To address the issue of interception, maneuvering, and precise guidance during the final stage of gliding flight, a study was conducted on the design of integrated maneuvering and guidance using a spiral trajectory as the focus. Firstly, the spiral trajectory was decomposed into an optimal reference trajectory considering the glide angle constraint and a relative motion trajectory. Then, virtual circular moving targets were introduced to meet the requirements of spiral maneuvering and virtual trajectory moving targets were introduced to ensure trajectory convergence, based on the task division of different flight stages. Finally, the guidance rate of the reference trajectory was designed based on optimal control theory, and the guidance rate of the spiral maneuver was designed based on pure proportional guidance. Simulation results show that this guidance method can enable the vehicle to perform active spiral maneuvers, and control the landing deviation and impact angle deviation to within 2.5 m and 1 degree, respectively.