Abstract Climate feedback analysis constitutes a useful framework for comparing the global mean surface temperature responses to an external forcing predicted by general circulation models (GCMs). Nevertheless, the contributions of the different radiative feedbacks to global warming (in equilibrium or transient conditions) and their comparison with the contribution of other processes (e.g., the ocean heat uptake) have not been quantified explicitly. Here these contributions from the classical feedback analysis framework are defined and quantified for an ensemble of 12 third phase of the Coupled Model Intercomparison Project (CMIP3)/Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report (AR4) coupled atmosphere–ocean GCMs. In transient simulations, the multimodel mean contributions to global warming associated with the combined water vapor–lapse-rate feedback, cloud feedback, and ocean heat uptake are comparable. However, intermodel differences in cloud feedbacks constitute by far the most primary source of spread of both equilibrium and transient climate responses simulated by GCMs. The spread associated with intermodel differences in cloud feedbacks appears to be roughly 3 times larger than that associated either with the combined water vapor–lapse-rate feedback, the ocean heat uptake, or the radiative forcing.