Good Sign Research Articles

Can the clot meniscus and claw signs predict thrombectomy and clinical outcomes in patients with stroke? A systematic review and meta-analysis

BackgroundThe angiographic shape of an occlusion, like the clot meniscus sign and the claw sign, has been reported to potentially impact the recanalization rate and clinical outcome in patients undergoing...

Genetic architecture of yield and yield contributing traits in chickpea (Cicer arietinum L.)

Genetic architecture of yield and yield contributing characters of five crosses in chickpea were performed by generation mean analysis. Non-significant χ2 values were noted for plant weight at harvest (PWH), number of pods per plant (NPd/P) and number of seeds per plant (NS/P) in cross-2; for number of secondary branches at first flower (NSBFF) and number of secondary branches at maximum flower (NSBMF) in cross-3 and for number of primary branches at maximum flower (NPBMF) in cross-4. Among these, PWH in cross-2; NSBFF and NSBMF in cross-3 and NPBMF in cross-4 were also non-significant regarding C and D scales. Non-significant scale coupled with non-significant χ2 values indicated only additive-dominance relationship for those characters and crosses that would likely be helpful in doing successful breeding plan easily for the development of potential lines in chickpea. Gene effects viz., additive [d], dominance [h], additive × additive [i] and dominance × dominance [l] were significant for different crosses and characters indicating involvement of additive, dominance, additive × additive and dominance × dominance gene interactions in the control of these traits. Most of the studied characters exhibited duplicate type of epistasis therefore, recurrent selection for these traits is suggested. Effective factor (K1) was less than one for all the characters and crosses indicating minimum one group of gene controlled the characters. Both broad (h2b) and narrow (h2n) sense heritability in majority cases were found to be high which indicates that selection for high heritability showing traits is likely to be effective. Mid-parent (MP) and better-parent (BP) heterosis found to be non-significant in maximum cases. All the characters and crosses showed non-significant inbreeding depression (ID) indicating a good sign for further genetic work.

Law on environmental protection in tourist villages in the context of sustainable development of the tourism industry: A qualitative case study in Vietnam

After the Covid-19 pandemic, Vietnam's tourism industry welcomed 1.37 million international visitors. For the whole year 2023, the total number of international visitors will reach 12.6 million, nearly 3.5 times higher than in 2022, exceeding 57% of the original target (8 million) and reaching the adjusted target (12 -13 million views). In Vietnam, which a country which is undergoing economic development, this is a good sign for many workers and businesses, but it can create great pressure on environmental protection in many localities with tourist destinations. For example, as a destination attracting foreign tourists in Hoi A City, Quang Nam Province, Vietnam, the average amount of waste per day is nearly 100 tons; of which single-use plastic waste accounts for 15 - 23% (Thu Huong 2022). In order to prevent and minimize environmental pollution in tourist villages, the Goverment of Vietnam has issued many different documents such as: Decree No. 08/2022/ND-CP orienting no circulation after 2025 and using single-use plastic products and non-biodegradable plastic packaging in tourist areas and destinations; Decision No. 1316/QD-TTg Project to strengthen plastic waste management in Vietnam also points out that by 2025, 100% of tourist resorts and accommodation establishments will not use single-use plastic products and plastic bags which are so hard to decompose. In addition, the Government has also issued a set of criteria guiding environmental protection for tourism establishments and services in tourist areas and destinations, with instructions on minimizing plastic waste...However, around the issue of environmental protection in tourist villages in Vietnam, there are still problems that need to be solved. Through qualitative analysis method, the authors will analyze and propose solutions to remove regulations related to environmental protection mechanisms in tourist villages, aiming at sustainable development of the tourism industry towards a circular economy in the current period.

Sildenafil-inducing allergic angina in elderly with intertwining sinus arrhythmia, wavy triple sign, wavy double sign (Yasser’s signs), and mild covid-infection; interpretation and management

Rationale: Sildenafil is a phosphodiesterase-5 inhibitor (PDE5-I) drug used to treat erectile dysfunction (ED) and pulmonary arterial hypertension. Allergic angina and infarction are broad-spectrum mast cell activation disorders accompanied by acute coronary syndromes (ACS) and are known as Kounis-Zafras (KZ) syndrome. Sinus arrhythmia is a variation of normal sinus rhythm (NSR) that is associated with an irregular rate in which the change in the R-R interval is greater than 0.12 seconds. Wavy triple and Wavy double ECG signs (Yasser’s sign) are new specific diagnostic and therapeutic signs seen in the cases of hypocalcemia. Mild COVID-19 infection means you have symptoms like cough, sore throat, and fatigue, but no dyspnea. Patient concerns: An elderly married male farmer patient was admitted to the intensive care unit with angina, hypotension, generalized hives, Wavy triple, and Wavy double ECG signs after ingestion of sildenafil tablet with mild COVID-19 infection in a previous chronic obstructive pulmonary disease (COPD). Diagnosis: Sildenafil-inducing Kounis syndrome in the elderly with intertwining sinus arrhythmia, Wavy triple sign, Wavy double sign (Yasser’s signs), and mild COVID-19 infection. Interventions: Electrocardiography, oxygenation, IV fluids, and echocardiography. Outcomes: A dramatic clinical and electrocardiographic improvement had happened. Lessons: Sildenafil-inducing Allergic angina and anaphylaxis may be innovative cardiovascular findings. Mild COVID-19 infection, sometimes, can be insignificant. An associated sinus arrhythmia may be a good cardiovascular sign. The dramatic improvement in both clinical and electrocardiographic ST-segment depressions and elevations supports the efficacy of both anti-ischemic and anti-allergic measures.

Shallow-water whale-fall communities: Evidence from the middle–late Eocene basilosaurid whale bones, Wadi El-Hitan, Fayum, Egypt

The present study examines the basilosaurid whale bone specimens collected from the Sandouk El-Borneta section, Wadi El-Hitan (Valley of Whales), Fayum, Egypt. These specimens are embedded in highly fossiliferous calcareous sandstones of the middle Eocene Gehannam and the upper Eocene Birket Qarun formations. These whale bones display some post-mortem alterations, representing good signs of at least three distinct stages in what is called the whale fall. The co-occurrence of shark, ray, and crocodile fossil specimens with the examined whale bones may indicate the first mobile-scavenger stage. Borings of the siboglinid polychaete genus Osedax represent the most common worm type that deeply bioeroded the whale bones, contributing to their rapid degradation, and representing the enrichment-opportunist stage. These fossil traces of the bone-eating worm Osedax represent the first record in the Eocene Epoch regionally and inter-regionally, filling the gap between the Late Cretaceous and the Oligocene occurrences. Subsequently, the studied whale bones served as hard substrates for some calcareous tube-dwelling encrusting polychaetes, balanoid barnacles, sheet‐like cheilostome bryozoans, and scleractinian corals. Furthermore, a bioerosion structure produced by polychaete annelids was also observed. The presence of these sclerobionts assemblage confirms the well-developed final reef stage with prolonged exposure and colonisation of these whale bones prior to final burial. Based on the recorded post-mortem alterations, together with other sedimentological and palaeontological data, the studied whale bones were deposited in a shallow open marine bay to sheltered gulf environments, which were characterised by low depositional energy, low to moderate rate of sedimentation, and high surface water productivity.

The Role of Women in Political Participation in Cambodia: A Case Study of Svay Rieng Province

The government considers women as the backbone of Cambodia's economy and society. Despite a good sign, the female parliamentary representation in Svay Rieng fluctuated in the last three mandates (60% in 2008 and 2013, 80% in 2018, and 60% in 2023). The study aims to investigate the “socioeconomic”, “traditional-cultural”, “family”, and “personal” factors affecting gender roles in political involvement in Svay Rieng province, to assess perceptions and attitudes regarding women's political engagement. A mixed-methods approach was utilized, administering surveys to 119 participants and semi-structured interviews with 8 women actively participating in politics and leadership roles, using snowball sampling. The findings emphasize 1) Family-factors (domestic responsibilities, violence, and lack of support) hinder women's political participation the most, 2) Personal factors: limited education and self-confidence, 3) Socio-economic obstacles (the social devaluation of women, violence against women, limited outreach initiatives, and the impact of economic crises), and 4) Traditional customs, cultural norms including prescribed gender roles further contribute to the challenges faced by women in politics. Despite these obstacles, the study identifies positive perceptions and attitudes towards women's political participation. Participants underlined the need to empower women at both the national and sub-national levels, as well as fostering capacity development and extending possibilities. The recommendations include adopting gender equality legislation, increasing awareness, improving capacity-building programs, providing supportive infrastructure, engaging male allies, promoting cooperation, and assuring long-term commitment. A future study should look at additional elements that may impact women's political engagement, as well as evaluate the efficiency of existing policies for empowering women in Svay Rieng.

Apoptosis inducing anti-proliferative activity of Citrullus lanatus seeds against A549 cell lines

Cancer is a leading dangerous death-causing disease in millions over the world. It arises due to the uncontrolled growth of mal-functioned cells and formed as tumors. The disease can affect any part of the body. Still, it is a quest to find anti-cancer drugs which has been the major research endeavor around the globe. Traditionally humans use plants and their derived products as a source to cure various diseases. In recent years many researches had paved the way to use plant-based drugs. The current research aims to evaluate the anticancer activity of Citrullus lanatus seeds against A549 lung carcinoma epithelial cell lines. The study uses C. lanatus seeds which naturally contains antioxidants and phytochemicals that prevent cancer cell proliferation. The ethanolic seed extract of C. lanatus showed the presence of phytochemicals such as saponins, alkaloids, proteins and flavonoids by preliminary screening. The extract was tested for its anti-inflammatory showing 96.16 % at maximum concentration. The microbial assays also showed good signs of inhibition against the microorganisms by forming a zone of inhibition. The safety and efficacy of the extract were determined by MTT assay for the cytotoxicity using A549 cancer cell lines and non-cancerous cell lines. The IC50 concentration of C. lanatus seed extract showed dosage dependently at 51.73 μg/ml for A549 cell lines. They also resulted in significant induced cell cycle arrest and apoptosis at the G2 phase by inhibiting the A549 cell line proliferation. The present study works on lung carcinoma to find a better procurement in a traditional way that can develop future hope in the pharmaceutical industry.

Micronutrition and diabetes: a new view at prevention and treatment

Worldwide, millions of people suffer from diabetes. Our study aimed to describe the sample’s weight status and the effects of providing individualized micronutrient prescriptions and nutritional counseling to individuals with diabetes. Of the 46 patients (26 women and 20 men) enrolled in this study between 2014 and 2021, 41% had insulin-resistant diabetes and were over the age of 18. In compliance with the World Health Organization guidelines, anthropometric measurements were taken. The impedencemeter was used to measure the visceral fat. Diabetes affected 41% of the patients, with women making up the majority (74%). An impedencemeter’s average measurement of 6 for visceral fat loss was encouraging, and a glycated hemoglobin analysis of diabetics revealed an average loss of 1.6%. A good sign for lowering the therapeutic load is that 16% of diabetic patients were able to stop taking any medication at all, and 79% of patients were able to reduce their dosage. This study served as a strong foundation for the creation of customized nutritional management programs in Morocco to enhance the metabolic health of patients who are obese and insulin-resistant.

PENINGKATAN PENGETAHUAN REMAJA DALAM UPAYA PENCEGAHAN STUNTING MELALUI SOSIALISASI PENCEGAHAN PERNIKAHAN DINI DI DESA TERATAK, BATUKLIANG UTARA

Child marriage is a marriage carried out under the age of 19 years. The early marriage prevention socialization program implemented by the Mataram University Real Work Lecture (KKN) at SMPN 1 Batukliang Utara and SMAN 1 Batukliang Utara, Central Lombok Regency takes the form of counseling on the prevention of early marriage for teenagers. - Adolescents who are still underage are one way to reduce the number of cases of early marriage. With this, the aim of the KKN program can be successful and in line with the target of increasing cases of early marriage in Indonesia in 2018. Based on the results of the questionnaire given before and after the delivery of the material, it was seen that the average increase in students' knowledge from the pretest from 2.4000 and the posttest from 3.3400 to 0.9400. This is a good sign because the education provided is proven to be acceptable and it is hoped that participants can implement this knowledge. Students' knowledge of this is one of the most important factors in efforts to prevent early marriage.

A Study on the Assessment of Knowledge about Basic Life Support among Undergraduate and Post graduate Science Students

Aim: To assess the knowledge about basic life support among undergraduate and post graduate science students. Methods: A prospective observational study was conducted among the students of different colleges with various science courses. A total of 140 study participants were included in the study based on the study criteria. The data was collected using a questionnaire designed with the google form. The questionnaire consists of 20 questions regarding the basic life support. The google form was circulated among the social media groups and the responses recorded were analysed and interpreted. Students of both the genders of age above 18 years studying various science courses were included and students other than the life science courses in various colleges were excluded from the study. Results: A total of 140 study participants were included in this study. Among them, 45 (32.1%) were found to be males and 95 (67.9%) were found to be females. Most of the study participants were in the age group 21-25 years (56.4%). In this study, a total of 20 questions were given in order to assess the knowledge of the students in the aspect of basic life support. Among the 140 study participants, 59 (42.1%) were observed to be with good knowledge, 75 (53.6%) were observed with moderate knowledge and 6 (4.3%) were observed to be with poor knowledge in the aspect of basic life support. Conclusion: In this study, most of the study participants were having moderate knowledge (53.6%) followed by good knowledge (42.1%) in the aspect of basic life support. Almost 95.7% were having ample knowledge in the aspect of dealing the basic life support measures which seems to be very good sign and lack of knowledge in dealing these aspects among the various science background students will definitely impact the society in a negative way. In conclusion, we recommend the training in CPR/BLS should be implemented in the curriculum of all the students itself which will definitely be a valuable life saving skill set to the society.

Improving Household Income by Growing Medicinal Plants in Hoa Binh Province, Vietnam: A Case Study of Celastrus hindsii

The study focused on surveying and evaluating factors affecting the income of households growing medicinal plants in Hoa Binh province, Vietnam. To ensure the sample size, the expected number of samples was 120 to survey medicinal herb growers in Lac Thuy, Luong Son, Yen Thuy districts, and Hoa Binh City (it was expected that 30 samples were to be collected in each district or city). After screening the survey results, the collected data was reduced to 109 samples that met the requirements for providing all necessary survey information for analysis. These are good signs in the transformation of crop structure in Hoa Binh province, Vietnam. Factors affecting mixed income of farmer households growing medicinal plants include fertilizers and pesticide costs, selling prices, infield transportation, and propaganda – incentives. Therefore, necessary solutions in the coming period to improve household income of farmers growing medicinal plants in Hoa Binh province include: (i) Promoting training, propaganda and encouragement for farmers to grow medicinal herbs; (ii) Investing in upgrading the internal transport system in medicinal herb production areas; and (iii) Strengthening linkages in promoting the consumption of medicinal products. Developing the cultivation of medicinal plants is an effective solution for raising household income in Hoa Binh province, Vietnam.

Dielectric properties of low-temperature-grown homoepitaxial (−201) β-Ga2O3 thin film by atmospheric pressure plasma-assisted CVD

The atmospheric pressure plasma-assisted chemical vapor deposition technique has successfully demonstrated unintentionally doped (UID) Ga2O3 growth at 350 °C. This technique allows independent and homogeneous multiple nuclei growth of Ga2O3, leading to three-dimensional grain growth at a rate of ⁓0.17 μm/h. In the study of Schottky barrier diodes, the Schottky-like current (I)–voltage (V) response shows typical behavior on Ga2O3. This is a good sign at an early stage of device development on the grown sample. The extracted barrier height of ⁓2.20 eV was higher, which may be due to unintentional PtOx formation on the Ga2O3 surface. Furthermore, the extracted capacitance (C)–voltage (V) depth profiling of the effective impurity concentration was nearly flat, ⁓1.5 × 1017 cm−3, in the unintentionally doped grown film. The effective impurity concentration is comparable to the UID carrier concentration of epitaxial films fabricated using the high temperature growth technique. Therefore, low-temperature-grown homoepitaxial Ga2O3 thin films grown by atmospheric pressure-plasma-assisted chemical vapor deposition can be used in future Ga2O3-based power device applications.

Activities of clinical pharmacologists across Europe: A survey by the European association of clinical pharmacology and therapeutics.

In order to explore clinical pharmacology and therapeutics (CPT) teaching and practices across continental Europe, the European Association of Clinical Pharmacology and Therapeutics (EACPT) made a survey in 2022 amongst its 27 affiliated societies. The survey was made available online to EACPT representatives, and 47 filled-in questionnaires were received from 25 countries (one to five per country), representing all geographic areas of Europe. Clinical pharmacologists (CPs) spend 25%, 30%, 15%, and 25% of their time in teaching, hospital activities, committees, and research, respectively, with large variations across and within countries. CPT courses are given at Schools of Medicine in all the countries except one, mostly organized and taught by medical doctors (MDs). In Central, Western, and Southern Europe, the teachers may have medicine or pharmacy training. Therapeutic drug monitoring and pharmacovigilance were the hospital activities most frequently reported, and clinical/forensic toxicology, rounds of visits, and pharmacogenetics the least. Two-thirds of the panel think CPs should be MDs. However, the transversal nature of CPT was underlined, with patients/diseases and drugs as gravity centres, thus calling for the complementary skills of MDs and PharmDs. Besides, most respondents reported that clinical pharmacists in their country are involved in rounds of visits, pharmacovigilance, TDM, and/or pharmacogenetic testing and that collaborations with them would be beneficial. CPT comes with a plurality of backgrounds and activities, all required to embrace the different pathologies and the whole lifecycle of medicinal products, but all of them being rarely performed in any given country. The willingness to use common CPT teaching material and prescribing exams at the European level is a good sign of increasing harmonisation of our discipline Europewide.

Comparison of Compressive Strength of Concrete Produced with Different Types of Fine Aggregates

The most often used building material worldwide is concrete. It is made by mixing water, coarse aggregate, binding ingredients, and fine aggregate in the right amounts. Because it provides a good sign of the general quality of the concrete and is very simple to test, particularly under uniaxial compression, concrete strength is a commonly examined attribute. Concrete’s compressive strength serves as the primary criterion for structural designs, and fine aggregate has a significant impact on compressive strength as well. The three samples used for this research—quarry dust, erosion-deposited sand, and borrow pit sand—were subjected to sieve analysis in order to compare the compressive strengths of concrete made with various types of fine aggregate. 36 cubes, twelve for each sample in the mix ratio of 1:2:4, were cast. The samples underwent a compressive strength test after curing for 7, 14, 21, and 28 days by complete submersion in water. With compressive strengths of 9.93N/mm2 for quarry dust sand, 9.03N/mm2 for borrow pit sand and 8.0N/mm2 for erosion deposited sand respectively, the concrete made with quarry dust had the maximum compressive strength, followed by that made with borrow pit sand and erosion-deposited sand. It is recommended that quarry dust is considered suitable out of the samples tested for concrete production based on this research findings.

Distinct correlation network of clinical characteristics in suicide attempters having adolescent major depressive disorder with non-suicidal self-injury

Suicidal behavior and non-suicidal self-injury (NSSI) are common in adolescent patients with major depressive disorder (MDD). Thus, delineating the unique characteristics of suicide attempters having adolescent MDD with NSSI is important for suicide prediction in the clinical setting. Here, we performed psychological and biochemical assessments of 130 youths having MDD with NSSI. Participants were divided into two groups according to the presence/absence of suicide attempts (SAs). Our results demonstrated that the age of suicide attempters is lower than that of non-attempters in participants having adolescent MDD with NSSI; suicide attempters had higher Barratt Impulsiveness Scale (BIS-11) impulsivity scores and lower serum CRP and cortisol levels than those having MDD with NSSI alone, suggesting levels of cortisol and CRP were inversely correlated with SAs in patients with adolescent MDD with NSSI. Furthermore, multivariate regression analysis revealed that NSSI frequency in the last month and CRP levels were suicidal ideation predictors in adolescent MDD with NSSI, which may indicate that the increased frequency of NSSI behavior is a potential risk factor for suicide. Additionally, we explored the correlation between psychological and blood biochemical indicators to distinguish suicide attempters among participants having adolescent MDD with NSSI and identified a unique correlation network that could serve as a marker for suicide attempters. Our research data further suggested a complex correlation between the psychological and behavioral indicators of impulsivity and anger. Therefore, our study findings may provide clues to identify good clinical warning signs for SA in patients with adolescent MDD with NSSI.

ANALISIS METODE THAWAB WA ‘IQOB DALAM PEMBELAJARAN BAHASA ARAB: PERSPEKTIF HADIST NABI SAW

This study aims to comprehensively determine the thawab wa iqob method in learning Arabic: The perspective of the hadith of the Prophet SAW. This research is a library research, where the data comes from written materials such as books, journals and so on. In collecting data, the author uses data obtained by using the documentation method taken from learning method books, Arabic learning books, Islamic education books and other supporting books. The results of the study show that the thawab method in learning Arabic is in the form of praise, as exemplified by the Prophet when he gave praise to Abu Hurairah who was enthusiastic about asking and collecting hadiths from the Prophet. In learning Arabic, teachers can apply the thawab method in the form of praise when they see good and commendable signs made by students so that when given praise, students can be more motivated and enthusiastic in the learning process. The Iqob method in learning Arabic from a hadith perspective, namely, in the form of a reprimand, the Prophet once reprimanded a friend who made a mistake in front of other friends in a gentle way so that he would not feel offended and feel ashamed. In learning Arabic, teachers can apply verbal punishment in the form of reprimands to students who commit violations or mistakes as exemplified by the Prophet, so that students are aware and do not repeat their mistakes.

JINGLE BELLS IN THE HISTORICAL WAYS OF CAROL SONGS

Carols traditionally held a central place in the celebration of the Christmas season. It is believed that the angels sang the first carol on the day of Jesus' birth on the first Christmas night. But Carols before the birth of Jesus come to our attention as we travel through history. The beginning of the carol is detailed in history as it was part of the Winter Solstice celebration. There was also a time when carols were written and sung for all four seasons. May carols, Harvest carols etc. were celebrated. Thus in the beginning, Christmas carols were more secular rather than sacred and religious. The secularization didn’t destroy the significance of this carols, it only took the celebration back to its roots and reminded us of the social significance of early secular carols. However, it is a fact that the tradition of singing carols at Christmas only continued later. Many carols today have little to do with Christmas. Are they good signs that carols are becoming secular like in the early days? In the world of music, many songs have been composed about Sacrifice, Love and Peace. How Christmas carols have lasted so long, remaining in people’s minds for centuries and millennia? A study in search of the roots of the Christmas Carols is intended here. An attempt has also been made to associate the immortal Christmas Carols to the centuries in which they were born.

Canine idiopathic generalized tremor syndrome, immune-mediated?

Idiopathic generalized tremor syndrome is a disorder characterized by an acute onset of full-body tremors, sometimes accompanied by vestibulo-cerebellar signs, that is responsive to treatment with corticosteroids. Although considered to have an overall good outcome, relapsing and persistent mild clinical signs have been described. So far, little is known about the etiopathology of this syndrome, but it is believed to have an immune-mediated origin. In human medicine, description of numerous autoantibodies involved in certain non-infectious neurologic disorders has revolutionized understanding of their pathophysiology, diagnosis and treatment. In this multicenter retrospective study, we aimed to describe the clinical signs, course, and outcome of dogs with idiopathic generalized tremor syndrome and correlate potential findings with the presence or absence of autoantibodies associated with autoimmune cerebellar syndromes in humans. Information regarding signalment, history, clinical signs, laboratory findings, diagnostic imaging and testing for regional infectious diseases was gathered and the remaining serum and CSF samples were then analyzed for neural antibodies against targets associated with autoimmune encephalitic diseases of humans. Thirty-three dogs were included, and screening for neural antibodies was performed in 30 of those dogs. The analysis showed an increased titer of mGluR1 antibodies in two dogs, GFAP and later in the course of disease mGluR1 antibodies in one dog and an increase in unspecific autoantibodies which could not be further classified in two dogs. Dogs with detectable neural autoantibodies always had cerebrospinal fluid abnormalities in the form of a pleocytosis, with or without increased protein concentration, and tended to present with hyperthermia, potentially indicating a more severe clinical form of idiopathic generalized tremor syndrome in these cases. In conclusion, idiopathic generalized tremor syndrome is proposed to be an immune-mediated disorder potentially mediated by neural autoantibodies in a subgroup of dogs.

Lung Parenchymal Damage Due to High Voltage Electric Shock

In electric shocks, lung tissue is a poor conductor and has low resistance. Therefore, they are not very sensitive to the development of tissue damage due to electric current. In this study, we wanted to present a rare case of lung parenchymal burn as a result of electric shock. A 21-year-old male patient was brought to the emergency department by ambulance after being electrocuted with a current of 15,000 volts after contact with a high voltage line while working with a construction machine. The general condition of the patient was good and vital signs were stable. However, his pulse oxygen value was 74 and his breathing was slightly tachypneic. There were no lesions in the chest and abdomen due to electrical burns. Radiologic imaging showed bilateral diffuse tissue damage in the lung tissue. The patient was referred to a tertiary care institution with an intensive care burn unit. In traumas caused by high-voltage electric shock, burns on the body surface may be insufficient to determine the severity of the trauma. A multidisciplinary approach must be provided to these patients.

Association between Serum Klotho and All-Cause Mortality in Chronic Kidney Disease: Evidence from a Prospective Cohort Study

Plain Language SummaryChronic kidney disease (CKD) is a serious health condition where your kidneys do not work as they should. People with CKD face a higher risk of illness and even death. We wanted to know if a substance called Klotho in your blood might be connected to how long people with CKD live. We studied information from over 2,400 CKD patients. We followed them for almost 7 years to see what happened. We found that people with higher Klotho levels in their blood tend to live longer. It is like a good sign for their health. But we also discovered something interesting. The relationship between Klotho and survival is not simple. It is shaped like the letter “L.” Up to a certain point, higher Klotho levels mean a better chance of living longer. But after a certain level, having even more Klotho does not seem to make a difference. So, it is not just about having lots of Klotho; but about having the right amount. Our study helps us understand Klotho better and its connection to CKD. Knowing more about Klotho could help doctors find new ways to help people with CKD live longer and healthier lives. In plain words, having enough Klotho in your blood might be good for your health if you have CKD. But having too much does not seem to help any more than having just enough. This information could help doctors find better ways to treat people with CKD.