This study focuses on the multi-objective optimization of a switchable Suspended Particle Device (SPD) vacuum glazing system to reduce energy use while ensuring thermal and visual comfort in schools located in arid desert environments. A detailed synergy analysis was performed on a representative floor from three school classroom typologies, comparing suspended particle device vacuum glazing in its OFF and ON states against conventional double-glazing with air gaps windows. This analysis employed an advanced simulation framework integrating Rhino-Grasshopper with Open Studio Model, Colibri 2.0, and Design Explorer2 software to evaluate energy consumption, Adaptive Comfort Percentage (ACP), and Useful Daylight Illuminance (UDI). Thermal comfort varied across typologies and orientations, with the atrium with skylight typology frequently meeting or approaching the 80% Adaptive Comfort Percentage benchmark. However, the southern and eastern classrooms in the enclosed atrium with clerestory typology did not exceed a 39% adaptive comfort percentage. The comprehensive parametric and multi-objective optimization simulation revealed that suspended particle device vacuum glazing in its 'OFF' state did not fulfill the UDI300lux-1000lux criteria across all typologies, even with maximal Window to Wall Ratio (WWR) and skylight ratio (SR). However, the enclosed atrium with clerestory, integrating SPD vacuum glazing with a 40% Window to Wall Ratio configuration, emerged as particularly effective in achieving optimal useful daylight illuminance distribution, minimizing energy consumption, and ensuring satisfactory adaptive comfort percentage across various orientations. These findings underscore the potential of multi-objective optimization of suspended particle device vacuum glazing, combined with strategic Window to Wall Ratio adjustments, as a viable alternative to traditional glazing systems in hot desert climates. The adaptability of suspended particle device vacuum glazing highlights its significant potential for achieving thermal comfort, enhancing sustainable architectural design, and improving energy efficiency in educational buildings within extreme climate zones.