Glutathione Levels In Rats Research Articles

The effect of chronic ethanol ingestion on brain lipid peroxide and glutathione levels in rats

Rat liver and brain lipid peroxide and glutathione levels were determined after chronic ethanol treatment. Although hepatic lipid peroxidation was significantly stimulated, we have failed to observe any change in brain lipid peroxide and glutathione levels of rats chronically treated with ethanol.

The effects of ethylene oxide (EO) exposure on tissue glutathione levels in rats and mice.

Male Fischer 344 rats and male Swiss-Webster mice were exposed to different atmospheric concentrations of ethylene oxide (EO) for 4 hours. In mice sacrificed immediately after exposure to 100, 450 or 900 ppm EO, there was a concentration related decrease in the GSH levels of all tissues examined. Similar findings were obtained in rats immediately after exposure to 100, 600 or 1200 ppm EO except that blood GSH levels were not affected at any exposure concentration. In both species, lung and liver GSH levels were depressed at all exposure concentrations. Twenty-four hours after exposure to 1200 ppm EO, the GSH concentrations of rat bone marrow and testis had not returned to control levels. Only blood GSH levels remained depressed in mice 48 hours after exposure to 900 ppm EO. The results indicate a marked species difference between rats and mice regarding the effects of EO exposure on blood GSH levels which may have important toxicological implications.

Influence of experimental diets on hepatic glutathione levels in rats with methylnitrosourea-induced mammary carcinoma.

Mammary tumor development induced by methylnitrosourea in female Sprague-Dawley rats had no significant effect on hepatic glutathione levels. If the diets of methylnitrosourea-treated animals were supplemented with vitamin A and E an increased hepatic glutathione level was observed initially. A high fat diet (21% per weight) supplemented with the two vitamins led to a decreased hepatic glutathione level 2 months after tumor induction. Advanced tumor development under any of the diets tested had no effect on hepatic glutathione.

Effect of total body x-irradiation on glutathione levels in rats.

SummaryA study has been made of blood and liver glutathione after 500 r total body x-irradiation. The data show first, that irradiation generally causes a decrease in blood glutathione; and second, in some cases, a decrease in liver glutathione.