A rectangular cylinder, with an aspect ratio of 5, is a widely used bluff body in engineering practice. It undergoes intricate dynamical behavior in response to minute alterations in the flow angle of attack (α). These modifications invariably precipitate the failure of wake control for classical flow control methods with various α values. In this study, global linear instability, adjoint method, and sensitivity analysis are employed to identify the optimal position for flow control. It is found that the sensitive region gradually transitions from the leeward side to the downwind side of the model as α and Reynolds number (Re) increase. So, we set up airflow orifices for flow control in both positions. Jet flow control on the leeward side effectively inhibits vortex shedding (α ≤ 2°). High-order dynamic mode decomposition is employed to reveal the inherent mechanism of control. Suction control on the downside effectively mitigates the shear layer separation phenomenon induced by the altered spatial structure associated with higher α. A novel zero-net-mass-flux wake control, bionics-based breathe-valve control (BVC), is proposed to optimize the control effect. BVC is applicable for various α and Re, with optimal effectiveness achievable through jet velocity adjustments. The prediction-control approach in this investigation provides a targeted method to mitigate flow-induced vibration.