In this paper, we consider an initial value problem of inhomogeneous heat conducting magnetohydrodynamic equations in R3. Through some time-weighted a priori estimates, we prove the global existence of strong solution provided that (‖ρ0u0‖L22+‖b0‖L22)(‖∇u0‖L22+‖∇b0‖L22) is suitably small, which extends the corresponding Zhong's results [16,17] to the whole space R3. Furthermore, we also derive the algebraic decay estimates of the solution.