Event Abstract Back to Event Effects of Subthalamic Nucleus-Deep Brain Stimulation alone or in combination with Levodopa therapy on cortex excitability in Parkinson’s disease. A TMS/EEG study. Mario Stampanoni Bassi1, 2*, Maria Concetta Pellicciari2, Viviana Ponzo2, Elias Paolo Casula2, Alessandro Stefani1 and Giacomo Koch2, 3 1 Department of System Medicine, Policlinico di Tor Vergata, Rome, Italy, Italy 2 Non-Invasive Brain Stimulation Unit, Neurologia Clinica e Comportamentale, Fondazione Santa Lucia IRCCS, Italy 3 Stroke Unit, Policlinico Tor Vergata, Rome, Italy, Italy Introduction: In Parkinson’s disease (PD), Deep Brain Stimulation (DBS) of the Subthalamic Nucleus (STN) represents an effective therapy. It is of interest to understand whether STN-DBS exerts specific effects (different from levodopa) on cortical reactivity. Using a combined Transcranial Magnetic Stimulation (TMS)/EEG approach, we explored the effects STN-DBS, either alone or in combination with Levodopa (LD), on cortical excitability evoked by stimulation of the primary motor cortex. Methods: Six advanced PD patients treated with STN-DBS were tested in 3 clinical conditions, on distinct days: 1st. Ther-On/Stim-On (2 h after the first daily dose of standard medication); 2nd. Ther-Off/Stim-On (after overnight therapy withdrawal); 3rd. Ther-Off /Stim-Off (as in the second condition but the stimulus was switched Off 90’ in advance). Motor performances were evaluated by UPDRS part III. In each condition, 80 single pulse TMS were delivered over M1, contralateral to the clinically more affected side while acquiring EEG. To evaluate changes in the cortical field strength evoked by the TMS pulse Global Mean Field Power (GMFP) was computed for each subject in the three conditions. ANOVA for repeated measures was performed on the peaks observed in the GMFP with the factors Condition and Peak. Results: TMS evoked a cortical activity lasting up to 300 ms; four main components were identified, that showed similar latencies and were reproducible across subjects. STN stimulation induced a significant increment of the component peaking at 60-70 ms compared to Ther-Off/Stim-Off condition. In Ther-On/Stim-On condition a significant increment of component at 100ms component was observed, when compared to either Ther-Off/Stim-Off or STN-DBS alone. Conclusion: Our data show that bilateral STN-DBS induces a significant modulation of cortical global reactivity. The association of LD therapy produces distinct neurophysiological effects in line with the clinical additional efficacy. Keywords: deep brain stimulation (DBS), Subthalamic Nucleus, TMS/EEG co-registration, Levodopa, Parkinson's disease (PD) Conference: 5th Biennial Workshop on Dystonia: “Controversies in Dystonia and Parkinsonism” | Nobile Collegio Chimico Farmaceutico, Rome, May 29-30, 2015, Rome, Italy, 29 May - 30 May, 2015. Presentation Type: Poster presentation Topic: Parkinson's disease Citation: Stampanoni Bassi M, Pellicciari M, Ponzo V, Casula E, Stefani A and Koch G (2015). Effects of Subthalamic Nucleus-Deep Brain Stimulation alone or in combination with Levodopa therapy on cortex excitability in Parkinson’s disease. A TMS/EEG study.. Front. Neurol. Conference Abstract: 5th Biennial Workshop on Dystonia: “Controversies in Dystonia and Parkinsonism” | Nobile Collegio Chimico Farmaceutico, Rome, May 29-30, 2015. doi: 10.3389/conf.fneur.2015.57.00008 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 May 2015; Published Online: 08 May 2015. * Correspondence: Dr. Mario Stampanoni Bassi, Department of System Medicine, Policlinico di Tor Vergata, Rome, Italy, Rome, Italy, m.stampanonibassi@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Mario Stampanoni Bassi Maria Concetta Pellicciari Viviana Ponzo Elias Paolo Casula Alessandro Stefani Giacomo Koch Google Mario Stampanoni Bassi Maria Concetta Pellicciari Viviana Ponzo Elias Paolo Casula Alessandro Stefani Giacomo Koch Google Scholar Mario Stampanoni Bassi Maria Concetta Pellicciari Viviana Ponzo Elias Paolo Casula Alessandro Stefani Giacomo Koch PubMed Mario Stampanoni Bassi Maria Concetta Pellicciari Viviana Ponzo Elias Paolo Casula Alessandro Stefani Giacomo Koch Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.