Good Characteristics Research Articles

Fermentation Profile, Bacterial Community Structure, Co-Occurrence Networks, and Their Predicted Functionality and Pathogenic Risk in High-Moisture Italian Ryegrass Silage

This study aimed to assess the fermentation characteristics, bacterial community structure, co-occurrence networks, and their predicted functionality and pathogenic risk in high-moisture Italian ryegrass (IR; Lolium multiflorum Lam.) silage. The IR harvested at heading stage (208 g dry matter (DM)/kg fresh weight) was spontaneously ensiled in plastic silos (10 L scale). Triplicated silos were opened after 1, 3, 7, 15, 30, and 60 days of fermentation, respectively. The bacterial community structure on days 3 and 60 were investigated using high-throughput sequencing technology, and 16S rRNA-gene predicted functionality and phenotypes were determined by PICRUSt2 and BugBase tools, respectively. After 60 days, the IR silage exhibited good ensiling characteristics indicated by large amounts of acetic acid (~58.7 g/kg DM) and lactic acid (~91.5 g/kg DM), relatively low pH (~4.20), acceptable levels of ammonia nitrogen (~87.0 g/kg total nitrogen), and trace amounts of butyric acid (~1.59 g/kg DM). Psychrobacter was prevalent in fresh IR, and Lactobacillus became the most predominant genus after 3 and 60 days. The ensilage process reduced the complexity of the bacterial community networks in IR silage. The bacterial functional pathways in fresh and ensilaged IR are primarily characterized by the metabolism of carbohydrate and amino acid. The pyruvate kinase and 1-phosphofructokinase were critical in promoting lactic acid fermentation. A greater (p < 0.01) abundance of the “potentially pathogenic” label was noticed in the bacterial communities of ensiled IR than fresh IR. Altogether, the findings indicated that the high-moisture IR silage exhibited good ensiling characteristics, but the potential for microbial contamination and pathogens still remained after ensiling.

Analysis and control of grid-interactive PV-fed BLDC water pumping system with optimized MPPT for DC-DC converter

In this study, a novel water pumping module fed by grid interactive Photo-Voltaic with a bidirectional Power Flow Control was proposed. In addition to improving the pumping system’s reliability, a water pump is powered by a brushless DC motor drive. This method enables the pump to work at its maximum capacity for the entirety of that day, regardless of the weather. The entire system becomes more reliable as a result of the motor’s increased use of photovoltaic (PV) generated power for pumping applications. Maximum Power Point Tracking (MPPT) controller incorporating Machine Learning algorithm drives bridgeless greater static gain DCDC converter to achieve higher power generation point and increment PV efficiency. The PV array’s operation would be managed using the ML back propagation technology to capture the most electricity under any ecological circumstance. A BLDC motor is fed by a Voltage Source Inverter (VSI) that includes a DC bus controlled in both directions by a unit vector template (UVT) approach incorporated in a single-phase voltage source converter (VSC). Additionally, utilizing a PI controller to manage the DC capacitor voltage in the UVT controller at a particular level is not appropriate for the increased PQ capabilities. However, due to tuning problems with the current controller, this controller is unpopular. The aforementioned problems are resolved by employing a unique intelligent-based fuzzy logic controller that achieves good performance features. In this technique, the function of a PV array at its Maximum Power Point (MPP), as well as power quality enhancements and a decrease in Total Harmonic Distortion (THD) of the grid are accomplished. The proposed PI controller attains a significant voltage THD of 3.736. The PI controller, on the other hand, managed to achieve a load voltage THD of 2.629%. The ANFIS method, whose value is 1.739%, is discovered to have a lower THD than all remotes with improved features, it lessens abrupt swings while maintaining steady DC-link voltage.

Combined Assessment of Function and Survival to Demonstrate the Effect of Treatment on Progressive Supranuclear Palsy.

Progressive supranuclear palsy (PSP) is a rare and fatal neurodegenerative disorder for which there are currently no disease-modifying treatments. Recent trials of potential therapies had durations of 12 months, which may be insufficient because of nonrandom missingness due to death. Longer durations, incorporating PSP Rating Scale and survival, can reduce the potential for type II error. Selecting efficacy measures more sensitive to disease modification may facilitate identification of treatment effect. The objective of this study was to evaluate the simulated phase 3 PSP trial assessing the effect of disease-modifying intervention on a novel combined primary endpoint comprising function (PSP Rating Scale) and survival, the Combined Assessment of Function and Survival (CAFS), and to determine operating characteristics of the CAFS. To simulate PSP progression in the trial population, we developed models of PSP Rating Scale and survival using data from published clinical studies. These models were used to define operating characteristics of the CAFS for use in a phase 3 trial. The sample size determined (N = 384; 1:1 randomization) would provide >80% power to detect significant treatment effects on the CAFS compared with placebo. The CAFS provides good operating characteristics and increased power to detect moderate treatment effects on the PSP Rating Scale. We propose a trial design allowing potential detection of treatment effects at a preplanned interim analysis after participants complete 12 months of treatment, with assessment of effects of treatment (≤24 months) on survival. Use of the CAFS could provide a comprehensive and robust estimate of the clinical benefit of future therapies. © 2024 UCB. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Investigation on the failure mechanism of friction-based self-centering timber beam-column joint considering bolt bearing effect: Experimental study and theoretical analyses

For friction-based self-centering timber structures, the bearing between friction bolts and the edge of holes is inevitable, due to machining inaccuracies and significant deformations at the beam-column joints. However, this issue has yet to be addressed in existing research. A limit state investigation was conducted on these friction-based self-centering timber beam-column joints under extensive deformation to analyze the failure mechanism and the loss of pretension force throughout the loading process. The influence of bolt bearing behavior on the residual deformation, loading capacity, energy dissipation capacity, and stiffness of the joint was studied. Finally, a theoretical prediction model considering single bolt and multi bolts bearing was proposed incorporating theoretical analysis and experimental results. The results indicate that the damage of the joint is concentrated on the compression deformation at the edge of bolt holes in friction pads and timber beams. The joint ultimately fails due to the end face of the column being crushed by the anchor used to fix post-tensioned (PT) strands. The joint exhibits good hysteresis characteristics within a 4 % drift and still demonstrates good recoverability within a 6 % drift. The loss rate of pretension force is below 15 % when the drift is lower than 4 %, but it increases significantly after the drift exceeds 5 %. When the drift is less than 4 %, the joints primarily exhibit single bolt bearing mode, resulting in only a slight increase in stiffness for the joints. When the drift exceeds 8 %, the joints primarily exhibit a multi bolt bearing mode, resulting in a maximum increase of approximately 64.5 % in joint stiffness. The theoretical bolt bearing model derived can better predict the position of bolts bearing the edge of holes and the damage state of friction-based self-centering timber beam-column joints.

Genome-Wide Identification and Characterization Thaumatin-like Protein (TLP) Genes in Wild Olive (Olea europaea var. sylvestris)

The wild olive tree (Olea europaea var. sylvestris) is the ancestor of all olive varieties, displaying remarkable adaptability to diverse climatic conditions and soil types. This iconic tree of the Mediterranean Basin stands out for its ability to withstand environmental stresses, such as water scarcity and temperature variations, playing a crucial role in the ecology, economy, and culture of the region. In this study, 42 TLP genes were characterized in the wild olive tree, distributed across 14 chromosomes and nine scaffolds. In silico analysis revealed the presence of domains associated with antifungal activity in some sequences, indicating their potential role in pathogen resistance. The structural diversity of OeTLP genes was explored through multiple alignments, conserved motifs and phenetic analysis. Correlation was observed between phenetic diversity, genetic structure, and motif patterns, suggesting different functions among OeTLP groups. Additionally, the distribution of exons and introns in the pheneticc tree provided further insights into the evolution of these genes. Comparative modeling of OeTLPs unveiled three-dimensional models with good structural quality and distinctive surface charge characteristics. This study provides a comprehensive understanding of the physicochemical, structural, and phenetic features of TLP genes in Wild Olive, contributing to knowledge about this species' response to environmental stresses and pathogens.

Effect of layered fertilizer strategies on rapeseed (Brassica napus L.) productivity and soil macropore characteristics under mechanical direct-sowing

Layered fertilization parameters affects crop root system configuration and growth distribution, which in turn affects soil pore properties and aggregate structure. Therefore, understanding the spatial distribution of the root system and soil pore space is helpful in choosing a reasonable fertilization ratio in production practice, which ensures high and stable crop yields and at the same time improves fertilizer utilization and soil health. Albeit the impact of layered fertilization ratio at varied rates on soil pore characteristics in the soil profile at a microscale level remains limited. This study quantifies the impacts of layered fertilization ratio under on rapeseed root distribution and soil pore characteristics using the root analysis system and X-ray computed tomography (XCT). A new fertilization pattern that shallow-deep layer synchronized mechanical sowing was using, rotary tillage mixed fertilization in the shallow layer and 10 cm side-deep band fertilization in the deeper layer. It set five ratios of fertilizer amounts between shallow and deep layers as 0:4 (FD), 1:3 (FL), 2:2 (FM), 3:1 (FH), and 4:0 (F0), with non-fertilization (CK) as the control treatment. The results indicated that layered fertilization effectively improved the rape root conformation and spatial distribution, significantly increased total soil porosity and moisture content, and reduced soil bulk density and resistance (P < 0.05). Additionally, root configuration is closely related to soil pore structure and crop yield. Notably, compared with other treatments, the macroscopic porosity, equivalent pore diameter, hydraulic radius and roundness of FM treatment are significantly improved, and it effectively improves the yield and quality of rapeseed. Correlation analysis showed that the root system configuration parameters were negatively correlated with soil bulk density and resistance but positively correlated with soil moisture content, and macropore morphology parameters and rapeseed yield. Our study demonstrate that layered fertilization can improved rape growth and soil macropore porosity, but its effect depends on good tillage macropore characteristics and distribution created by reasonable fertilization ratio, which provided a theoretical basis for high-yield, efficient, green, and sustainable mechanized direct-sowing production of rapeseed.

AGRIBISNIS KOPI DALAM MENDUKUNG PENGEMBANGAN AGROWISATA DI DESA COLOL, KECAMATAN LAMBA LEDA TIMUR, KABUPATEN MANGGARAI TIMUR (Coffee Agribusiness In Supporting Agrotourism Development In Colol Village, Lamba Leda Timur District, East Manggarai District)

Colol Village is a wilaya located in East Manggarai Regency, East Nusa Tenggara Province, which has good environmental and geographical characteristics, fertile soil and a suitable climate for coffee cultivation. The coffee varieties that are being developed are Arabica coffee and Robusta coffee. The people of East Manggarai have a cultural tradition that is close to coffee. The aim of this research is to analyze the factors that influence coffee production in Colol Village, determine farmers' perceptions of agrotourism development in Colol Village and describe the implementation of the coffee agribusiness system in Colol Village, East Manggarai Regency. This research used mixed methods with a sample size of 56 people using multiple linear regression data analysis methods, Likert scale analysis and descriptive qualitative analysis. The results of the research show that in coffee production the factors of land area, farming experience, farmer age, education level, household income, and coffee sales income level influence the development of agrotourism in Colol Village, East Manggarai Regency and based on Likert scale analysis, Colol coffee farmers agree with the development of coffee agrotourism in Colol Village and coffee production and agrotourism potential are related, the potential for coffee farming as a tourist attraction thereby strengthening the local economy and creating sustainable opportunities for the development of Colol village, East Manggarai

Fabrication and High Dielectric Properties of Sandwich-Structured Ba0.6Sr0.4TiO3/Polyvinylidene Fluoride Layered Composites with Multiscale Parallel Interfaces.

Ba0.6Sr0.4TiO3/polyvinylidene fluoride (BST/PVDF) dielectric functional composites have been widely used in flexible wearable devices, capacitors, and energy storage devices. In addition to the ceramic phase type, polymer matrix type, composition, and interfacial connectivity of BST/PVDF composite materials, their morphology also significantly influences their electrical characteristics. Therefore, herein, sandwich-structured BST/PVDF layered composites were designed and prepared via tape-casting processing using different types of BST fillers [i.e., formless zero-dimensional (0D)-BST, rod-like one-dimensional (1D)-BST, and plate-like two-dimensional (2D)-BST]. The microstructures and electrical characteristics of sandwich-structured BST/PVDF composites were studied in relation to the BST morphology. The effects of the internal mechanisms of different interfacial models on the breakdown strength of BST/PVDF composites were discussed. According to our findings, unlike the 0D-BST and 1D-BST powders, 2D-BST powders form multiscale parallel interfaces in sandwich-structured composites due to their unique lamella-like morphology, which enhances the breakdown strength of sandwich-structured composites. Sandwich-structured BST/PVDF composites containing 2D-BST powders exhibit good electrical characteristics with an energy storage density of 19.71 J/cm3, an energy storage efficiency of 85.3%, a dielectric constant of 30.4 (1 kHz), a dielectric loss of 0.036 (1 kHz), and a dielectric tunability of 93.2%. This study provides a method for preparing functional composites with high dielectric tunability and high energy storage characteristics.

Abietic acid antagonizes the anti-inflammatory effects of celecoxib and ketoprofen: Preclinical assessment and molecular dynamic simulations

The present work is designed to explore the anti-inflammatory properties of AA and its modulatory effects on celecoxib (CEL) and ketoprofen (KET) through in vitro, ex vivo, in vivo, and in silico approaches. Different concentrations of AA were utilized to evaluate the membrane-stabilizing potential via egg albumin and the Human Red Blood Cell (HRBC) denaturation model. In the animal model, formalin (50 μL) was injected into the right hind paw of young chicks to induce inflammation. AA was administered at 20 and 40 mg/kg (p.o.) to the experimental animals. We used CEL and KET as positive controls. The vehicle was provided as a control group. Two combinations of AA with CEL and KET were also investigated in all tests to assess the modulatory activity of AA. In addition, in silico investigation was used for predictions about drug-likeness, pharmacokinetics, and toxicity of the selected chemical compounds, and the study also evaluated the binding affinity, visualization, and stability of ligand-receptor interactions through molecular dynamic (MD) simulation. Results manifested that AA concentration-dependently significantly inhibited the egg albumin denaturation (IC50: 27.53 ± 0.88 μg/ml) and breakdown of HRBC (IC50: 15.69 ± 0.75 μg/ml), indicating the membrane stabilizing potential compared to the control group. AA also significantly (p < 0.05) lessened the frequency of licking and alleviated the paw edema in a dose-dependent manner in an in vivo test. However, AA reduced the activity of CEL and KET in combination treatment. AA showed good pharmacokinetic characteristics to be considered as a therapeutic candidate. Additionally, the in silico study displayed that AA demonstrated a relatively higher docking score of −9.1 kcal/mol with the cyclooxygenase-2 (COX-2) enzyme and stable binding in MD simulation. Whereas the standard ligand (CEL) expressed the highest binding value of −9.2 kcal/mol to the COX-2.

Tuning Supercapacitive Behavior of Eri Silk (Philosamiaricini)‐Polyanilne Nanocomposite for Electrodes Applications

ABSTRACTHerein, the synthesis of Polyaniline‐Eri nanosilk fibroin (PANI/ENSF) composite supercapacitor electrode material by utilizing Eri silk (Philosamiaricini) as a raw material and polyaniline (PANI) with H2SO4 as doping acid and (NH4)2S2O8 as an oxidant, via a simple in situ oxidative polymerization technique, with good performance characteristics is reported. The chemical composition of the composites have been studied by using XRD, FT‐IR, UV–vis spectroscopy, Raman spectroscopy, and morphology is studied by SEM. BET analysis reveals that the surface area of composite is 712.10 m2g−1, and BJH analysis shows that the pore size is mainly concentrated between 1.5 and 15.7 nm. The composite shows electrical conductivity of 17.33 × 10−2 Scm−1 (Keithley Model 2000). The electrochemical performances are evaluated by using CV, GCD, and EIS measurements. The three‐electrode system composite shows specific capacitance of about 310.12 Fg−1 at 0.1 Ag−1, which is the highest value being reported, compared to already available polyaniline‐silk composites. Further the studies have been extended to assemble a symmetrical two‐electrode supercapacitor device which also exhibits a high value of specific capacitance of 35 Fg−1 at 5 Ag−1 and 96.12% capacity retention over 5000 cycles. For the first time, this study reports using a Polyaniline‐Eri nanosilk composite to design an efficient supercapacitor electrode.

Responsive integration performed by laser-induced Er3+ structural doping and graphene nanoplatelets

Laser-induced preparation method has the advantages of high efficiency, high yield, no ionic diffusion restriction and competitive side reaction, which can prepare diversified composite materials based on small-scale and distributed characteristics. Besides, integrating multiple performance and conducting inductive feedback are helpful for the reliability and calibration of laser-induced materials in the precision field. Herein, responsive integration is designed based on graphene nanoplatelets/ZnSe:Er3+ composite with optical, electrical, thermal and visual properties for real-time feedback. Er3+ ions doped ZnSe is obtained by fast laser-induced method, combined with two-dimensional graphene nanoplatelets and assembled into temperature-sensitive polyimide and cellulose paper, realizing the characteristics of photoelectric conversion and photothermal conversion. Besides, red fluorescence guiding perceptual behavior can also be produced under the radiation of NIR laser. Based on the proposed composite, bionic flower is constructed, and exhibits good motion features in blooming. Meanwhile, large curvature bending, high thermal sensitivity and strong fluorescence emission are also revealed. Such performance combination design provides a convenient approach for multi signals cross feedback in soft actuator, which strengthens the monitoring and guidance of motion perceptions, and can be potentially applied in diversified fields.

Comparative study of five scab resistant apple cultivars

Vegetative and reproductive characteristics of five resistant apple cultivars budded on ‘М9-Т337’ rootstock were compared in the intensive orchard, planted at the density of 2380 trees per hectare (3.5 × 1.2 m) in the period 2017-2023. Trees were formed as tall spindle, under an insecticidal net against hail. Trees were grown under drip irrigation and sod-mulch system was applied. The cultivars FUJIONpbr and ENTERPRISE demonstrate greater trunk-cross section area, higher trees and greater crown volume to the tested cultivars. The smallest trees were noted in Cultivar GEMINI*. The lowest yield per unit area was obtained on cultivar FUJIONpbr. There was no significant difference among other cultivars. Despite of generally good characteristics the cultivar GEMINI* has relatively small fruits. Keywords: apple, vigor, productivity, fruit weight, yield

DFT, Molecular Docking, ADME, and Cardiotoxicity Studies of Persuasive Thiazoles as Potential Inhibitors of the Main Protease of SARS-CoV-2.

This study explores the capability of thiazoles as potent inhibitors of SARS-CoV-2 Mpro. Seventeen thiazoles (1-17) were screened for their linking affinity with the active site of SARS-CoV-2 Mpro and compared with the FDA-recommended antiviral drugs, Remdesivir and Baricitinib. Density Functional Theory (DFT) calculations provided electronic and energetic properties of these ligands, shedding light on their stability and reactivity. Molecular docking analysis revealed that thiazole derivatives exhibited favorable linking affinities with various functional sites of SARS-CoV-2 proteins, including spike receptor-linking zone, nucleocapsid protein N-terminal RNA linking zone, and Mpro. Notably, compounds 3, 10, and 12 displayed the best interaction with 6LZG as compared to FDA-approved antiviral drugs Remdesivir and Baricitinib, while compounds 1, 10, and 8 exhibited strong linking with 6 M3 M and also better than Remdesivir and Baricitinib. Additionally, compounds 3, 1, and 6 showed promising interactions with 6LU7 but only compound 3 performed better than Baricitinib. An ADME (Absorption, Distribution, Metabolism, and Excretion) study provided insights into the pharmacokinetics and drug-likeness of these compounds, with all ligands demonstrating good physicochemical characteristics, lipophilicity, water solubility, pharmacokinetics, drug-likeness, and medicinal chemistry attributes. The results suggest that these selected thiazole derivatives hold promise as potential candidates for further drug development.

Diversity of Improved Diploids and Commercial Triploids from Musa spp. via Molecular Markers

Banana breeding consists of obtaining diploid, triploid, and tetraploid intra- and interspecific hybrids by conventional breeding methods with the objective of aggregating characteristics of agronomic and commercial interest. Given the narrow genetic base of bananas, Embrapa’s Banana Genetic Breeding Program (BGBP) aims at crosses between improved diploids (ID) (ID × ID) and between improved diploids (ID) and commercial triploids (ID × CTP) and tetraploids (ID × CTT), in order to increase the genetic base and variability in bananas regarding agronomic traits of interest and resistance to main biotic and abiotic factors. These improved diploids are resistant to main fungal diseases such as yellow (YSD) and black Sigatoka (BSD) disease and Fusarium wilt (race 1 and subtropical race 4), the latter being one of the most devastating diseases in bananas. The genetic diversity between 22 improved diploids and seven commercial banana triploids was analyzed using DNA molecular markers. Five IRAP (Inter-Retrotransposon Amplified Polymorphism, 7 ISSR (Inter-Simple Sequence Repeats) and 12 SSR (Simple Sequence Repeat) markers were used. The genetic dissimilarity matrix was based on the Jaccard dissimilarity index; clusters were separated using the UPGMA (Unweighted Pair Group Method With Arithmetic Mean) method and cophenetic correlation of 0.8755. This study of the genetic diversity between improved diploids and commercial triploids, based on the genetic dissimilarity matrix, revealed that the most dissimilar diploids were DM23 and DM15 (74%) and DM16 and DM15 (74%). The smallest genetic distances between the improved diploids and commercial triploids were between TCGN25 and DM17 (50%) and TCN26 and DM17 (50%). The genetic distance matrix also revealed important genotypes to be used in crosses in order to maintain good characteristics in commercial triploids when crossed with improved diploids. The results of our study provide better breeding strategies for one of the largest banana-breeding programs worldwide focused on the development of banana varieties resistant to main biotic and abiotic factors.

Preparation of Paeonol Ethosomes by Microfluidic Technology Combined with Gaussians and Evaluation of Biological Activity by Zebrafish.

Paeonol, a monoterpene glycoside compound, has extensive pharmacological activities. However, its applications are restricted by poor water solubility and low bioavailability. In this study, paeonol ethosomes (PAE-ethosomes) were successfully prepared with a microfluidic method by optimizing the single factors and RSM test. The enhanced PAE-ethosomes were assessed using transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), vesicle size (VS), zeta potential (ZP), and polydispersity index (PDI). Density functional theory analysis was employed to verify the molecular interaction. The optimized RSM conditions were a phospholipid concentration of 6 mg/mL, a cholesterol concentration of 1 mg/mL, and a total flow rate of 600 μL/min with a presumed value of 60.3% and confirmation results of 61.2 ± 0.3%. The prepared PAE-ethosomes showed better storage stability and a slow-release effect. The Q n of PAE-ethosomes rose from 167.0 ± 15.8 to 272.0 ± 16.4 μg/cm2 after 24 h, which was substantially greater than that from a 25% hydroethanolic solution of paeonol, according to in vitro skin retention and transdermal absorption. The Q s of PAE-ethosomes in the skin increased by 225% with 265.5 ± 15.4 vs 81.8 ± 8.2 μg/cm2, compared with 25% hydroethanolic solution of paeonol. Molecular interaction between paeonol and lecithin by Gaussians showed that the paeonol compound may have a higher probability of spreading in the hydrophilic phosphate group ("head") position for the PAE-ethosomes. The Tg (Lyz: EGFP) transgenic zebrafish results showed that PAE-ethosomes had better anti-inflammatory effects than paeonol. The microfluidic approach was efficient with good characteristics in physics and pharmacology with the potential in pharmaceutical use.

Combining ion-pair strategy and percutaneous permeation enhancers to develop sustained-release paliperidone patch

In this study, a sustained-release paliperidone (PAL) patch was developed using a combination of ion-pair strategy and percutaneous permeation enhancers (PPEs). The ion-pair strategy was used to improve drug-adhesive miscibility and control drug release. PPEs were used to break SC barrier function to facilitate drug skin permeation. The in vitro skin permeation experiments using single-factor experiments and Box-Behnken design gave the optimized formulation, a 55 μm adhesive thickness patch with 7 % (w/w) PAL-LA (Lauric acid), 9.7 % (w/w) Plurol® Oleique CC 497 (POCC). Moreover, the pharmacokinetic study confirmed its potential in sustained-release transdermal patch with longer MRT0-t (18.35 ± 3.11 h) and higher BA (63.14 %) than the gavage group (Cmax = 6.64 ± 2.61 μg/mL, MRT0-t = 2.88 ± 1.06 h, BA = 45.70 %) without significant increasing Cmax. The mechanism study revealed that forming ion-pairs effectively modulated drug’s physicochemical properties and doubly ionic H-bond strength to improve drug miscibility in patches. To summarize, a sustained-release patch of PAL was successfully developed, which provided a strategy for sustained-release patches with good drug-polymer miscibility, drug controlled-release, and feasible drug utilization features.

Design of dual-band filtering patch antenna based on SIR multimode resonator

Abstract With the development of the communication field, more and more communication devices need multiple single-frequency antennas to work simultaneously. However, using multiple single-frequency antennas results in larger sizes. The miniaturized and dual-band communication system has become a new development trend. This paper designs a dual-band filtering patch antenna based on a multimode resonator, which is cascaded. The filter resonator part adopts step impedance resonance for branch shunt design, which can flexibly control the center frequency of two frequency bands. The filtering antenna utilizes a dual-layer substrate structure and achieves an integrated design through coupling probe feeding. This reduces the horizontal dimensions and improves miniaturization. Multiple radiation nulls are introduced outside the two-passband, and roll-off characteristics are evident. In addition, this design realizes high selectivity in the operating band. The antenna has large gains of 1.71 dBi and 6.25 dBi. It has good filtering and radiation characteristics.

EFFECTIVENESS OF PANCASILA AND CITIZENSHIP EDUCATION LEARNING

The national urgency of Pancasila and Citizenship Education in overcoming the moral decadence faced by the nation. Character education in higher education, especially through the mandatory general courses of Pancasila and Citizenship Education, is a solution to form good character in students in accordance with the mandate of Law 12 of 2012 concerning Higher Education. The research was conducted in several universities in Pontianak City, focusing on the effectiveness of the courses in fulfilling the effectiveness of the law regarding the implementation of the mandatory curriculum of Pancasila and Citizenship Education courses in the context of local society. The research uses a qualitative approach with a descriptive analysis method. The results of the research will be in the form of reports and articles proposed for publication in accredited national journals. The purpose of this study is to show the effectiveness of the Pancasila and Citizenship Education courses in forming student character, as well as what strategies have been carried out by universities to achieve the effectiveness of MKWK learning in universities in Pontianak City. The results of the research are expected to contribute to building closer cooperation between the government and universities in strengthening character education. This can be done through knowledge exchange, curriculum development, regulations, or other supporting programs to strengthen character learning at the tertiary level.

Carbazole-Bearing Conjugated Microporous Polymer Electrodes for Uranium Extraction from Seawater with Good Anti-biofouling Feature

Carbazole-Bearing Conjugated Microporous Polymer Electrodes for Uranium Extraction from Seawater with Good Anti-biofouling Feature

LPI radar waveform design based on complementary phase and discrete chaotic frequency joint coding

In order to reduce the probability of radar radiation signals being detected by enemy passive detection systems, this paper proposes a phase and frequency joint coding low intercept Radar waveform design method. Based on the linear frequency modulation signal, this method uses complementary binary code and chaotic sequence to phase encode the intra-pulse modulation. Code and frequency coding. The numerical simulation results show that the designed waveform exhibits pseudo-random characteristics in the time-frequency domain, and the low recognition performance is improved; The signal has an extremely low peak sidelobe level after matched filtering, showing excellent low intercept performance; its three-dimensional ambiguity function diagram presents an ideal “graph”. Fishing type”, with good distance, speed resolution and anti-interference characteristics.