Currently, mobile robots are developing rapidly and are finding numerous applications in the industry. However, several problems remain related to their practical use, such as the need for expensive hardware and high power consumption levels. In this study, we build a low-cost indoor mobile robot platform that does not include a LiDAR or a GPU. Then, we design an autonomous navigation architecture that guarantees real-time performance on our platform with an RGB-D camera and a low-end off-the-shelf single board computer. The overall system includes SLAM, global path planning, ground segmentation, and motion planning. The proposed ground segmentation approach extracts a traversability map from raw depth images for the safe driving of low-body mobile robots. We apply both rule-based and learning-based navigation policies using the traversability map. Running sensor data processing and other autonomous driving components simultaneously, our navigation policies perform rapidly at a refresh rate of 18 Hz for control command, whereas other systems have slower refresh rates. Our methods show better performances than current state-of-the-art navigation approaches within limited computation resources as shown in 3D simulation tests. In addition, we demonstrate the applicability of our mobile robot system through successful autonomous driving in an indoor environment.