Hydrogels are emerging as important materials to achieve medical advances, in applications such as cellular scaffoldings in regenerative medicine/tissue engineering, tissue replacements, wound dressings, and drug/gene/protein/RNA delivery systems among others. This is due to their high-water content and their similarities to the structural form of living tissues. Hydrogels are most useful when they can be compatible with the dynamics of healthy tissues, while at the same time they are able to deliver therapeutic molecules at specified locations.In this talk, I will present our recent work in using fullerenes and their derivatives for biomedical engineering. Fullerenes are attractive for a number of reasons: their surface can be functionalised to enhance their biocompatibility and water solubility; they can encapsulate molecules in endohedral form, and they have shown antiviral, antibacterial and antioxidant activity. The physical properties of fullerenes make them ideal candidates to produce supramolecular structures and hydrogels without the need for an external polymeric matrix. I will show the synthesis of supramolecular hydrogels solely from covalently-functionalised C60. I will also demonstrate the synthesis of new kinds of supramolecular hydrogels made from fullerenes of different sizes (C60, C84 and C90–92) functionalised with hydrophilic oligoethylene glycol chains. Carrying out the reaction on fullerenes of different sizes, including C70, allows us to interrogate the effect of fullerene shape on chemical functionalization, and thus, self-assembly behaviour.We believe these fullerene hydrogels may have biomedical applications. Furthermore, they maybe sought after for electrochemical applications such as next-generation capacitors.