This paper demonstrates the suitability of Prompt Gamma Activation Analysis (PGAA) technique for the compositional study of ancient glass finds, illustrating this idea by presenting and commenting the chemical composition of 41 Roman glass fragments discovered in archaeological excavations at Tomis, Histria, and Beidaud, Romania. According to typological and stratigraphic criteria, most finds were dated to the 1st-4th centuries AD. The PGAA measurements were performed at the Budapest Neutron Centre (BNC), Hungary. Regardless of their color (or the lack of it), most of the analyzed vitreous items have compositional traits often encountered in coeval glass artefacts discovered at various sites all over the Roman Empire. The sample set turned out to include several examples of Foy Série 2.1 and a single HIMT glass item, in agreement with the later chronological attribution of the corresponding fragments. This study provides some information about the chemistry of the Roman glass finds unearthed during the archaeological research performed in the region of the western Black Sea coast.