Event Abstract Back to Event Endogenous and Exogenous Chemosensitivity of Neurons in the Mediodorsal Prefrontal Cortex Bernadett Nagy1*, Szilard Papp1, Gábor Takács1, Csaba Szalay1, Dora Keresztes1, Livia Nemeth1, Barnabas Hideg1, Bence Farkas1, Timea Csulak1, Miklós Rabai1 and Zoltan Karadi1 1 University of Pecs, Institute of Physiology and Neurophysiology Research Group , Hungary The mediodorsal prefrontal cortex (mdPFC), a major constituent of the forebrain limbic circuitry, plays important roles in the central regulation of feeding. Little is known, however, about the complex chemosensitivity of neurons located in this area. The purpose of our study, therefore, was to elucidate neurochemical properties and taste responsiveness of mdPFC neurons. Particular emphasis was made on their dopamine (DA) sensitivity and participation in the forebrain glucose-monitoring (GM) neural network. To do so, extracellular single neuron activity of the mdPFC of male Wistar rats was recorded by means of tungsten wire multibarreled glass microelectrodes during microelectrophoretic drug administrations and gustatory stimulations. One third of all neurons tested displayed DA responsiveness, inhibitory and excitatory firing rate changes were recorded in the same proportion. In several cases, by the application of specific DA antagonists, D1- and D2-receptor sensitivities were also identified. Appx. fifth of the neurons tested changed in activity in response to the microelectrophoretic application of D-glucose, i.e., were found to be part of the forebrain GM network. Fourty percent of these cells displayed facilitation and 60 % inhibition to the glucose administration. More than the fifth of all neurons changed in firing rate, the majority showed excitation, in response to microiontophoretically applied noradrenaline. Gustatory stimulations elicited activity changes in one third of the mdPFC neurons. These data indicate that both endogenous and exogenous chemosensory signals converge in the mdPFC. By processing such complex chemosensory information, neurons here - especially the GM ones - appear to play significant role in the central feeding control. Supported by: Health Care Scientific Council (ETT 315/2006), NKTH-RET-008/2005 MEDIPOLIS and HAS Conference: 12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009. Presentation Type: Poster Presentation Topic: Homeostatic regulatory mechanisms Citation: Nagy B, Papp S, Takács G, Szalay C, Keresztes D, Nemeth L, Hideg B, Farkas B, Csulak T, Rabai M and Karadi Z (2009). Endogenous and Exogenous Chemosensitivity of Neurons in the Mediodorsal Prefrontal Cortex. Front. Syst. Neurosci. Conference Abstract: 12th Meeting of the Hungarian Neuroscience Society. doi: 10.3389/conf.neuro.01.2009.04.016 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 25 Feb 2009; Published Online: 25 Feb 2009. * Correspondence: Bernadett Nagy, University of Pecs, Institute of Physiology and Neurophysiology Research Group, Pecs, Hungary, bernadett.nagy@aok.pte.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Bernadett Nagy Szilard Papp Gábor Takács Csaba Szalay Dora Keresztes Livia Nemeth Barnabas Hideg Bence Farkas Timea Csulak Miklós Rabai Zoltan Karadi Google Bernadett Nagy Szilard Papp Gábor Takács Csaba Szalay Dora Keresztes Livia Nemeth Barnabas Hideg Bence Farkas Timea Csulak Miklós Rabai Zoltan Karadi Google Scholar Bernadett Nagy Szilard Papp Gábor Takács Csaba Szalay Dora Keresztes Livia Nemeth Barnabas Hideg Bence Farkas Timea Csulak Miklós Rabai Zoltan Karadi PubMed Bernadett Nagy Szilard Papp Gábor Takács Csaba Szalay Dora Keresztes Livia Nemeth Barnabas Hideg Bence Farkas Timea Csulak Miklós Rabai Zoltan Karadi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.