Event Abstract Back to Event Laminar-, event-, and state-dependent population coding in the auditory cortex The laminar architecture of neocortex is likely an important key to its function. However, it is still unclear 1) how population activity across cortical layers orchestrates to process signals, 2) how spatiotemporal patterns evoked by sensory signals differ from internally generated ones, and 3) how global brain states affect neuronal activity in cortical microcircuits. To address these issues, we combined juxtacellular method for morphological identification of single neurons with large-scale extracellular recordings in both urethane-anesthetized and head-restrained unanesthetized rats. Based on >1500 neurons including morphologically identified pyramidal cells (PCs) in the auditory cortex, we investigated: 1) laminar organization of auditory information processing; 2) similarities and differences between auditory evoked responses and spontaneous activity; and 3) state-dependence of spontaneous activity across cortical layers. We found that; 1) strategies of neuronal population coding are different across layers. For example, both spectral and temporal stimuli were sparsely encoded in population of layer (L) 2/3 PCs, but densely in larger L5 PCs. Neuronal Correlations in L2/3 are local but stronger, compared with L5; 2) spatiotemporal patterns differ between auditory evoked responses and internally generated ‘up-states’ in their laminar profile. Although evoked activity propagates from thalamic recipient layers to others, up-state spreads from deeper toward superficial layers; and 3) spontaneous activity of superficial pyramidal cells is suppressed during desynchronized states. In conclusion, these results suggest that distinct spatiotemporal patterns of activity in the sensory cortex might allow downstream structures to distinguish sensory responses from internally generated activity. This work is supported by NIH Grants MH073245, the Alfred P Solon Foundation (KDH), Japan Society for the Promotion of Science Postdoctral Fellowships for Research Abroad and the Sound Technology Promotion Foundation (SS). Conference: Computational and systems neuroscience 2009, Salt Lake City, UT, United States, 26 Feb - 3 Mar, 2009. Presentation Type: Poster Presentation Topic: Poster Presentations Citation: (2009). Laminar-, event-, and state-dependent population coding in the auditory cortex. Front. Syst. Neurosci. Conference Abstract: Computational and systems neuroscience 2009. doi: 10.3389/conf.neuro.06.2009.03.037 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Jan 2009; Published Online: 30 Jan 2009. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Google Google Scholar PubMed Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.