Association between Serum Klotho and All-Cause Mortality in Chronic Kidney Disease: Evidence from a Prospective Cohort Study

Abstract

Plain Language SummaryChronic kidney disease (CKD) is a serious health condition where your kidneys do not work as they should. People with CKD face a higher risk of illness and even death. We wanted to know if a substance called Klotho in your blood might be connected to how long people with CKD live. We studied information from over 2,400 CKD patients. We followed them for almost 7 years to see what happened. We found that people with higher Klotho levels in their blood tend to live longer. It is like a good sign for their health. But we also discovered something interesting. The relationship between Klotho and survival is not simple. It is shaped like the letter “L.” Up to a certain point, higher Klotho levels mean a better chance of living longer. But after a certain level, having even more Klotho does not seem to make a difference. So, it is not just about having lots of Klotho; but about having the right amount. Our study helps us understand Klotho better and its connection to CKD. Knowing more about Klotho could help doctors find new ways to help people with CKD live longer and healthier lives. In plain words, having enough Klotho in your blood might be good for your health if you have CKD. But having too much does not seem to help any more than having just enough. This information could help doctors find better ways to treat people with CKD.