Microplastic contamination in aquatic ecosystems poses a global environmental challenge, with local variations requiring focused investigations. This study examines the prevalence, characteristics, and ecological implications of microplastics in Xiamen Bay sediments, providing insights into the potential risks for both the environment and human health. The analysis encompasses spatial and temporal distribution patterns, ecological impacts on sediment biota, and pathways of human exposure. Key considerations for human health risk assessment are identified, considering particle characteristics, exposure levels, and vulnerable populations. The study concludes by emphasizing the importance of interdisciplinary collaboration in addressing these challenges and proposes strategies for mitigating the impact of microplastic contamination in Xiamen Bay.