Red Blood Cell Glycolysis Research Articles

STUDIES ON THE PRESERVATION OF BLOOD: III. REVERSIBLE INHIBITION OF GLYCOLYSIS IN BLOOD BY OXALATE

Oxalate was found to inhibit glycolysis in red blood cells during storage at 5 °C. The inhibition of glycolysis in blood cells by oxalate is reversible. The glycolytic activity of the oxalated cells can be restored by washing the cells, or by precipitating the oxalate with an equivalent concentration of added calcium ions. However, with increased duration of storage prior to removal of oxalate the rate of glycolysis in the erythrocytes was found to be decreased on removal of the oxalate.