Glucose Entry Rate Research Articles

GLUCOSE KINETICS IN NORMAL, FASTING, AND INSULIN-TREATED COWS.

Plasma glucose concentration in four cows averaged 58 mg/100 ml. It fell to 48 mg/100 ml during fasting, and to 29 mg/100 ml when long-acting insulin was given daily. From 45 until 150 min after a single injection of glucose-C14 the curves for plasma glucose specific activity plotted logarithmically against time approximated straight lines. The line during fasting lay above the normal line, while the line during insulin treatment fell below it. This suggests that there are two types of hypoglycemia, distinguished by different changes in the glucose pool. Characteristics of the pool sampled as plasma glucose were calculated from the slope and intercept of the lines from 45 to 150 min after injection. During fasting, the amount of exchangeable glucose fell to two-thirds and the glucose entry rate to half normal. This suggests that hypoglycemia develops during fasting because glucose utilization (outflow) exceeds glucose formation (inflow) with a decrease in the amount of glucose. In contrast, during insulin administration, the amount of exchangeable glucose was greater than normal, the entry rate was increased by one-third, and the apparent volume of glucose distribution was increased to 64% of the body weight. This suggests that insulin-induced hypoglycemia is due to an increase in the glucose "space" associated with the accumulation of exchangeable glucose inside some cells.

Further studies on the entry rates of acetate and glucose in sheep, with special reference to endogenous production of acetate.

Research Article| September 01 1962 Further studies on the entry rates of acetate and glucose in sheep, with special reference to endogenous production of acetate EF ANNISON; EF ANNISON Search for other works by this author on: This Site PubMed Google Scholar RR WHITE RR WHITE Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1962) 84 (3): 546–552. https://doi.org/10.1042/bj0840546 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Citation EF ANNISON, RR WHITE; Further studies on the entry rates of acetate and glucose in sheep, with special reference to endogenous production of acetate. Biochem J 1 September 1962; 84 (3): 546–552. doi: https://doi.org/10.1042/bj0840546 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1962 The Biochemical Society1962 Article PDF first page preview Close Modal You do not currently have access to this content.

Effects of insulin on blood glucose entry and removal rates in man.

Effects of insulin on blood glucose entry and removal rates in man.

EFFECTS OF INSULIN ON BLOOD GLUCOSE ENTRY AND REMOVAL RATES IN NORMAL DOGS

EFFECTS OF INSULIN ON BLOOD GLUCOSE ENTRY AND REMOVAL RATES IN NORMAL DOGS