Autoimmune disorders with a dysfunctional immune system may be severely disabling. To determine the clinical efficacy and safety of F1 matrix natural therapy compared to traditional allopathic therapy using NSAIDs, COX‐2 inhibitors, and other agents for autoimmune disorders including rheumatoid arthritis and osteoarthritis[n=20], gout [n=10], and for certain adenocarcinomas [n=10] we randomly applied the GP Einstein F1 matrix therapy to patients with autoimmune conditions compared with conventional therapy. Previous studies with the GP Einstein matrix described below demonstrated that Integrated Immuno‐ Stimulation Mathematical Function and Matrixes of Sigma (3Σ) Quantum Energy Therapy Model is highly effective in infections, auto‐immune diseases and shrinking tumors.Einstein Mathematical Model of Effective Therapy is presented as follows: ∂ΣIQBET > ∂ΣIQBPDE (1) ∂t1 ∂t2, Where the left side of the equation represents the effectiveness of the Einstein Integrated Immuno‐Stimulation Mathematical Functions and Matrixes of Natural Therapy over time, and the right side of the equation represents traditional synthetic pharmacologic Medical Therapy including potential toxicity and side effects. Results demonstrated marked reduction in pain index and improvement in quality of life in all arthritic, gouty, and fibromyalgia patients who received the Natural Matrix therapy and reduction in tumor mass in adenocarcinoma patients. These results suggest that application of the Einstein Natural F1 matrix therapy is a safe and effective treatment regimen for a broad range of autoimmune and other pathophysiologic states.