Global Focus Research Articles

Policy responses to real world challenges associated with NEET youth: a scoping review

In the last decades, young people not in education or employment have become the focus of policy-makers worldwide, and there are high political expectations for various intervention initiatives. Despite the global focus, there is currently a lack of systemic knowledge of the factors supporting policy-making. Therefore, using scoping review methodology, a systematic literature overview of research findings in 2013–2021 on young people not in education or employment will be provided. The research revealed five categories to consider from a policy-making perspective: “NEET” as a concept, the heterogeneity of the target group, the impact of policies for young people, possible interventions, and factors influencing young people's coping strategies. Based on analysis, the target group requires applying the holistic principle where the young person is a unique person whose involvement in service creation supports the service's compliance with the actual needs of young people. To support young people, it is important to consider differences within a single social group; the interaction between the different site-based policies; young people's sense of self-perception and autonomy in entering support services; possible coping strategies and the need to provide support in a time and place-based flexible and caring environment through multidisciplinary teams. The study's results support the importance of implementation and the identification of existing opportunities of the EU's reinforced Youth Guarantee guidelines and point to possible future research topics related to the target group.

Thirty years of International Transactions in Operational Research: past, present, and future direction

AbstractThe journal “International Transactions in Operational Research” (ITOR) marks its 30th anniversary this year. This study undertakes the first bibliometrics analysis of ITOR covering the past 30 years (1994–2023). Utilizing metadata from 1835 articles published in the journal, this article evaluates ITOR’s intellectual, conceptual, and social structures. The study highlights several exciting outcomes: First, the literature publication trend shows sustained growth and increased articles’ publication and citation impacts. Second, the analysis of the intellectual structure using co‐citation analysis and text analytics identified a solid collaborative relationship with core sources in operations research and management science and applications. Third, the conceptual evaluation using the co‐occurrence of keywords as the unit of analysis identifies the thematic trends of publications in ITOR. Finally, the social structures, which focused on country collaborations and literature contributions dynamics and impacts, offer insights into future directions to maintaining or strategizing a global focus for the Journal.

Global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium

Cirrhosis, the end result of liver injury, has high mortality globally. The effect of country-level income on mortality from cirrhosis is unclear. We aimed to assess predictors of death in inpatients with cirrhosis using a global consortium focusing on cirrhosis-related and access-related variables. In this prospective observational cohort study, the CLEARED Consortium followed up inpatients with cirrhosis at 90 tertiary care hospitals in 25 countries across six continents. Consecutive patients older than 18 years who were admitted non-electively, without COVID-19 or advanced hepatocellular carcinoma, were enrolled. We ensured equitable participation by limiting enrolment to a maximum of 50 patients per site. Data were collected from patients and their medical records, and included demographic characteristics; country; disease severity (MELD-Na score); cirrhosis cause; medications used; reasons for admission; transplantation listing; cirrhosis-related history in the past 6 months; and clinical course and management while hospitalised and for 30 days post discharge. Primary outcomes were death and receipt of liver transplant during index hospitalisation or within 30 days post discharge. Sites were surveyed regarding availability of and access to diagnostic and treatment services. Outcomes were compared by country income level of participating sites, defined according to World Bank income classifications (high-income countries [HICs], upper-middle-income countries [UMICs], and low-income or lower-middle-income countries [LICs or LMICs]). Multivariable models controlling for demographic variables, disease cause, and disease severity were used to analyse the odds of each outcome associated with variables of interest. Patients were recruited between Nov 5, 2021, and Aug 31, 2022. Complete inpatient data were obtained for 3884 patients (mean age 55·9 years [SD 13·3]; 2493 (64·2%) men and 1391 (35·8%) women; 1413 [36·4%] from HICs, 1757 [45·2%] from UMICs, and 714 [18·4%] from LICs or LMICs), with 410 lost to follow-up within 30 days after hospital discharge. The number of patients who died while hospitalised was 110 (7·8%) of 1413 in HICs, 182 (10·4%) of 1757 in UMICs, and 158 (22·1%) of 714 in LICs and LMICs (p<0·0001), and within 30 days post discharge these values were 179 (14·4%) of 1244 in HICs, 267 (17·2%) of 1556 in UMICs, and 204 (30·3%) of 674 in LICs and LMICs (p<0·0001). Compared with patients from HICs, increased risk of death during hospitalisation was found for patients from UMICs (adjusted odds ratio [aOR] 2·14 [95% CI 1·61-2·84]) and from LICs or LMICs (2·54 [1·82-3·54]), in addition to increased risk of death within 30 days post discharge (1·95 [1·44-2·65] in UMICs and 1·84 [1·24-2·72] in LICs or LMICs). Receipt of a liver transplant was recorded in 59 (4·2%) of 1413 patients from HICs, 28 (1·6%) of 1757 from UMICs (aOR 0·41 [95% CI 0·24-0·69] vs HICs), and 14 (2·0%) of 714 from LICs and LMICs (0·21 [0·10-0·41] vs HICs) during index hospitalisation (p<0·0001), and in 105 (9·2%) of 1137 patients from HICs, 55 (4·0%) of 1372 from UMICs (0·58 [0·39-0·85] vs HICs), and 16 (3·1%) of 509 from LICs or LMICs (0·21 [0·11-0·40] vs HICs) by 30 days post discharge (p<0·0001). Site survey results showed that access to important medications (rifaximin, albumin, and terlipressin) and interventions (emergency endoscopy, liver transplantation, intensive care, and palliative care) varied geographically. Inpatients with cirrhosis in LICs, LMICs, or UMICs have significantly higher mortality than inpatients in HICs independent of medical risk factors, and this might be due to disparities in access to essential diagnostic and treatment services. These results should encourage researchers and policy makers to consider access to services and medications when evaluating cirrhosis-related outcomes. National Institutes of Health and US Department of Veterans Affairs.

Global research trends and focus on the link between colorectal cancer and gut flora: a bibliometric analysis from 2001 to 2021.

Colorectal cancer (CRC) is a highly prevalent cancer, and the global healthcare system bears a significant burden due to its incidence. Modulating the gut microbiota is a promising approach to enhance the efficacy of CRC treatment and reduce its adverse effects. The causal relationship between specific microorganisms' presence and CRC development has been widely validated. However, few studies have investigated this relationship using bibliometric methods. Therefore, this study analyzed the research hotspots and trends in human gut microbiology and CRC over the last two decades from a bibliometric perspective. The study aims to provide novel insights into basic and clinical research in this field. The articles and reviews on gut microbiota in CRC were obtained from the Web of Science Core Collection (WOSCC) on November 2, 2022. CiteSpace and VOSviewer were used to conduct the bibliometric and knowledge-map analysis. A total of 2,707 publications were obtained, with a rapid increase in the number of publications since 2015. The United States and China are the main contributors in this field and have established a network of partnerships in several countries. 414 academic journals have published articles on this topic. The author with the highest number of publications is Jun Yu from the Chinese University of Hong Kong. In addition to "intestinal flora" and "colorectal cancer," high frequency terms in the keyword co-occurrence network analysis included inflammatory bowel disease, Fusobacterium nucleatum, inflammation, long-chain fatty acids, ulcerative colitis, bile acids, and resistant starch. Analysis of keyword trends using burst testing revealed that biomarkers, abnormal crypt foci, bifidobacteria, β-glucuronidase, short-chain fatty acids, bile acids, and DNA methylation are at the forefront of research in this area. The findings of this study provide a bibliometric analysis and visualization of the key research areas in gut microbiota and CRC over the past 20 years. The results suggest that the role of gut microbiota in CRC and its underlying mechanisms should be closely monitored, particularly in the areas of biomarkers, metabolic pathways, and DNA methylation, which may emerge as hot topics in this field.

Transformation of the global governance in the cocoa sector with three characteristics: Diversification, flexibilization, and coordination

The cocoa sector has continued its global efforts to address various environmental and social issues. This research aims to unpack characteristics of the global cocoa governance focusing on global actors, rules, and agendas through content analysis with global documents related to the cocoa sector. This research includes the 60 year time frame from 1962, the year of establishment of Intergovernmental Cocoa Organization, to 2021. The results indicate a transition in global cocoa governance with three characteristics: diversification, flexibilization, and coordination. First, the actors and agendas in the cocoa sector were diversified throughout the study period. Starting from the early 2000s, private actors emerged and actively participated in forming global cocoa agendas and suggesting solutions to cocoa-related problems. Accordingly, diverse actors have handled diverse agendas. Second, the global cocoa rules were softened and flexibilized. Until the 2000s, treaties among countries controlled the global cocoa industry. Recently-introduced soft rules from 2012 enabled diverse issues to be addressed and facilitated the participation of various actors. Third, coordination between the international and state levels was emphasized in agreements and declarations. The inclusion of varied actors and agendas necessitated aligning efforts for improving global cocoa governance.

The Block: A catalyst for ongoing innovation

This paper will contribute to our understanding of the Block, its pedagogical rationale and value, and explain why, apart from pandemic conditions, these might constitute a compelling alternative to traditional academic calendars. Current research highlights the need for further research on the nature of the Block, driven by an increased global focus on student outcomes and retention in Higher Education. This paper offers five case studies from institutions that have adopted a version of the Block at some time over the last 50 years. The authors seek to define the features that comprise block courses whereas the nature and functionality distinguish blocks from other intensive formats. A survey of the limited literature on this topic was based on theoretical underpinnings offered by one-course-at-a-time delivery, scholarship of teaching and learning on compressed education, and experiential learning. Using the research question, “Other than scheduling alternatives, what does the block offer HE institutions?”, this project uses research that is qualitative in nature drawing on a controlled comparison of case studies which enables a cross-institutional evaluation. The case studies explain why each institution adopted the Block, how these schedules work, and discusses the challenges and affordances of teaching in this intensive format. First findings of this cross-institutional exploration suggest that blocks are unique in their delivery, often experiential in nature, and effective in their outcomes. The various versions of the Block described within, provide ongoing transformative models of teaching philosophy, curriculum, student success, and more.

Impact of COVID-19 pandemic and anti-pandemic measures on tuberculosis, viral hepatitis, HIV/AIDS and malaria-A systematic review.

COVID-19 pandemic puts an enormous strain on health care systems worldwide and may have a detrimental effect on prevention, treatment and outcomes of tuberculosis (TB), viral hepatitis, HIV/AIDS and malaria, whose ending is part of the United Nations 2030 Agenda for Sustainable Development. We conducted a systematic review of scientific and grey literature in order to collect wide-ranging evidence with emphasis on quantification of the projected and actual indirect impacts of COVID-19 on the four infectious diseases with a global focus. We followed PRISMA guidelines and the protocol registered for malaria (CRD42021234974). We searched PubMed, Scopus, preView (last search: January 13, 2021) and websites of main (medical) societies and leading NGOs related to each of the four considered infectious diseases. From modelling studies, we identified the most impactful disruptions; from surveys and other quantitative studies (based e.g. on surveillance or program data), we assessed the actual size of the disruptions. The identified modelling studies warned about under-diagnosis (TB), anti-retroviral therapy interruption/decrease in viral load suppression (HIV), disruptions of insecticide-treated nets (ITN) distribution and access to effective treatment (malaria), and treatment delays and vaccination interruptions (viral hepatitis). The reported disruptions were very heterogeneous both between and within countries. If observed at several points in time, the initial drops (partly dramatic, e.g. TB notifications/cases, or HIV testing volumes decreased up to -80%) were followed by a gradual recovery. However, the often-missing assessment of the changes against the usual pre-pandemic fluctuations hampered the interpretation of less severe ones. Given the recurring waves of the pandemic and the unknown mid- to long-term effects of adaptation and normalisation, the real consequences for the fight against leading infectious diseases will only manifest over the coming years.

Synthesis of Existent Oncology Curricula for Primary Care Providers: A Scoping Review With a Global Equity Lens

Global increases in cancer, coupled with a shortage of cancer specialists, has led to an increasing role for primary care providers (PCP) in cancer care. This review aimed to examine all extant cancer curricula for PCPs and to analyze the motivations for curriculum development. A comprehensive literature search was conducted from inception to October 13, 2021, with no language restrictions. The initial search yielded 11,162 articles and 10,902 articles underwent title and abstract review. After full-text review, 139 articles were included. Numeric and thematic analyses were conducted and education programs were evaluated using Bloom's taxonomy. Most curricula were developed in high-income countries (HICs), with 58% in the United States. Cancer-specific curricula focused on HIC priority cancers, such as skin/melanoma, and did not represent the global cancer burden. Most (80%) curricula were developed for staff physicians and 73% focused on cancer screening. More than half (57%) of programs were delivered in person, with a shift toward online delivery over time. Less than half (46%) of programs were codeveloped with PCPs and 34% did not involve PCPs in the program design and development. Curricula were primarily developed to improve cancer knowledge, and 72 studies assessed multiple outcome measures. No studies included the top two levels of Bloom's taxonomy of learning (evaluating; creating). To our knowledge, this is the first review to assess the current state of cancer curricula for PCPs with a global focus. This review shows that extant curricula are primarily developed in HICs, do not represent the global cancer burden, and focus on cancer screening. This review lays a foundation to advance the cocreation of curricula that are aligned to the global cancer burden.

Epigallocatechin-3-gallate/mineralization precursors co-delivery hollow mesoporous nanosystem for synergistic manipulation of dentin exposure.

As a global public health focus, oral health plays a vital role in facilitating overall health. Defected teeth characterized by exposure of dentin generally increase the risk of aggravating oral diseases. The exposed dentinal tubules provide channels for irritants and bacterial invasion, leading to dentin hypersensitivity and even pulp inflammation. Cariogenic bacterial adhesion and biofilm formation on dentin are responsible for tooth demineralization and caries. It remains a clinical challenge to achieve the integration of tubule occlusion, collagen mineralization, and antibiofilm functions for managing exposed dentin. To address this issue, an epigallocatechin-3-gallate (EGCG) and poly(allylamine)-stabilized amorphous calcium phosphate (PAH-ACP) co-delivery hollow mesoporous silica (HMS) nanosystem (E/PA@HMS) was herein developed. The application of E/PA@HMS effectively occluded the dentinal tubules with acid- and abrasion-resistant stability and inhibited the biofilm formation of Streptococcus mutans. Intrafibrillar mineralization of collagen fibrils and remineralization of demineralized dentin were induced by E/PA@HMS. The odontogenic differentiation and mineralization of dental pulp cells with high biocompatibility were also promoted. Animal experiments showed that E/PA@HMS durably sealed the tubules and inhibited biofilm growth up to 14 days. Thus, the development of the E/PA@HMS nanosystem provides promising benefits for protecting exposed dentin through the coordinated manipulation of dentin caries and hypersensitivity.

Intelligent Multi-Criteria Decision Support for Renovation Solutions for a Building Based on Emotion Recognition by Applying the COPRAS Method and BIM Integration

With accelerating climate change and the urgent need to cut carbon emissions, global focus has turned to the existing building stock and its renovation. Sustainable renovation helps to achieve better energy performance and gain wider sustainability benefits, such as increased value of a building, improved indoor and outdoor comfort, reduced carbon emissions, and the higher satisfaction and better emotional state of inhabitants. Numerous systems and tools have been developed worldwide to assist with decision making in the choice of preferred modernisation scenarios and alternatives. However, social aspects are often neglected in the existing systems, and emotions of inhabitants are rarely analysed. To close this gap, the present study proposes an innovative decision-making framework for sustainable renovation solutions, based on emotion recognition. The framework makes it possible to assess various renovation alternatives against sustainability criteria and real-time measurements of the emotional states of inhabitants. Based on the proposed framework, an intelligent multi-criteria decision support system was developed by integrating COPRAS and the facial action coding system, the method of automatic facial expression recognition, and the continuous calibration and participant methods. The system was tested in the case study of renovation solutions for a building located in Ukraine. The research results revealed that the proposed renovation solutions had a positive impact on the emotional state of inhabitants, especially when visual materials such as drawings were presented. Some case studies were analysed together with the application of decision system tools and building information modelling (BIM) subsystem integration as a multidiscipline application of various applied sciences for representation and data analysis. The authors of this research have been analysing human emotional, affective and physiological states for many years and collected over a billion of these data in Vilnius city during the H2020 ROCK, SAVAS and BIM4REN projects. Data acquired during measurements in Vilnius were used to determine correlations and trends for the case study. The proposed methodology and findings of the study can be useful for researchers who use the evaluation and analysis of human emotions when there is a need to choose appropriate renovation measures or find alternative solutions.

A Scoping Review on Resources, Tools, and Programs to Support Women's Leadership in Global Health: What Is Available, What Works, and How Do We Know?

The unequal representation of women in global health leadership is a prevalent issue laterally across global health fields and vertically down experience levels. Although women compose much of the workforce, gender-based barriers prevent female talent from filling their appropriate leadership roles, which funnels unique expertise and problem-solving skills on a diversity of health topics out of positions of leadership. Currently, many calls to action have been proposed to raise awareness of the lack of women's global health leadership, with Women in Global Health as one of the more prominent movements. This paper evaluates how the priorities and strategies for leadership training and development set forth by such movements have changed the landscape of available programs and resources for women in global health, based on availability, success, and evaluation. This manuscript maps existing programs and resources that support women's leadership in global health and describes available evaluations and documented outcomes. We used a dual approach of a peer-reviewed and gray literature search to build a comprehensive list of existing programs and resources designed to support women's leadership in global health. Out of 54 items included for full-text review and 22 gray literature items screened for inclusion, a total of 31 resources were processed in the final extraction. We used descriptive quantitative analysis for categorical and binary variables, while qualitative data from evaluations were analyzed for outcomes. Resources were in the form of conferences, supplemental resources to conferences, certificate programs, coursework, stand-alone documents, single-focus programs, and mostly multicomponent programs. Most resources did not have a global health focus area, and a third of the total resources identified women first authors from predominantly high-income countries. About half of the resources mention mentorship and networking as activities incorporated as part of the resource. Over half of the resources did not have a target audience, and most resources were free to users.While there is a lack of consistent and meaningful evaluation of the resources, the available captured metrics of success were described as the number of career-advancing opportunities after using the resources. Examples of opportunities include enrollment in graduate school, receiving academic promotions, participating in internships, presenting at conferences, and publications. While the supply of existing programming and resources to advance women's leadership in the global health field is limited in terms of quantity, it is rich in diverse formats, content, and implementation. This scoping review supports the notion that empowered female leadership in global health requires a complementary support system that encourages the unique needs and talents of female leaders. Such a support system needs inclusive targeting regardless of experience level, academic degree, or location. Furthermore, evaluations of resources will be critical in maintaining meaningful interventions that effectively dismantle the infrastructures that continue to limit the success of women leaders in global health.

The Legal Duty of States to Cooperate in the Fight Against Pandemic Disease under the International Health Regulations

Abstract The paper outlines the contemporary legal framework of global health focusing on the legal duty of States to cooperate in the surveillance, prevention, and control of epidemic and pandemic disease. The paper details, in particular, the content and nature of States’ duty to cooperate under the International Health Regulations – the primary international legal instrument governing the global response to such events. It also examines the role of the World Health Organization and other UN bodies in fostering cooperation between States in the fight against epidemics and pandemics.

Environmental implication of international migration on high- and middle-income countries: A comparative analysis

In this paper, we researched the implication of international migration and pollution on environmental development of the selected countries which we classified as middle- and upper-income countries. Maintaining good environmental performance while keeping pollution at minimum level amidst international migration has being the global focus towards climate goal. On this premises, this study examines the relationship between international migration and carbon dioxide emission (CO2). Scientific approaches (random-effects model and Driscoll-Kraay standard error estimator) with panel data for the period from 2010 to 2019 are adopted for indepth analysis of the selected countries. The findings according to random-effects model/Driscoll-Kraay standard error estimator suggest the incresae of CO2 due to increase in international migration for the case of middle-income countries. Also, a decrease in CO2 due to increase in international migration is found for high-income countries. Following our main findings, as a function of CO2 emission, we recommend to take identity of people who migrate into consideration for both economics and environment policy. On the other hand, policies should be based on mitigating the negative impact of international migration and economic growth for the middle-income countries. Moreover, environmentally friendly growth technologies are suggested.

A methodological framework for ranking communicable and non-communicable diseases due to climate change – A focus on Ireland

There is currently a significant global focus from the public health community on addressing climate-related public health issues. Globally we are witnessing geological shifts, extreme weather events, and the associated incidents that may have a significant human health impact. These include unseasonable weather, heavy rainfall, global sea-level rise and flooding, droughts, tornados, hurricanes, and wildfires. Climate change can have a direct and indirect health impact. The global challenge of climate change requires global preparedness for potential human health effects due to climate change, including vigilance for diseases carried by vectors, foodborne and waterborne diseases, deteriorated air quality, heat stress, mental health, and potential disasters. Therefore, it is essential to identify and prioritise the consequences of climate change to become future-ready. This proposed methodological framework aimed to develop an innovative modelling method using the ‘Disability-Adjusted Life Year (DALY)’, to rank potential direct and indirect human health impacts (communicable and non-communicable diseases) of climate change. This approach aims to ensure food safety, including water, in the wake of climate change. The novelty of the research will come from developing models with spatial mapping (Geographic Information System or GIS), which will also consider the influence of climatic variables, geographical differences in exposure and vulnerability and regulatory control on feed/food quality and abundance, range, growth, and survival of selected microorganisms. In addition, the outcome will identify and assess emerging modelling techniques and computational-efficient tools to overcome current limitations in climate change research on human health and food safety and to understand uncertainty propagation using the Monte Carlo simulation method for future climate change scenarios. It is envisaged that this research work will contribute significantly to developing a lasting network and critical mass on a national scale. It will also provide a template to implement from a core centre of excellence in other jurisdictions.

Building a Timeline for LGBTQ+ Global Cinemas (1910–2019): Movie Production Trends from a Collaborative Internet Cinema Database

Building a Timeline for LGBTQ+ Global Cinemas (1910–2019): Movie Production Trends from a Collaborative Internet Cinema Database

Preparing Students for Post-COVID Nursing Careers: The Value of International Clinical Placements

Prior to the coronavirus disease 2019 (COVID-19) pandemic, international clinical placements (ICPs) for nursing students were used to build cultural humility and global awareness. This study explored the influence of ICPs on nursing students' career planning and views of the nursing role; the findings were considered against the evolving pandemic context. A qualitative, descriptive longitudinal study was conducted with 25 preregistration nursing students who participated in an international placement. Semistructured individual interview data were examined using thematic analysis. Participants were interested in patient equity and empowerment, high acuity and variety, health policy, and primary care. Participants developed resilience and nursing confidence. They saw the effects of poor health equity and health policy decisions on population health. ICPs expanded participants' understanding of global interconnectedness and also identified new career possibilities. Postpandemic, nursing education should continue to maintain a global focus on health. [J Nurs Educ. 2023;62(4):207-214.].

Assessment of Water, Sanitation and Hygiene (WaSH) Status and Water Qualities Using Physicochemical and Bacteriological Indices at Automobile Spare-Parts Markets in Benin City, Nigeria

Global focus is currently on water, sanitation and hygiene (WaSH) due its public health and environmental significance. The aim of this study was to investigate the Water, Sanitation and Hygiene status of Uwelu and Evbareke spare parts markets in Benin City. Questionnaires were administered to evaluate the WaSH status of the markets. Physicochemical and bacteriological qualities of borehole water samples at the spare parts markets were investigated adopting standard analytical procedures and pour plate techniques respectively. Findings revealed that the pH values of Uwelu and Evbareke ranged from 5.28 - 5.29 and 4.78 - 5.11 respectively. The highest concentration of chloride was observed in Evbareke samples (49.70 mg/l) while that of nitrate and BOD5 were 2.06mg/l in Evbareke and 0.88mg/l in Uwelu respectively. Comparing the value recorded in this study with WHO recommended standard which is 0.01-0.015mg/l, the mean value for Evbareke spare-parts market exceeded the recommended limit for lead at 0.02±0.025 mg/l. Total heterotrophic bacterial counts ranged from 3.1 - 4.4 × 102 cfu/ml and 3.1 - 2.9 × 102 cfu/ml (Evbareke). The total coliform counts in Uwelu and Evbareke spare parts markets ranged from 4 - 9 MPN/ml and 0 - 20 MPN/ml. The array of bacteria isolates was Escherichia coli, Enterobacter spp. Klebsiella sp. and Staphylococcus spp. Findings from this study suggest the urgent need to improve water safety, sanitation and hygiene policy of these studied popular automobile spare-parts markets in Benin City, Edo State.

Carpe DM: The First Global Diabetes Targets.

<h3>Key Messages</h3> Diabetes control is hampered by global inequities in care, which the new global diabetes targets aim to address. There are notable similarities and differences between the diabetes targets and the widely adopted HIV targets. These targets, combined with concrete operational plans, will help the global community focus efforts toward achieving global diabetes control.

Effects of vaccines on clinical characteristics of convalescent adult patients infected with SARS-CoV-2 Omicron variant: A retrospective study.

The protective effect of SARS-CoV-2 vaccines has become a global focus due to Omicron variant pandemic. The effects of various SARS-CoV-2 vaccines are diverse. However, studies on the effect of domestic vaccines on clinical characteristics in convalescent adult patients infected with the Omicron variant are lacking. In this retrospective, single-center cohort study, the effect of three domestic vaccines on clinical characteristics of convalescent adult patients infected with the Omicron variant was investigated in the initial largest outbreak of the Omicron variant infection between January and February 2022 in Tianjin, China. The primary endpoint was COVID-19 severity and the secondary endpoints were re-positive results on nucleic acid tests, liver and kidney function, and inflammation levels during recovery. A total of 320 adult patients infected with the Omicron variant were enrolled, including 296 post-vaccination and 24 unvaccinated patients. The median age of the unvaccinated patients was higher than that of vaccinated patients, but no significant difference was detected in the sex composition ratio between the different groups. Binary logistic regression results suggested that Sinopharm and Sinovac vaccine was an independent protective factor for relieving the severity of the Omicron variant infection. Regrettably, the vaccines did not showed any protective effect on the liver and kidney function of convalescent adult patients. Three domestic vaccines significantly relieved inflammation and increased the SARS-CoV-2-specific antibody levels. Furthermore, Sinovac and CanSino vaccines had a better immune stimulation effect on increasing T lymphocytes levels in convalescent adult patients. In addition, three domestic vaccines have protective effects on preventing re-detectable positive (RP) result in convalescent adult patients. Although the three domestic vaccines cannot prevent the infection of the Omicron variant, it has a significant protective effect in adult patients. This study supports the policy of accelerating to vaccination worldwide combat the evolving and mutating SARS-CoV-2. Omicron spreads faster and might escape antibodies more readily than previous variants, increasing the cases of reinfection and breakthrough infections in vaccinated people. Although vaccinated people are likely to have a much lower risk of severe disease from Omicron infection, many issues still need to be considered. Concerns about lower vaccine efficacy because of new variants might have changed our understanding of the COVID-19 endgame, disabusing the world of the notion that global vaccination is by itself adequate for controlling SARS-CoV-2 infection. The current data showed that vaccination with three domestic SARS-CoV-2 vaccines alleviates the disease severity of adult patients with COVID-19, reduces the inflammation level and the RP rate of convalescent adult patients, and enhances body's defense against the virus in convalescent adult patients. Moreover, our study has highlighted that a combination prevention approach of vaccination and public health measures would be an effective strategy.

Assessment of Malnutrition among Children Presenting in a Nutrition Center in Gimbichu, Ethiopia

Nowadays, Ethiopia has several problems affecting children below 5 years of age, resulting in low life expectancies. Our group carried out a study to calculate the presence of malnutrition as wasting, stunting underweight, and BMI-for-age in children presenting in a nutrition center in a rural Ethiopian village in the Oromia region according to WHO guidelines. Our results demonstrated that they had moderate chronic malnutrition or stunting from 1 to 2 years of age, affecting their life, their parents, their community/household, and their country. In our viewpoint, the solution for this situation will require a global focus on several levels, including individual, family, community, and country, the last being with the help of new health policies focused on short-, medium-, and long-term strategies with multi- and interdisciplinary approaches.