Good Medicine Research Articles

A005: Progress in Sports Rehabilitation for Adolescent Idiopathic Scoliosis

Background: Adolescent idiopathic scoliosis has become the third leading "killer" of the health of Chinese adolescents, following obesity and myopia. Scoliosis is a three-dimensional deformity of the spine, usually characterized by a lateral curvature of the spine accompanied by rotation. The diagnostic criterion is a Cobb angle greater than 10 degrees on X-ray. With the promotion of the concept of "exercise is good medicine" and the Healthy China strategy, exercise therapy has received attention and development. Purpose: To summarize different sports rehabilitation methods for adolescents with idiopathic scoliosis worldwide with the hope to raise awareness of adolescent idiopathic scoliosis and explore sports rehabilitation methods. This will facilitate physical therapists in incorporating effective methods into their practice to improve the new sports rehabilitation methods for adolescents with idiopathic scoliosis. Methods: Comparative analysis of current exercise rehabilitation methods for scoliosis using literature review and logical analysis. Results: The main sports rehabilitation treatment for idiopathic scoliosis in China is the traditional rehabilitation treatment of Chinese medicine (including Chinese massage, Chinese bone-setting technique, and traditional health exercises), the scoliosis specific exercise therapy recognized by the SOSORT (Germany Schroth therapy, Spain BSPTS therapy, Poland DoboMed therapy, UK Side shift therapy, France Lyon therapy, Italy SEAS therapy, Poland FITS therapy); There are also methods that are not classified but play a positive role in the treatment of scoliosis, such as yoga, traction therapy, core stability training and other exercise therapy methods. Different exercise therapies have their own advantages and disadvantages and indications in the treatment of scoliosis. It is probable that exercise therapy has positive effects on the treatment of adolescent idiopathic scoliosis. Conclusion: Although currently there are multiple sports rehabilitation methods, no single exercise can completely correct scoliosis. At present, multiple exercise therapy is used in the clinical treatment of scoliosis, but there’s insufficient medical evidence for the correlation, principle and efficacy of the method. In the future, with the development of sports medicine and technological advancements, exercise therapy may be more widely applied in the treatment of scoliosis, aiming to improve the rehabilitation effect and patient quality of life. It is necessary for relevant scientific research institutions and personnel to increase the research investment and innovation of relevant treatment methods, and more studies are needed to further explore the mechanism of effect of exercise.

Edukasi DAGUSIBU (Dapatkan, Gunakan, Simpan, Buang) Obat pada Ibu Rumah Tangga di Desa Pematang Johar

In society in general there is still a lot of inappropriate use of drugs. Providing educational information will increase public knowledge and increase their understanding. In this case, Al-Wasliyah Muslim Nusantara University students provided education about DAGUSIBU (Get, Use, Store and Dispose of) medicines correctly to housewives in Pematang Johar Village. Counseling is carried out on how to manage medicines properly so that it can increase public knowledge, especially housewives. This outreach activity for housewives begins with identifying the problems experienced by the community, which is done by approaching the community in Pematang Johar village and conducting interviews to gain information about their knowledge regarding the correct use of medicines using Powerpoint and projector media. The material presented in the counseling includes the 4 Right and 1 W aspects, namely Right Indication, Right Dosage, Right Patient Condition, Right Use and Beware of Side Effects of Drugs. This will increase housewives' knowledge of good and correct DAGUSIBU medicine.

Educational Case Study of the Total Plate Count of Jamu Gendong in Cirebon City

Indonesian herbal heritage that still survives and continues to be preserved. Jamu that is very well known by the people of Indonesia is jamu gendong. Based on the Regulation of the Head of the Food and Drug Administration of the Republic of Indonesia number 12 of 2014 concerning traditional medicines that are prohibited from circulating, namely traditional medicines that do not meet the quality safety and usefulness requirements, one of which meets the TPC test requirements. The Total Plate Count (TPC) test is used to calculate the number of bacteria that grow and develop in a sample, as well as a reference for determining the quality and safety of simplisia. One of the regulations of the Food and Drug Supervisory Agency (BPOM) no 32 of 2019 concerning the safety and quality requirements of traditional medicines that in the process of making liquid preparations of internal medicine must meet the requirements of a total plate number value of r < 105 colonies / mL. The purpose of this study was to determine the TPC value before and after How to Make Good Fresh Herbal Medicine (CPJB) education and to determine the effect of CPJB education on jamu gendong rice kencur sellers in Kejaksan District and Kesambi District. Samples in this study were taken from 5 herbal medicine sellers. The results of this study showed the TPC value before CPJB education, sample 1 12 x 10-5, sample 2 1.4 x 10-4, sample 3 2.6 x 10-4, sample 4 3.6 x 10-4, sample 5 2.2 x 10-4. This study used leaflet media to conduct CPJB education. TPC value after CPJB education, in sample 1 amounted to 2.7 x 10-4. The conclusion of this study is that there is an effect of CPJB education on kencur rice herbal sellers, as evidenced by changes in TPC values before education and after education.

Huangjing is not only a good medicine but also an affordable healthy diet.

Huangjing is not only a good medicine but also an affordable healthy diet.

“Good medicine is bitter” or “drinking poison to quench thirst”? The impact of maturity mismatch on corporate ESG performance

The maturity mismatch can influence corporate behavior to some extent, so whether they affect corporate ESG performance becomes an issue worthy of attention. This paper verifies maturity mismatch's negative effect on corporate ESG performance. This inhibitory effect acts through governance performance and productive efficiency. Furthermore, the negative impact of maturity mismatch on corporate ESG performance varies heterogeneously with different ownership and financing constraints.

Cardioprotective and antispasmodic effects of Humulus lupulus (Hops) in an oral subacute treatment in rats

Hops (Humulus lupulus) was used to treat menopausal symptoms because it contains phytoestrogens. Since these compounds prevent cardiac ischemic diseases, it was evaluated whether oral administration of an ethanol extract (Hops-T) to rats during a week could reduce cardiac post-ischemic dysfunction. Moreover, its effects on visceral peristaltism and the mechanisms of action were studied. Rat isolated hearts were perfused inside a calorimeter, left intraventricular pressure and calorimetrical signals were recorded during ischemia/reperfusion. The NO-synthases and mKATP channels roles were evaluated by respectively blocking them with L-NAME and 5-HD before ischemia. After the experiment, western-blots for cellular pathways (p-AKT, p-PKCϵ, GSK3b and BCL-2) were done. In isolated intestinal, bladder and uterine rat tissues, contractile carbachol concentration-response curves (CCh-CRCs) were performed. The HPLC-DAD mainly showed prenylated flavonoids, beta acids and isoflavones. Hops-T increased contractile and energetic recoveries more significantly in the male rat hearts compared to females, due to beneficial NO production and mitochondrial mKATP channels activation. However, the p-AKT, p-PKCϵ, GSK3b or BCL-2 expressions were not affected after reperfusion. Hops-T inhibited CCh-CRCs in intestinal, bladder and uterine tissues through a non-competitive mechanism. Additionally, it showed a non-competitive antagonism of the Ca2+-CRCs in bladder tissues, similar to the effects observed with verapamil. In conclusion, oral Hops-T prevented cardiac mitochondrial and contractile ischemic dysfunction, and it was a good visceral antispasmodic medicine by interfering with Ca2+ influx. This is a significant finding since it pre-clinically supports the use of hops extract for prevention of visceral spasms and cardiac diseases associated with coronary insufficiency.

Roots and Relations: Celebrating Good Medicine in Indigenous Evaluation

Roots and Relations: Celebrating Good Medicine in Indigenous Evaluation

Phytochemical profile and antimicrobial, anti-inflammatory, antioxidant activities of the essential oils in the aerial part and root of Glehnia littoralis Fr. Schmidt ex Miq

The root of Glehnia littoralis is used as a good traditional Chinese medicine. The aerial part of G. littoralis is often discarded as waste in China, although it is very abundant, which results in waste of resources. In order to utilize the resources, the essential oils of the aerial part and root were isolated from G. littoralis, separately named as GLA and GLR. Their phytochemical profile, antimicrobial, anti-inflammatory and antioxidant effects were investigated. The results showed that the concentrations of GLA and GLR were separately 0.933 g/kg and 1.365 g/kg, and nineteen components were identified from both oils. Among them, panaxynol was the common component with a content of 38.21 % in GLA and 74.02 % in GLR. GLA potently inhibited F. solani and F. incarnatum, GLR strongly suppressed S. albus. GLA and GLR reduced the production of NO, IL-1β, IL‐6, TNF-α in LPS-stimulated RAW 264.7 macrophages. This study provided a theoretical basis for the utilization of the aboveground parts of G. littoralis.

Can Fintech mitigate business risks?--Evidence from the Chinese market

Fintech is an important supplement to the traditional financial system, and its development is a good medicine to alleviate the financing constraints and business risks of enterprises. Based on the data of listed enterprises from 2004 to 2021, this paper adopts the method of panel linear regression to explore the impact of the level of Fintech development on the operating difficulties of local enterprises. The results show that increasing the level of Fintech development can effectively reduce the business risks faced by enterprises, and the conclusion still holds after a series of robustness tests such as adding control variables, replacing explanatory variables, multiple fixed effects, and changing the time interval. The mechanism analysis shows that the level of Fintech will affect the business risk of enterprises by changing the book-to-market ratio, and the heterogeneity analysis shows that the impact of Fintech on the business risk of private enterprises as well as non-Big 4 audited enterprises is more significant. The policy implication of this paper is that the government should actively guide, support and regulate the development of Fintech in different regions to provide policy support and guarantee for enterprises to reduce their business risks. However, attention should also be paid to balancing the relationship between innovation and risk management, data security and privacy protection to ensure the sustainable development of Fintech.

Advances in Quality Control Methods for Colla Corii Asini Preparations

There are numerous records of Colla Corii Asini from ancient times, which is a good medicine for nourishing yin and moistening dryness, tonifying blood and stopping bleeding. Colla Corii Asini and its preparations are composed of proteins and peptides produced by hydrolysis, amino acids and nucleic acids, polysaccharides, trace elements and other components. The market demand for Colla Corii Asini products has been increasing year by year. This, coupled with natural constraints and the downturn in the donkey farming industry, has led to a shortage in the supply of donkey hides, the raw material for Colla Corii Asini. In order to improve the overall quality and evaluation standards of Colla Corii Asini on the market, it becomes particularly important to study the progress of quality control methods for Colla Corii Asini preparations.

Irregular warfare must combine good medicine, with both good tactics and good strategies: Position paper by the French Special Operations Forces Medical Command.

Military operations are no longer limited to the application of counterterrorism and counterinsurgency strategies; they are now characterized by hybrid, irregular, and unconventional features. While some authors have indicated the need for medical support to adapt to these new modes of military operations, they have focused mainly on the tactical level of care on the battlefield. As Sun Tzu states, "Strategy without tactics is the slowest route to victory. Tactics without strategy is the noise before defeat," further proposals are still needed on the application of both medical tactics and medical strategies in irregular warfare. Medical experts from the French Special Operations Forces (SOF) Medical Command have identified specific medical challenges that special operations face in the context of the current transformation of armed confrontations into irregular warfare. This position paper presents original tactical medical proposals for improving medical support in irregular warfare, ranging from the definition of a Primary-Alternate-Contingency-Emergency medical plan to the promotion of telemedical support. Original strategic medical proposals have highlighted the importance of recognizing medical issues in irregular warfare, including the medical actions carried out through and with local partners and the multiple approaches to countering medical threats. The SOF medical community must be closely involved with and facilitate the responses to the shift to irregular warfare. International collaboration and interoperability are more necessary than ever, as they will enable a more effective combination of good medicine with both good tactics and good strategies. These perspectives can also be extended to improve medical care in the conventional armed forces and austere civilian settings. Therapeutic/Care Management; Level V.

Randomised Controlled Trial on the efficacy of Mamajjaka (Enicostemma littorale Linn.) in the Management of Madhumeha (Diabetes Mellitus)

Diabetes Mellitus is in top ten list of diseases causing mortality. In the year 2011, estimated 366 million people were found to be suffering from diabetes mellitus. By year 2030 this morbidity data will rise to approximately 552 million people worldwide. India is having the largest number of diabetics in the world and gets the name ‘Diabetic capital’. This study was carried out with an aim:-‘To Conduct a Randomised Controlled (Upashayatmaka) Trial on the role of Mamajjaka capsule in the management of Madhumeha (DM type-2)’. In this study total 110 patients of Diabetes were selected from NIA hospital and randomly divided into two groups. Group A (Control group) comprise 54 patients were administered with Tab. Metformin and dose was 500mg tablet 1 BD before meals as advised according to allopathic consultant. Group B (Trial group) comprise 56 patients were administered with Cap. Mamajjaka, dose: 500 mg Capsule 2 BD, before 30 min. of meal with lukewarm water. Total duration trial was 100 days. Results obtained in subjective and objective parameters were analysed for the statistical significance by adapting paired T test and unpaired T test. The study revealed that Group-B was found to be more effective in bringing symptomatic relief and Group-A was found to be more effective in improving biochemical markers in the patients of Madhumeha. Cap. Mamajjaka (Enicostemma littorale Linn.) provided better results, suggests that this can be a good complimentary medicine for the patients who are not getting good relief from modern medicine alone.

Physicochemical and heavy metal analysis of Yavani-Sadav Churan – An Ayurvedic formulation

Ayurveda is the most ancient documented healing heritage of the world that describes health management through natural products. Bhaishjya Kalpana, a branch of Ayurveda, describes details of pharmaceutical preparations of different dosage forms. Chooran kalpana is one of the solid dosage forms considered the secondary Kalpana of Kalka kalpana. In a common language, it is known as powder medicine and is used extensively in Ayurvedic treatment. For promoting Ayurveda, traditional health management introduced the term Drug standardization in the manufacturing of Ayurvedic medicine to ensure good quality medicines for the satisfaction of customers in the international market. Drug standardization is the core issue not only for Bhaishjya Kalpana but also for the entire Ayurveda health care. In the present study, Yavani–Sadav Churan was prepared and the physicochemical and Heavy metal analysis of churan is the main aim of the study. In this study, different parameters for assessment of purity, quality, and safety of Yavanisadava chooran will be carried out like organoleptic characteristics, loss on drying, total ash, acid insoluble ash, water-soluble extractives, and Alcohol soluble extractives. pH, Bulk density, Tap density, Particle size, TLC and Heavy metal analysis by AAS method etc., which contribute to a great extent for standardization.

A good medicine tastes bitter: Environmental regulation that shapes China's green productivity

This study scrutinizes the effect of the Sewage Charges System (SCS) reform on the green total factor productivity (GTFP) across China's provinces. Employing the global Luenberger productivity indicator based on a non-radial directional distance function, we observe an upward trend in China's GTFP during the study period. However, the SCS reform precipitates a contraction in the GTFP, particularly pronounced in low-income and resource-based provinces of China. Empirical findings withstand a battery of robustness checks of self-selection and placebo tests. Further mechanistic tests suggest that the SCS reform influences the GTFP by escalating pollution treatment costs, curtailing R&D investment, and undermining the quality of green innovation via crowding-out effects. Overall, the SCS reform is effective in curbing SO2 emissions, but it reduces economic efficiency. Therefore, how to synergize emission reduction and economic growth is an important issue to be addressed in the area of environmental policy design in China.

True glimpses of Southern Sub-Continents of the India

India is an Integral part of the Asian continent and it is the second largest country in this. Bharath is acknowledges world -wide for its unique peculiarities amalgamated with Tasty food, Good medicine, vast culture, noble literature, Marvelous Building Architecture Adventure. Southern States here are advanced developed fully equipped with sophisticated Technology. People lived in the six regions including Telangana, Andhra Pradesh, Karnataka, Tamilnadu, Kerala and Union Territory Puddichhery, Culture, Tradition, festivals and rituals enjoyed commonly. Languages spoken Telugu, Tamil, Tulu, Malayalam. Religious harmony co- existed as Hindu, Islam, and Christianity etc. Precisely know as Dravidians.

The ADEM project: implementation of ‘Good medicines use conversation’ for COPD-patients, embedded in multidisciplinary context.

COPD is a chronic, progressive disease, for which a multidisciplinary approach is crucial. Appropriate follow-up is crucial to improve the quality of life of COPD-patients and reduce associated healthcare costs. 
 A ‘Good medicines use conversation’ COPD is a pharmaceutical care intervention, conducted by the community pharmacist, consisting of a tailored-made education of the COPD-patient on the disease and its treatment. Scientific research (PHARMACOP-trial) has shown that this intervention significantly improves therapy adherence and inhalation technique and reduces exacerbation rates and associated hospitalizations. 
 The aim of the ADEM implementation project was to investigate the needs for a sustainable implementation of this intervention.
 The ADEM project was conducted in Flemish-Brabant (Belgium), with the integrated care region ‘Leuven Cares’ as a separate entity. 
 All participating pharmacies (9 in region Flemish-Brabant and 8 in region ‘Leuven Cares’) received a support package consisting of: 1) a three-part online training about COPD and a visual COPD-atlas; 2) a population management-tool (a query to identify COPD-patients in the pharmacy, resulting in a list of COPD-patients with a ‘score’ per patient as an initial proxy for patient prioritization); and 3) local interdisciplinary meetings (LIM) to discuss and promote the intervention. Pharmacist of the region Caring Leuven additionally received individual care plans, providing an overview of the healthcare status of each COPD-patient, and an individual coaching session.
 Semi-structured interviews were conducted with 8 participating pharmacists (4 region Flemish-Brabant, 4 region ‘Leuven Cares’). Thematic analysis was performed.
 
 All elements of the support package were positively evaluated by the participating pharmacists. The population management tool seemed to support pharmacists in planning, interpreting and prioritizing care for COPD-patients. A follow-up study is needed to further investigate the tool and to what extent population management contributes to a more qualitative and effective pharmaceutical care. 
 COVID-19, lack of personnel, lack of reimbursement and lack of time were identified as limiting factors for the implementation of the protocol-based COPD-intervention. Cooperation with the GP was indicated by the majority as minimal and insufficient. Therefore, LIM’s were evaluated as very important to inform GP’s about the pharmaceutical intervention and make local agreements about the multidisciplinary approach of COPD.
 The findings of this study are in line with the available evidence on the implementation of new services in pharmacies. Many pharmacists have the intrinsic motivation to offer extended pharmaceutical care, but current practices often do not allow this. Population management appeared to be a major factor that can be used to facilitate the implementation. By considering the needs of the local population, pharmacists can work in a more targeted way and prioritize the pharmaceutical services they offer. Given the group of chronically ill people in Belgium is expected to grow in the coming years due to the increasing ageing of the population, there will be an increasing demand for specialized interventions and advice from the pharmacist. It is therefore necessary to provide a sufficient framework for these services, bearing in mind the needs of the local population and the requirement for a pragmatic approach in the pharmacy. 

Good Medicine Does Not Compensate for Bad Surgery.

Good Medicine Does Not Compensate for Bad Surgery.

A Cheerful Heart is a Good Medicine

A Cheerful Heart is a Good Medicine

Analisis Pengelolaan Obat dan Strategi Perbaikan dengan Metode Hanlon di Instalasi Farmasi

This research aims to analyze drug management at the Purwokerto Dadi Keluarga Pharmacy Installation using efficiency indicators and implementing improvement strategies using the Hanlon method. The method used is a descriptive design for 2018 data which is retrospective and concurrent. Data was collected in the form of quantitative and qualitative data from document observations and interviews with relevant IFRS officers. The research results show that the drug management system at RSDK Purwokerto does not meet standards. From the results of this research, it is necessary to carry out a priority analysis of strategic plans for improving drug management using the Hanlon method, the results are in accordance with the priority scale order as follows; Minimize dead stock of medicines by carrying out good medicine planning so that medicines experience transactions. By re-evaluating the selection of drugs with prescriptions outside the National Forum by considering drugs that rarely have cases of disease/rarely used, re-evaluating at the selection stage, for the quantity needed and type of drug procurement, carrying out drug planning ( RKO) in the management information system, coordinating to avoid polypharmacy, proposing an increase in the drug procurement budget to the drug procurement section, proposing an increase in drug budget costs to the hospital. In conclusion, the current drug management system does not meet standards, the implementation of improvement strategies using the Hanlon method aims to improve and improve drug management efficiency at the Purwokerto Dadi Keluarga Pharmacy Installation.
 
 Keywords: Efficiency Indicators, Pharmaceutical Installation, Drug Management, Hanlon Method.

Pengolahan Tumbuhan Obat Menjadi Obat Tradisional Pada Masyarakat Desa Penyambaran Kecamatan Karang Intan Kabupaten Banjar

The use of traditional medicine by the community is generally only in the form of a decoction, this method is considered less effective and practical because the heating temperature is not controlled which can cause damage to the compounds in the plant. The service was conducted to increase the interest and skills of the community in Penyambaran Village, Karang Intan Subdistrict, Banjar Regency, South Kalimantan Province on processing techniques and how to make good traditional medicine. The results showed an increase in community understanding with an average Post-test of 89.583 compared to an average Pre-test of 45.833. This shows that socialization has been able to increase community interest and understanding related to plants that can be used as traditional medicine, processing, packaging, storage, and drug registration.