Goal-directed Behavior Research Articles

Hot and cold executive function among pediatric attention deficit hyperactivity disorder with and without coexisting oppositional defiant disorder.

Executive function is a high-level set of cognitive processes related to goal-directed behaviors including two conceptual subtypes of hot (emotional) and cold (cognitive) executive function (to abbreviate EF). EF deficits in attention deficit hyperactivity disorder (ADHD) leads to significant social impairments in the home, school, and community. Today the type and the extent of executive function defects in ADHD are still debated in studies. We aimed to evaluate hot and cold executive function among medication-naive children with ADHD, with and without oppositional defiant disorder (ODD). Forty-five children including suffering ADHD with ODD (n= 15), without ODD (n= 15), or typically developed (TD, n= 15) participated in this cross-sectional study (the age of children was between 7 and 12 years old). The Child Symptom Inventory-4 (CSI-4) was used to screen behavioral and emotional symptoms. Wechsler Adult Intelligence Scale-Revised-Digit Span Task (WAIS-R-DST), Corsi Block Task (CBT), and Wisconsin Card Sorting Test (WCST) were used for assessing cold executive function. Assessing hot executive function was done with Delay Discounting Task (DDT) and Iowa Gambling Task (IGT). Evaluating the cold executive function, total WAIS-R-DST score, Backward DST, total CBT score, and Backward CBT were significantly lower among ADHD than TD groups (p< 0.05). Assessing the hot executive function showed that the score of DDT and IGT was significantly lower among ADHD than TD groups (p< 0.05). Both hot and cold executive functions are defective in children with ADHD, while the comorbid of ODD has no significant effect. We suggest the clinicians to consider cognitive rehabilitation interventions as a necessary treatment modality for ADHD patients.

INHIBITORY CONTROL IN CHILDREN WITH ATTENTİON DEFİCİT AND HYPERACTİVİTY DİSORDER

The article talks about inhibitory control, which is one of the executive functions in children with ADHD. These children always have impaired executive functions. However, executive dysfunction does not always mean ADHD. Evaluation of executive functions can help diagnose this neurodevelopmental disorder. One of the most common executive function deficits associated with ADHD is problems with inhibitory control. They find it difficult to control inappropriate or impulsive behavior, external interference, and therefore have trouble concentrating. Inhibition plays an important role in successful behavior, requiring the suppression of extraneous interference to focus attention, the ignoring of irrelevant cues to recall stored information, and the suppression of habitual responses to adaptive decision making. Impaired response inhibition directly affects four executive functions: working memory, self-regulation, language internalization, and restructuring. This, in turn, leads to difficulties with complex movements and goal-directed behavior, especially those related to motor control, verbal fluency, and syntax. Given the influence of inhibitory control on ADHD, the author argues that training that enhances inhibition may improve ADHD symptoms. A number of studies in this area have demonstrated the effectiveness of trainings designed to enhance inhibitory control.

Ceftriaxone reverses diet-induced deficits in goal-directed control.

Obesity is associated with numerous health risks and ever-increasing rates are a significant global concern. However, despite weight loss attempts many people have difficulty maintaining weight loss. Previous studies in animals have shown that chronic access to an obesogenic diet can disrupt goal-directed behavior, impairing the ability of animals to flexibly adjust food-seeking behavior following changes in the value of earned outcomes. Changes in behavioral control have been linked to disruption of glutamate transmission in the dorsal medial striatum (DMS), a region critical for the acquisition and expression of goal-directed behavior. The goal of this study was to test whether ceftriaxone, a beta-lactam antibiotic shown elsewhere to upregulate the expression of the glutamate transporter GLT-1, would improve goal-directed control following long-term exposure to an obesogenic diet. Male and female rats were given access to either standard chow or chow plus sweetened condensed milk (SCM) for 6 weeks. Access to SCM was ended and rats received daily injections of either ceftriaxone or saline for 6 days. Rats were then trained to press a lever to earn a novel food reward and, finally, were assessed for sensitivity to outcome devaluation. Histological analyses examined changes to GLT-1 protein levels and morphological changes to astrocytes, within the DMS. We found that ceftriaxone robustly restored goal-directed behavior in animals following long-term exposure to SCM. While we did not observe changes in protein levels of GLT-1 in the DMS, we observed that SCM induced changes in the morphology of astrocytes in the DMS, and that ceftriaxone mitigated these changes. These results demonstrate that long-term access to a SCM diet impairs goal-directed behavior while also altering the morphology of astrocytes in the DMS. Furthermore, these results suggest that ceftriaxone administration can reverse the impairment of goal-directed behavior potentially through its actions on astrocytes in decision-making circuitry.

Attention-deficit/hyperactivity disorder is associated with more alcohol problems and less substance-free reinforcement: A behavioral economics daily diary study of college student drinkers.

Behavioral economic theory suggests that alcohol risk is related to elevated alcohol reinforcing efficacy (demand) combined with diminished availability of reinforcing substance-free activities, but little research has examined these reward-related processes at the daily level in association with comorbid conditions that might influence behavioral patterns and reward. Young people with attention-deficit/hyperactivity disorder (ADHD) report high levels of risky drinking, and this risk may be due in part to elevated demand for alcohol and diminished engagement in enjoyable and valued substance-free activities. College student drinkers (N = 101; 48.5% female; 68.3% White; 18-22 years old) with (n = 51) and without (n = 50) ADHD completed 14 consecutive daily diaries (diary entry n = 1,414). We conducted a series of multilevel path models to examine (a) the associations among ADHD and average daily alcohol demand, substance-free enjoyment, and response contingent positive reinforcement (RCPR) for goal-directed behaviors; (b) the associations among concurrent daily alcohol demand, substance-free reinforcement, and RCPR for goal-directed behaviors and daily alcohol use and alcohol-related negative consequences; and (c) the moderating effect of ADHD on these within-day associations. ADHD was significantly associated with more daily alcohol-related negative consequences and less daily substance-free enjoyment and RCPR. Regardless of ADHD status, there were significant associations among behavioral economic risk factors and alcohol use and negative consequences, though effects differed within and between persons. There were no moderating effects of ADHD on within-person associations. Results expose areas of impairment specific to drinkers with ADHD and advance theory on ADHD and hazardous drinking. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Surprise-minimization as a solution to the structural credit assignment problem.

The structural credit assignment problem arises when the causal structure between actions and subsequent outcomes is hidden from direct observation. To solve this problem and enable goal-directed behavior, an agent has to infer structure and form a representation thereof. In the scope of this study, we investigate a possible solution in the human brain. We recorded behavioral and electrophysiological data from human participants in a novel variant of the bandit task, where multiple actions lead to multiple outcomes. Crucially, the mapping between actions and outcomes was hidden and not instructed to the participants. Human choice behavior revealed clear hallmarks of credit assignment and learning. Moreover, a computational model which formalizes action selection as the competition between multiple representations of the hidden structure was fit to account for participants data. Starting in a state of uncertainty about the correct representation, the central mechanism of this model is the arbitration of action control towards the representation which minimizes surprise about outcomes. Crucially, single-trial latent-variable analysis reveals that the neural patterns clearly support central quantitative predictions of this surprise minimization model. The results suggest that neural activity is not only related to reinforcement learning under correct as well as incorrect task representations but also reflects central mechanisms of credit assignment and behavioral arbitration.

Acute psychosocial stress modulates neural and behavioral substrates of cognitive control.

Acute psychosocial stress affects learning, memory, and attention, but the evidence for the influence of stress on the neural processes supporting cognitive control remains mixed. We investigated how acute psychosocial stress influences performance and neural processing during the Go/NoGo task-an established cognitive control task. The experimental group underwent the Trier Social Stress Test (TSST) acute stress induction, whereas the control group completed personality questionnaires. Then, participants completed a functional magnetic resonance imaging (fMRI) Go/NoGo task, with self-report, blood pressure and salivary cortisol measurements of induced stress taken intermittently throughout the experimental session. The TSST was successful in eliciting a stress response, as indicated by significant Stress > Control between-group differences in subjective stress ratings and systolic blood pressure. We did not identify significant differences in cortisol levels, however. The stress induction also impacted subsequent Go/NoGo task performance, with participants who underwent the TSST making fewer commission errors on trials requiring the most inhibitory control (NoGo Green) relative to the control group, suggesting increased vigilance. Univariate analysis of fMRI task-evoked brain activity revealed no differences between stress and control groups for any region. However, using multivariate pattern analysis, stress and control groups were reliably differentiated by activation patterns contrasting the most demanding NoGo trials (i.e., NoGo Green trials) versus baseline in the medial intraparietal area (mIPA, affiliated with the dorsal attention network) and subregions of the cerebellum (affiliated with the default mode network). These results align with prior reports linking the mIPA and the cerebellum to visuomotor coordination, a function central to cognitive control processes underlying goal-directed behavior. This suggests that stressor-induced hypervigilance may produce a facilitative effect on response inhibition which is represented neurally by the activation patterns of cognitive control regions.

Synergizing habits and goals with variational Bayes

Behaving efficiently and flexibly is crucial for biological and artificial embodied agents. Behavior is generally classified into two types: habitual (fast but inflexible), and goal-directed (flexible but slow). While these two types of behaviors are typically considered to be managed by two distinct systems in the brain, recent studies have revealed a more sophisticated interplay between them. We introduce a theoretical framework using variational Bayesian theory, incorporating a Bayesian intention variable. Habitual behavior depends on the prior distribution of intention, computed from sensory context without goal-specification. In contrast, goal-directed behavior relies on the goal-conditioned posterior distribution of intention, inferred through variational free energy minimization. Assuming that an agent behaves using a synergized intention, our simulations in vision-based sensorimotor tasks explain the key properties of their interaction as observed in experiments. Our work suggests a fresh perspective on the neural mechanisms of habits and goals, shedding light on future research in decision making.

Differential regulation of G protein-coupled receptor-associated proteins in the caudate and the putamen of cynomolgus macaques following chronic ethanol drinking.

The dorsal striatum is composed of the caudate nucleus and the putamen in human and non-human primates. These two regions receive different cortical projections and are functionally distinct. The caudate is involved in the control of goal-directed behaviors, while the putamen is implicated in habit learning and formation. Previous reports indicate that ethanol differentially influences neurotransmission in these two regions. Because neurotransmitters primarily signal through G protein-coupled receptors (GPCRs) to modulate neuronal activity, the present study aimed to determine whether ethanol had a region-dependent impact on the expression of proteins that are involved in the trafficking and function of GPCRs, including G protein subunits and their effectors, protein kinases, and elements of the cytoskeleton. Western blotting was performed to examine protein levels in the caudate and the putamen of male cynomolgus macaques that self-administered ethanol for 1 year under free access conditions, along with control animals that self-administered an isocaloric sweetened solution under identical operant conditions. Among the 18 proteins studied, we found that the levels of one protein (PKCβ) were increased, and 13 proteins (Gαi1/3, Gαi2, Gαo, Gβ1γ, PKCα, PKCε, CaMKII, GSK3β, β-actin, cofilin, α-tubulin, and tubulin polymerization promoting protein) were reduced in the caudate of alcohol-drinking macaques. However, ethanol did not alter the expression of any proteins examined in the putamen. These observations underscore the unique vulnerability of the caudate nucleus to changes in protein expression induced by chronic ethanol exposure. Whether these alterations are associated with ethanol-induced dysregulation of GPCR function and neurotransmission warrants future investigation.

Problem solving is embedded in context… so how do we measure it?

Problem solving encompasses the broad domain of human, goal-directed behaviors. Though we may attempt to measure problem solving using tightly controlled and decontextualized tasks, it is inextricably embedded in both reasoners' experiences and their contexts. Without situating problem solvers, problem contexts, and our own experiential partialities as researchers, we risk intertwining the research of information relevance with our own confirmatory biases about people, environments, and ourselves. We review each of these ecological facets of information relevance in problem solving, and we suggest a framework to guide its measurement. We ground this framework with concrete examples of ecologically valid, culturally relevant measurement of problem solving.

Network of Mindfulness and Difficulties in Regulating Emotions in Firefighters

ObjectivesGrowing evidence supports the role of mindfulness in regulating emotions in the general population. However, the interactive network of mindfulness facets and difficulties in regulating emotions is not well understood, which is specifically important for individuals involved in high-risk professions, such as first responders. The aim of this study was to investigate the interactive relations between mindfulness facets (acting with awareness, non-judging, describing, observing, and non-reacting), ability to regulate emotions and alcohol use in a sample of firefighters, including military veterans.MethodA sample of 685 career firefighters, of whom 154 (22.5%) are military veterans, completed measures of mindfulness and difficulties in regulating emotions. The dataset was subjected to network analysis.ResultsThe mindfulness facet non-judging was negatively related to emotion-regulation challenges, such as nonaccepting attitudes and lack of clarity, and positively related to deficits in goal-directed behaviour. Acting with awareness was negatively related to goal-directed behaviour deficits and impulsivity. Alcohol use was positively linked to impulsivity and negatively linked to describing. Overall, emotion-regulation difficulties were positively linked together, and positive links were found between most mindfulness facets. Directed network analysis found non-judging and emotion-regulation strategy as primary predictors. Non-judging acted as a protective factor, supporting other mindfulness facets, while emotion-regulation strategy exacerbated emotion-regulation challenges acted as a risk factor.ConclusionsThis network analysis demonstrated that acting with awareness and a non-judgmental attitude, facets of mindfulness, are linked to better emotion-regulation and may play protective role against impulsivity and alcohol use.

Group ICA of wide-field calcium imaging data reveals the retrosplenial cortex as a major contributor to cortical activity during anesthesia.

Large-scale cortical dynamics play a crucial role in many cognitive functions such as goal-directed behaviors, motor learning and sensory processing. It is well established that brain states including wakefulness, sleep, and anesthesia modulate neuronal firing and synchronization both within and across different brain regions. However, how the brain state affects cortical activity at the mesoscale level is less understood. This work aimed to identify the cortical regions engaged in different brain states. To this end, we employed group ICA (Independent Component Analysis) to wide-field imaging recordings of cortical activity in mice during different anesthesia levels and the awake state. Thanks to this approach we identified independent components (ICs) representing elements of the cortical networks that are common across subjects under decreasing levels of anesthesia toward the awake state. We found that ICs related to the retrosplenial cortices exhibited a pronounced dependence on brain state, being most prevalent in deeper anesthesia levels and diminishing during the transition to the awake state. Analyzing the occurrence of the ICs we found that activity in deeper anesthesia states was characterized by a strong correlation between the retrosplenial components and this correlation decreases when transitioning toward wakefulness. Overall these results indicate that during deeper anesthesia states coactivation of the posterior-medial cortices is predominant over other connectivity patterns, whereas a richer repertoire of dynamics is expressed in lighter anesthesia levels and the awake state.

Toward the Emergence of Intelligent Control: Episodic Generalization and Optimization.

Human cognition is unique in its ability to perform a wide range of tasks and to learn new tasks quickly. Both abilities have long been associated with the acquisition of knowledge that can generalize across tasks and the flexible use of that knowledge to execute goal-directed behavior. We investigate how this emerges in a neural network by describing and testing the Episodic Generalization and Optimization (EGO) framework. The framework consists of an episodic memory module, which rapidly learns relationships between stimuli; a semantic pathway, which more slowly learns how stimuli map to responses; and a recurrent context module, which maintains a representation of task-relevant context information, integrates this over time, and uses it both to recall context-relevant memories (in episodic memory) and to bias processing in favor of context-relevant features and responses (in the semantic pathway). We use the framework to address empirical phenomena across reinforcement learning, event segmentation, and category learning, showing in simulations that the same set of underlying mechanisms accounts for human performance in all three domains. The results demonstrate how the components of the EGO framework can efficiently learn knowledge that can be flexibly generalized across tasks, furthering our understanding of how humans can quickly learn how to perform a wide range of tasks-a capability that is fundamental to human intelligence.

Encoding of self-initiated actions in axon terminals of the mesocortical pathway.

The initiation of goal-directed actions is a complex process involving the medial prefrontal cortex and dopaminergic inputs through the mesocortical pathway. However, it is unclear what information the mesocortical pathway conveys and how it impacts action initiation. In this study, we unveiled the indispensable role of mesocortical axon terminals in encoding the execution of movements in self-initiated actions. To investigate the role of mesocortical axon terminals in encoding the execution of movements in self-initiated actions. We designed a lever-press task in which mice internally determine the timing of the press, receiving a larger reward for longer waiting periods. Our study revealed that self-initiated actions depend on dopaminergic signaling mediated by D2 receptors, whereas sensory-triggered lever-press actions do not involve D2 signaling. Microprism-mediated two-photon calcium imaging further demonstrated ramping activity in mesocortical axon terminals approximately 0.5s before the self-initiated lever press. Remarkably, the ramping patterns remained consistent whether the mice responded to cues immediately for a smaller reward or held their response for a larger reward. We conclude that mesocortical dopamine axon terminals encode the timing of self-initiated actions, shedding light on a crucial aspect of the intricate neural mechanisms governing goal-directed behavior.

A mathematical model for the role of dopamine-D2 self-regulation in the production of ultradian rhythms.

Many self-motivated and goal-directed behaviours display highly flexible, approximately 4 hour ultradian (shorter than a day) oscillations. Despite lacking direct correspondence to physical cycles in the environment, these ultradian rhythms may be involved in optimizing functional interactions with the environment and reflect intrinsic neural dynamics. Current evidence supports a role of mesostriatal dopamine (DA) in the expression and propagation of ultradian rhythmicity, however, the biochemical processes underpinning these oscillations remain to be identified. Here, we use a mathematical model to investigate D2 autoreceptor-dependent DA self-regulation as the source of ultradian behavioural rhythms. DA concentration at the midbrain-striatal synapses is governed through a dual-negative feedback-loop structure, which naturally gives rise to rhythmicity. This model shows the propensity of striatal DA to produce an ultradian oscillation characterized by a flexible period that is highly sensitive to parameter variations. Circadian (approximately 24 hour) regulation consolidates the ultradian oscillations and alters their response to the phase-dependent, rapid-resetting effect of a transient excitatory stimulus. Within a circadian framework, the ultradian rhythm orchestrates behavioural activity and enhances responsiveness to an external stimulus. This suggests a role for the circadian-ultradian timekeeping hierarchy in governing organized behaviour and shaping daily experience through coordinating the motivation to engage in recurring, albeit not highly predictable events, such as social interactions.

Relationships between emotion regulation strategies and executive functions in adolescence: Exploring the effects of discrete emotions and age.

Emotion regulation (ER) develops during adolescence and contributes to psychosocial adjustment. Individual differences in the development of ER strategies may be related to cognitive processes responsible for managing goal-directed behaviors, namely executive functions (EFs). This study examined (1) examined how difficulties in specific EFs (i.e., inhibition, flexibility and working memory) predict the use of ER strategies (i.e., reappraisal, distraction, expressive suppression, rumination, support-seeking) in an emotion-specific approach and (2) investigated these links across three different age groups (corresponding to early, middle and late adolescence), considering the nonlinear evolution of the relationships between EF and ER strategies during adolescence. The sample was composed of 1076 adolescents aged from 12 to 19 years old who completed questionnaires on EF difficulties (i.e., inhibition, flexibility, and working memory) and ER strategies (i.e., distraction, reappraisal, expressive suppression, social support-seeking, and rumination). Results showed various complex relationships between EFs and ER. Flexibility issues were related to rumination at all ages, while inhibition and flexibility difficulties were negatively linked to reappraisal in mid- to late adolescence. Many relationships were emotion- and age-dependent. These findings support the link between cognitive and emotional regulatory processes. Its complex evolution during adolescence opens a new avenue for future research.

Emotional Subjectivity in English Language Teachers' Professional Development

AbstractThis article examines emotion and its characteristics from both a western and an eastern perspective. It examines religious, philosophical, sociocultural, and neuropsychological viewpoints, as well as the role of emotion in self- and goal-directed behavior. It includes eastern insights from the Bhagavad Gita, as well as from an analysis of Bharatnatyam and Bhaktismriti, which emphasizes emotion as a devotional force and a performative strength. It also corroborates research studies that examine emotion as a research issue for English language teaching and learning. It explores possible dimensions of emotion as a devotional value, an aesthetic performative force, and a strength for self-regulated growth. It aims to present emotional subjectivity as an essential component of English language teachers' self-directed professional development. In the discussion and analysis of the research issue on English language teachers' professional growth, emotion is essentialized as a subjective element beyond the cognitive domain. This research study is beneficial for teacher educators, policymakers, trainers, and researchers since it presents a conceptual framework for emotion and its attributes for professional development.

Understanding the desire for green consumption: Norms, emotions, and attitudes

Building on goal-directed behavior premises, this article sets out to develop a framework for explaining why consumers desire green products. Informed by a qualitative study exploring critical consumption incidents, the new model of green goal-directed behaviors (MGGB) presents a unique approach, tested empirically through a survey on the sustainable food consumption of 474 U.S. consumers. By combining the effects of pro-environmental and self-oriented motivations, the MGGB achieved a superior fit and predictive power compared to rival frameworks. Structural equation modeling results unveiled the salient role of personal norms, associated with affective and evaluative mechanisms. The important function of social and cognitive aspects is also revealed. The novel approach taken herein overcomes the limitations of rational theories, by introducing new processes, and showing how their contingency on outcome expectancies and consumer involvement regulates the arousal of green consumption desires. Important considerations are derived for theory development, future research, and marketing practice.

Left OFC Activation in Functional Near-Infrared Spectroscopy during an Inhibitory Control Task in an Early Years Sample: Integrating Stress Responses with Cognitive Function and Brain Activation.

Previous functional near-infrared spectroscopy (fNIRS) studies using Go/No-Go (GNG) tasks have focused on brain activation in relation to cognitive processes, particularly inhibitory control (IC). The results of these studies commonly describe right hemispheric engagement of the dorsolateral, ventromedial, or inferior frontal regions of the prefrontal cortex. Considering that typical healthy cognitive development is negatively correlated with higher cortisol levels (which may alter brain development), the overarching aim of the current study was to investigate how elevated stress (due to unforeseeable events such as the pandemic) impacts early cognitive development. In this study, we examined fNIRS data collected from a sample of children (aged 2-4 years) during a GNG task relative to the response to stressors measured via hair cortisol concentrations. We acquired data in an ecological setting (Early Childhood Education and Care) during the coronavirus pandemic. We found that children with higher stress levels and a less efficient IC recruited more neural terrain and our group-level analysis indicated activation in the left orbitofrontal area during IC performance. A contextual stressor may disrupt accuracy in the executive function of IC early in development. More research efforts are needed to understand better how an orbitofrontal network subserves goal-directed behavior.

Hypothalamic neuronal activation in non-human primates drives naturalistic goal-directed eating behavior

Maladaptive feeding behavior is the primary cause of modern obesity. While the causal influence of the lateral hypothalamic area (LHA) on eating behavior has been established in rodents, there is currently no primate-based evidence available on naturalistic eating behaviors. We investigated the role of LHA GABAergic (LHAGABA) neurons in eating using chemogenetics in three macaques. LHAGABA neuron activation significantly increased naturalistic goal-directed behaviors and food motivation, predominantly for palatable food. Positron emission tomography and magnetic resonance spectroscopy validated chemogenetic activation. Resting-state functional magnetic resonance imaging revealed that the functional connectivity (FC) between the LHA and frontal areas was increased, while the FC between the frontal cortices was decreased after LHAGABA neuron activation. Thus, our study elucidates the role of LHAGABA neurons in eating and obesity therapeutics for primates and humans.

Ecological dynamics approach in physical education to promote cognitive skills development

The aim of this paper is to carry out a theoretical transposition of the principles of the ecological dynamic approach in the field of physical and sports education, aimed at defining educational approaches capable of promoting an effective acquisition of cognitive skills, through the practice of physical activity and sport. Physical education, according to an ecological dynamics perspective, considers the performer a complex adaptive system, which interacts with the environments in a functionally integrated way, underlining the interrelationship between motor processes, cognitive and perceptive functions. The cognitive area of Life Skills (Cognitive Life Skills, CLS), divided by the WHO, into decision making, problem solving, creative thinking and critical thinking processes, can be framed as an intrinsic part of goal-directed behaviour influenced by functional constraints determined by individual-environment interaction. Therefore, physical and sport activity practiced according to the principles of the ecological dynamic approach can be configured as an elective tool to promote the development of cognitive skills. In this article, the relevant theories of ecological dynamics are discussed and recent empirical data on the perceptual-cognitive processes which are activated through the practice of physical education and sport are described to underline the potential of such practices for the development of cognitive skills. The development of this specific theoretical transposition represents a starting point for the definition and experimentation of ecological dynamic interventions designed with the aim of investigating the effects of physical and sporting activity on the development of cognitive skills for life.