Global Form Perception Research Articles

Contrast Discrimination and Global Form Perception in Primary Open-Angle Glaucoma and Primary Angle-Closure Glaucoma.

This study explored early (contrast discrimination) and intermediate (global form perception) visual processing in primary subtypes of glaucoma: primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). We aimed to understand early and intermediate visual processing in POAG and PACG, matched for similar visual field defect severity. Early visual processing was measured using a contrast discrimination task described by Porkorny and Smith (1997), and intermediate processing using a global form perception task using glass pattern coherence thresholds. Thresholds were determined centrally and at a single midperipheral location (12.5°) in a quadrant without visual field defects. Controls were tested in corresponding quadrants to individuals with glaucoma. Sixty participants (20 POAG, 20 PACG, and 20 age-matched controls), aged 50 to 77years, were included. Visual field defects were matched between POAG and PACG, with mean deviation values of -6.53 ± 4.46 (range: -1.5 to -16.85) dB and -6.2 ± 4.24 (range: -1.37 to -16.42) dB, respectively. Two-Way ANOVA revealed significant differences in thresholds between the glaucoma groups and the control group for both contrast discrimination and global form perception tasks, with higher thresholds in the glaucoma groups. Post hoc analyses showed no significant contrast discrimination difference between POAG and PACG, but POAG had significantly higher thresholds than PACG for form perception. In form perception, POAG showed slightly worse performance than PACG, suggesting that individuals with POAG may experience more severe functional damage than PACG of similar visual field severity.

Differential functional reorganization of ventral and dorsal visual pathways following childhood hemispherectomy

Hemispherectomy is a surgical procedure in which an entire hemisphere of a patient’s brain is resected or functionally disconnected to manage seizures in individuals with drug-resistant epilepsy. Despite the extensive loss of both ventral and dorsal visual pathways in one hemisphere, pediatric patients who have undergone hemispherectomy show a remarkably high degree of perceptual function across many domains. In the current study, we sought to understand the extent to which functions of the ventral and dorsal visual pathways reorganize to the contralateral hemisphere following childhood hemispherectomy. To this end, we collected fMRI data from an equal number of left and right hemispherectomy patients who completed tasks that typically elicit lateralized responses from the ventral or the dorsal pathway, namely, word (left ventral), face (right ventral), tool (left dorsal), and global form (right dorsal) perception. Overall, there was greater evidence of functional reorganization in the ventral pathway than in the dorsal pathway. Importantly, because ventral and dorsal reorganization was tested within the very same patients, these results cannot be explained by idiosyncratic factors such as disease etiology, age at the time of surgery, or age at testing. These findings suggest that because the dorsal pathway may mature earlier, it may have a shorter developmental window of plasticity than the ventral pathway and, hence, be less malleable after perturbation.

Impairment of visual and neurologic functions associated with agrochemical use.

To determine whether exposure to occupational levels of agrochemicals is associated with a range of low- (contrast and colour) and higher-level visual functions, particularly the detection of global form and motion coherence. We compared the performance of workers exposed to occupational levels of pesticides and non-exposed individuals on visual tasks that measured colour discrimination (Farnsworth Munsell 100 and Lanthony D15 desaturated) and the contrast sensitivity function (1-16 cpd). Global form and motion detection thresholds were measured using Glass-pattern and global dot motion stimuli. Neurotoxicity symptoms and biological markers associated with pesticide exposure were quantified using the Q16 modified questionnaire and via tests for levels of acetylcholinesterase in blood and substance P from the tear film, respectively. Workers exposed to pesticides had significantly more neurotoxic symptoms than non-exposed workers. No significant difference between groups for acetylcholinesterase levels was found, but there was a significant group difference in Substance P. The exposed group also had significantly poorer contrast sensitivity, colour discrimination and higher coherence detection thresholds for global form and motion perception. Exposure to occupational levels of agrochemicals in workers with signs of neurotoxicity is associated with low and high visual perception deficits.

Associations Between Autism Spectrum Quotient and Integration of Visual Stimuli in 9-year-old Children: Preliminary Evidence of Sex Differences.

The dorsal stream vulnerability hypothesis posits that the dorsal stream, responsible for visual motion and visuo-motor processing, may be particularly vulnerable during neurodevelopment. Consistent with this, autism spectrum disorder (ASD) has been associated with deficits in global motion integration, though deficits in ventral stream tasks, such as form identification, have also been reported. In the current study, we examined whether a similar pattern of results is found in a cohort of 381 children born with neurodevelopmental risk factors and exhibiting a wide spectrum of caregiver-reported autistic traits. We examined the associations between global motion perception, global form perception, fine motor function, visual-motor integration, and autistic traits (autism spectrum quotient, AQ) using linear regression, accounting for possible interactions with sex and other factors relevant to neurodevelopment. All assessments of dorsal stream function were significantly associated with AQ such that worse performance predicted higher AQ scores. We also observed a significant sex interaction, with worse global form perception associated with higher AQ in boys (n = 202) but not girls (n = 179). We found widespread associations between dorsal stream functions and autistic traits. These associations were observed in a large group of children with a range of AQ scores, demonstrating a range of visual function across the full spectrum of autistic traits. In addition, ventral function was associated with AQ in boys but not girls. Sex differences in the associations between visual processing and neurodevelopment should be considered in the designs of future studies.

Isolating Global Form Processing Using Shape Metamers

A critical disconnect between human and machine vision is that people have a remarkable ability to represent and understand the shapes of objects, whereas deep convolutional neural networks (CNNs) operate more as local texture analyzers with no propensity to perceive global form. To isolate and study the representation of global form, we developed a novel stimulus manipulation which enables us to probe global form similarity in a way that is completely isolated from local similarity. Specifically, our method renders natural images as a composition of Gabor elements of different orientations and scales. From this basis, we generate shape metamers--image pairs that differ at each local gabor, but share the same global form information and are nearly perceptually indistinguishable by humans. And, we generate anti-metamers — image pairs that differ by the same amount locally, but disrupt global form information, and look nothing alike to humans. Leveraging these stimuli as a litmus test for global form perception, we find that CNNs trained to do object categorization show little sensitivity to global form information in their feature spaces, which encode both the shape metamers and anti-metamers as equally similar. However, we find that both vision transformer models with self-attention layers, as well as our simpler custom models with hand-designed “association fields,” can learn longer-range relationships between local features, and have increased sensitivity to global form. These findings highlight that the CNN model lacks sufficient inductive biases to learn global form information, and that self-attention and association field mechanisms may serve as key precursor operations which amplify relevant local features. We propose this multiplicative operation is critical to enable downstream mechanisms to encode relationships between primarily shape-defining local features, en route to a more explicit global shape representation.

The role of color contrast gain control in global form perception.

A Glass pattern consists of randomly distributed dot pairs, or dipoles, whose orientation is determined by a geometric transform, which defines the global percept perceived by an observer. The perception of Glass patterns involves a local process that associates dot pairs into dipoles and a global process that groups the dipoles into a global structure. In the present study, we used a variant of Glass patterns, which was composed of randomly distributed tripoles instead of dipoles, to estimate the influence of color contrast on perceptual grouping. Each tripole contained an anchor dot and two context dots. Grouping the anchor dot with one of the context dots resulted in a global percept of a clockwise spiral, while grouping with the other dot, a counter-clockwise spiral. All dots in each pattern were modulated in the same color direction but different contrasts. Four colors were involved, namely, red, green, blue, and yellow. The observers were to determine whether the spiral in each trial was clockwise or counter-clockwise. The probability of a context dot being grouped with the anchoring dot increased with its color contrast to a certain level, then decreased when the contrast continued to increase. Such probability decreased as the contrast of the other context dot increased. Our result cannot be explained by existing models in the literature, but with a divisive inhibition model. The equiluminance contrast result observed here is similar to the inverted U-shaped function for luminance contrast result previously reported by us, except that the color contrast model comprises a weaker self-inhibition component.

Contributed Session II: Evidence for a dipper effect in the perception of global form: findings from psychophysics and EEG.

Decades of psychophysical experiments have shown that the perception of low luminance contrast violates Webers' law: contrast discrimination is best at low (but non-zero) pedestal intensities. This "dipper effect" is thought to be the product of a sigmoidal neuronal transducer function in the early stages of visual processing which is expansive at low contrasts. Here, we ask 1) whether the transducer that governs the perception of global form is subject to a similar nonlinearity and 2) if sensitivity is biased towards a certain axis of pattern alignment (translational, radial, concentric). Using a combination of psychophysics and steady-state VEPs, we examined observers' sensitivity to global form by manipulating the dipole orientation coherence of Glass patterns. Our psychophysical data indicate a Glass pattern "dipper effect" that is strongest for concentric patterns, while our EEG results show some evidence of nonlinear transduction but do not have the form predicted by psychophysical thresholds. Our findings indicate that, like low-level contrast, mid-level form discrimination is subject to mild facilitation (relative to detection) at low global form coherences, and suggest that this could be driven by neurons with nonlinear transducer functions.

Effect of Age and Refractive Error on Local and Global Visual Perception in Chinese Children and Adolescents.

PurposeThis study investigated the impact of age and myopia on visual form perception among Chinese school-age children.MethodsThis cross-sectional study included 1,074 students with a mean age of 12.1 ± 4.7 (range = 7.3–18.9) years. The mean spherical equivalence refraction (SER) of the participants was −1.45 ± 2.07 D. All participants underwent distance visual acuity (VA), refraction measurement and local and global visual form perception test including orientation, parallelism, collinearity, holes and color discrimination tasks.ResultsThe reaction times of emmetropes were slower than those of myopic and high myopic groups on both local (orientation, parallelism, and collinearity) and global discrimination tasks (all p < 0.05). A reduction in reaction times was found with increasing age on both local and global discrimination tasks (all p < 0.05). Age was significantly associated with both local and global visual perception performance after adjusting for gender, visual acuity and SER (orientation, β = −0.54, p < 0.001; parallelism, β = −0.365, p < 0.001; collinearity, β = −0.28, p < 0.001; holes, β = −0.319, p < 0.001; color, β = −0.346, p < 0.001).ConclusionsThis study revealed that both local and global visual perception improve with age among Chinese children and that myopes seem to have better visual perception than emmetropes.

Temporal characteristics of global form perception in translational and circular Glass patterns

The human visual system is continuously exposed to a natural environment with static and moving objects that the visual system needs to continuously integrate and process. Glass patterns (GPs) are a class of visual stimuli widely used to study how the human visual system processes and integrates form and motion signals. GPs are made of pairs of dots that elicit a strong percept of global form. A rapid succession of unique frames originates dynamic GPs. Previous psychophysical studies showed that dynamic translational GPs are easier to detect than the static version because of the spatial summation across the unique frames composing the pattern. However, it is not clear whether the same mechanism is involved in dynamic circular GPs. In the present study, we psychophysically investigated the role of the temporal and spatial summation in the perception of both translational and circular GPs. We manipulated the number of unique frames in dynamic GPs and the update rate of the frames presentation. The results suggest that spatial and temporal summation across unique frames takes place for both translational and circular GPs. Moreover, the number of unique frames and the pattern update rate equally influence the discrimination thresholds of translational and circular GPs. These results show that form and motion integration is likely to be processed similarly for translational and circular GPs.

Developmental trajectories of global motion and global form perception from 4 years to adulthood

Literature on the development of global motion and global form perception demonstrated their asynchronous developmental trajectories. However, former studies have failed to clearly establish the critical period of maturation for these specific abilities. This study aimed to analyze the developmental trajectories of global motion and global form discrimination abilities by controlling for basic visual functions and general cognitive ability and to present the global motion and global form normative scores. A sample of 456 children and adolescents (4–17 years of age) and 76 adults recruited from the Italian and Swedish general population participated in the study. Motion and form perception were evaluated by the motion coherence test and form coherence test, respectively. Raven’s matrices were used to assess general cognitive ability, the Lea Hyvärinen chart test was used for full- and low-contrast visual acuity, and the TNO test was used for stereopsis. General cognitive ability and basic visual functions were strongly related to motion and form perception development. Global motion perception had an accelerated maturation compared with global form perception. For motion perception, an analysis of the oblique effect’s development showed that it is present at 4 years of age. The standardized scores of global motion and form coherence tests can be used for clinical purposes.

Implied Motion From Form Shows Motion Aids the Perception of Global Form in Amblyopia

PurposeGlobal motion and global form perception have been found to be abnormal in the presence of amblyopia. How such deficits manifest in visual function reliant on the interactions between these two visual processing mechanisms has not been adequately explored. In the current study, we use dynamic Glass patterns (dGlass) to measure implied motion thresholds in variable external noise to investigate the local and global limitations of processing.MethodsA total of 13 amblyopes (eight strabismic and five anisometropic, mean interocular visual acuity difference 0.30 ± 0.12 logMAR) and six visually normal controls discriminated the overall implied motion of dGlass generated by presenting nine independent sets of static Glass patterns over 0.5 seconds. The orientation of dipole elements was derived from the Gaussian distribution with prescribed mean and standard deviation that served as external noise. Thresholds at varying external noise were fitted to a set of linear amplifier models that were statistically compared to investigate the contribution of local and global processing parameters.ResultsThe implied motion thresholds were higher for strabismic (4.33° ± 1.34°) compared to anisometropic (2.32° ± 0.76°) amblyopia and controls (2.28° ± 0.50°) in the no-noise condition. The multivariate ANOVA analysis showed no difference between amblyopic and control observers at the no-noise and high-noise levels (P > 0.1). The statistical comparison of nested models showed normal internal noise and sampling efficiency parameters for both strabismic and anisometropic amblyopia (PS >0.50).ConclusionsThe normal thresholds for implied motion in this study would suggest that motion aids the perception of global form cues present in dynamic Glass patterns. Our results challenge the proposed dorsal stream vulnerability in developmental disorders such as amblyopia.

The Role of Attention in Amblyopic Global Form Perception

The Role of Attention in Amblyopic Global Form Perception

Cortical correlates of amblyopia: what information is lost and why?

Amblyopia is a developmental disorder of vision resulting from abnormal binocular visual experience in childhood. Psychophysical studies in amblyopic humans and macaques show losses in basic spatial vision (acuity and contrast sensitivity), but in addition, there are extensive losses in higher order perceptual abilities. These deficient higher order abilities, such as global form and motion perception and perceptual organization, are not predictable from the loss in acuity. Neurophysiological studies of striate cortex in behaviorally characterized amblyopic macaques show that some aspects of amblyopia are reflected in the properties of single neurons, but that overall neural sensitivity far exceeds behavioral sensitivity. Therefore there is information available in the visual system that is not being used to guide visual performance. What information is lost and what mechanisms contribute to that loss? Our recent studies show that some answers can be found via population analyses at the level of striate and extrastriate cortex, and characterizing neural interactions under dichoptic viewing. Current thinking about the neural correlates of amblyopia will be discussed.

Concurrent Investigation of Global Motion and Form Processing in Amblyopia: An Equivalent Noise Approach.

Directly comparing the motion and form processing in neurologic disorders has remained difficult due to the limitations in the experimental stimulus. In the current study, motion and form processing in amblyopia was characterized using random dot stimuli in different noise levels to parse out the effect of local and global processing on motion and form perception. A total of 17 amblyopes (8 anisometropic and 9 strabismic), and 12 visually normal subjects monocularly estimated the global direction of motion and global orientation in random dot kinematograms (RDK) and Glass patterns (Glass), whose directions/orientations were drawn from normal distributions with a range of means and variances that served as external noise. Direction/orientation discrimination thresholds were measured without noise first then variance threshold was measured at the multiples of the direction/orientation threshold. The direction/orientation and variance thresholds were modelled to estimate internal noise and sampling efficiency parameters. Overall, the thresholds for Glass were higher than RDK for all subjects. The thresholds for both Glass and RDK were higher in the strabismic eyes compared with the fellow and normal eyes. On the other hand, the thresholds for anisometropic amblyopic eyes were similar to the normal eyes. The worse performance of strabismic amblyopes was best explained by relatively low sampling efficiency compared with other groups (P < 0.05). A deficit in global motion and form perception was only evident in strabismic amblyopia. Contrary to the dorsal stream deficiency hypothesis assumed in other developmental disorders, deficits were present in both motion (dorsal) and form (ventral) processing.

Visual processing in migraine.

Background Migraine is a common neurological condition that often involves differences in visual processing. These sensory processing differences provide important information about the underlying causes of the condition, and for the development of treatments. Review of psychophysical literature Psychophysical experiments have shown consistent impairments in contrast sensitivity, orientation acuity, and the perception of global form and motion. They have also established that the addition of task-irrelevant visual noise has a greater effect, and that surround suppression, masking and adaptation are all stronger in migraine. Theoretical signal processing model We propose utilising an established model of visual processing, based on signal processing theory, to account for the behavioural differences seen in migraine. This has the advantage of precision and clarity, and generating clear, falsifiable predictions. Conclusion Increased effects of noise and differences in excitation and inhibition can account for the differences in migraine visual perception. Consolidating existing research and creating a unified, defined theoretical account is needed to better understand the disorder.

From Flashes to Edges to Objects: Recovery of Local Edge Fragments Initiates Spatiotemporal Boundary Formation.

Spatiotemporal boundary formation (SBF) is the perception of illusory boundaries, global form, and global motion from spatially and temporally sparse transformations of texture elements (Shipley and Kellman, 1993a, 1994; Erlikhman and Kellman, 2015). It has been theorized that the visual system uses positions and times of element transformations to extract local oriented edge fragments, which then connect by known interpolation processes to produce larger contours and shapes in SBF. To test this theory, we created a novel display consisting of a sawtooth arrangement of elements that disappeared and reappeared sequentially. Although apparent motion along the sawtooth would be expected, with appropriate spacing and timing, the resulting percept was of a larger, moving, illusory bar. This display approximates the minimal conditions for visual perception of an oriented edge fragment from spatiotemporal information and confirms that such events may be initiating conditions in SBF. Using converging objective and subjective methods, experiments showed that edge formation in these displays was subject to a temporal integration constraint of ~80 ms between element disappearances. The experiments provide clear support for models of SBF that begin with extraction of local edge fragments, and they identify minimal conditions required for this process. We conjecture that these results reveal a link between spatiotemporal object perception and basic visual filtering. Motion energy filters have usually been studied with orientation given spatially by luminance contrast. When orientation is not given in static frames, these same motion energy filters serve as spatiotemporal edge filters, yielding local orientation from discrete element transformations over time. As numerous filters of different characteristic orientations and scales may respond to any simple SBF stimulus, we discuss the aperture and ambiguity problems that accompany this conjecture and how they might be resolved by the visual system.

Dissociations in Coherence Sensitivity Reveal Atypical Development of Cortical Visual Processing in Congenital Achromatopsia.

While basic visual functions have been described in subjects with congenital achromatopsia (ACHM), little is known about their mid- or high-level cortical visual processing. We compared midlevel cortical visual processing in ACHM subjects (n = 11) and controls (n = 20). Abilities to detect global form, global motion, and biological motion embedded in noise were tested across a range of light levels, including scotopic, in which both ACHM subjects and controls must rely on rods. Contrast sensitivity functions (CSFs) were also measured. Achromatopsia subjects showed differential impairments across tests. In scotopic conditions, global form was most impaired, while biological motion was normal. In a subset of three ACHM subjects with normal scotopic CSFs, two of the three showed global form perception worse than controls; all showed global motion comparable to controls; and strikingly, two of the three showed biological motion perception superior to controls. The cone signal appears to play a crucial role in the development of perception of global form, as in ACHM this is impaired even in scotopic conditions, in which controls also have to rely on rods, and even in ACHM subjects with no scotopic spatial vision loss. In contrast, the rod signal appears sufficient for the development of normal (or even superior) extrastriate biological motion perception. These results suggest that ACHM leads to atypical development of cortical vision, highlighting the need to better understand the potential for further reorganization of cortical visual processing following new therapies aimed at restoring cone function.

The effect of blur on cortical responses to global form and motion.

Global form and motion sensitivity undergo long development in childhood with motion sensitivity rather than form being impaired in a number of childhood disorders and both impaired in adult clinical populations. This suggests extended development and vulnerability of extrastriate cortical areas associated with global processing. However, in some developmental and clinical populations, it remains unclear to what extent impairments might reflect deficits at earlier stages of visual processing, such as reduced visual acuity and contrast sensitivity. To address this, we investigated the impact of degraded spatial vision on cortical global form and motion processing in healthy adults. Loss of high spatial frequencies was simulated using a diffuser to blur the stimuli. Participants completed behavioral and EEG tests of global form and motion perception under three levels of blur. For the behavioral tests, participants' form and motion coherence thresholds were measured using a two-alternative, forced-choice procedure. Steady-state visual evoked potentials were used to measure cortical responses to changes in the coherence of global form and motion stimuli. Both global form and global motion perception were impaired with increasing blur as measured by elevated behavioral thresholds and reduced cortical responses. However, form thresholds showed greater impairment in both behavioral and EEG measures than motion thresholds at the highest levels of blur. The results suggest that high spatial frequencies play an important role in the perception of both global form and motion but are especially significant for global form. Overall, the results reveal complex interactions between low-level factors and global visual processing, highlighting the importance of taking these factors into account when investigating extrastriate function in low vision populations.

Tilt after-effect from perception of global form from Glass Patterns

Tilt after-effect from perception of global form from Glass Patterns

Improved Visual Perception in Very Low Birth Weight Infants on Enhanced Nutrient Supply

Background: Optimal nutrient supply to very low birth weight (VLBW: BW <1,500 g) infants is important for growth and neurodevelopment. Growth restriction is common among these infants and may be associated with neurocognitive impairments. Objectives: To compare an enhanced nutrient supply to a routine supply given to VLBW infants and to evaluate the effects on visual perception of global form and motion measured by visual event-related potentials (VERP). Methods: A total of 50 VLBW infants were randomized to an intervention group that received an increased supply of energy, protein, fat, essential fatty acids, and vitamin A or a control group that received standard nutritional care. At 5 months' corrected age the infants were examined using VERP to investigate the responses to global form and motion. VERP were analysed at the first (f1) and third (f3) harmonics of the stimulus frequency. Results: Data from 31 subjects were eligible for analysis. The motion VERP responses for the f1 and f3 components were stronger in the area near the posterior midline region in the intervention group compared to the controls in the group analyses (p = 0.02 and p = 0.001, respectively). Conclusion: The results showed a more consistent response to global motion among infants receiving enhanced nutrition. The intervention may have improved visual perception of global motion.