SARS-CoV-2 has made the world come to a halt, causing unprecedented global protocols and rules being implemented. Many different characteristics of this virus emerged early on. A notable characteristic that was noticed was the disparity in COVID-19 severity between the two biological genders, with males having a significantly higher fatality rate in comparison to females. As studies continue to understand this disparity, this literature review intends to summarize a few of these findings. Research on these studies were found on public research engines like ScienceDirect, Biology Medcentral, and PubMed. Papers were all peer reviewed. Another tool that was used was from the Global Health 50/50 research initiative which provided sex dis-aggregated data on COVID-19 in all countries that had accessible data. Studies have indicated that genetic factors, lifestyle factors, and “other” factors are all reasons for the disparity. T-Cell and ACE2 protein amount difference in males and females have been suggested as possible reasons for the discrepancy. Studies have also suggested that increased COVID-19 viral load also increases infection severity. This is relevant as male attitudes towards COVID-19 public health guidelines are more relaxed compared to females. Other possible factors that could play into this disparity is smoking, with active smokers having increased COVID-19 infection severity. This relates to the fact that the percent of male smokers is much higher than females. These lifestyle factors are further supported by the fact that males have higher fatality rates in respiratory tract diseases including SARS and influenza.
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