In this paper, an ultra-sensitive bio-sensor based on the GMR effect in self-suspended-membrane-type gratings (SSGs) is proposed using multilayer plane waveguide theory. It is demonstrated from our calculations that the sensitivity of our bio-sensor is near the theoretical limit compared with a conventional GMR sensor. Based on the normalized eigenfunction of a single-layer homogeneous grating, the resonance curves with respect to different refractive indices of surrounding media are calculated, which confirm the estimated sensitivity. In addition, we design a highly sensitive bio-sensor in the near- and mid-IR wavelength region for liquid and gas detection respectively, the sensor can deliver a resolution over 1 × 10−5 in the near-IR region in a large refractive index (1.3–1.7) range and provide better than 1 × 10−6 in the mid-IR region, which is enough for various bio-material detections. Therefore, the bio-sensor we proposed is one or two orders more sensitive than conventional GMR sensors.
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