HOW EFFECTIVE IS MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING VESICAL IMAGING REPORTING AND DATA SYSTEM (VI-RADS) FOR BLADDER CANCER STAGING: CAN IT REPLACE RE STAGING TRANSURETHRAL RESECTION OF BLADDER CANCER IN BLADDER CANCER? Muhammad Abdus Salam*, Sharmin Akther, Faisal Islam, Pranashish Saha, Ibrahim Kaiser, Ghazi Shahinul Islam, Shahed Hossain, and SM Bakhtiar Muhammad Abdus Salam*Muhammad Abdus Salam* More articles by this author , Sharmin AktherSharmin Akther More articles by this author , Faisal IslamFaisal Islam More articles by this author , Pranashish SahaPranashish Saha More articles by this author , Ibrahim KaiserIbrahim Kaiser More articles by this author , Ghazi Shahinul IslamGhazi Shahinul Islam More articles by this author , Shahed HossainShahed Hossain More articles by this author , and SM BakhtiarSM Bakhtiar More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000823.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Multiparametric MRI (mpMRI) is widely used in the imaging of other types of cancers, though its usefulness in Urothelial cancer of bladder has yet to be fully elucidated. We wanted to determine the efficacy of staging accuracy of routine use of mpMRI and VI-RADS (Vesical Imaging-Reporting And Data System) in staging Urothelial bladder cancer. METHODS: This prospective study was undertaken on 62 patients with mpMRI and VI-RADS in staging high grade Urothelial bladder cancer. Primary Transurethral resection of bladder tumor ( TURBT) mpMRI was performed routinely in all cases, from Jan 2018 to July 2019. Of them 36 patients with High grade Urothelial carcinoma of bladder, the specimen did not contain Muscularis Propria requiring a Restaging TURBT. Radical cystectomy was performed in 18 patients during this time frame. The mpMRI staging was correlated with the final pathologic staging. RESULTS: Analysis of our results revealed a highly significant (P<-0.001) mpMRI accuracy of 88% for muscle invasion, 96% accuracy for perivesical fat invasion and 74% accuracy of MRI detection of lymph node metastases. CONCLUSIONS: A larger prospective study is however, required for determining the exact role of MRI in the staging of bladder carcinoma. Source of Funding: No Sponsor © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e72-e73 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Muhammad Abdus Salam* More articles by this author Sharmin Akther More articles by this author Faisal Islam More articles by this author Pranashish Saha More articles by this author Ibrahim Kaiser More articles by this author Ghazi Shahinul Islam More articles by this author Shahed Hossain More articles by this author SM Bakhtiar More articles by this author Expand All Advertisement PDF downloadLoading ...