HPC is currently driving positive change in the information society. Supercomputer technologies are in great demand in the fight against epidemiological threats, including COVID-19. The article analyzes the use of supercomputer technologies in research projects implemented on the most powerful high-performance systems (supercomputers) topping the TOP500 rating. The considered examples of innovative projects, some of which were awarded the Gordon Bell Prize, demonstrate the capabilities of modern computing science in the paradigm of ensuring the sustainable development of the information society and confronting global crises. Significant events of the current stage of confronting the pandemic threat are revealed: achievements and tasks that need to be addressed in order to successfully overcome the crisis and minimize the consequences of an unfavorable epidemiological situation. The necessity of forming and implementing the concept of the National Strategic Computing Reserve is substantiated.