Glandular Cysts Research Articles

The glandular cyst, a polypoid lesion of the gastric mucosa (author's transl)

Confusion in the nomenclature of gastric polyps and the resulting uncertainties regarding prognosis and treatment have made a new classification necessary, consisting of focal hyperplasia, polyp of manifold aetiology, adenoma, and benign hyperplasiogenic polyp, the latter the most common one, found only in the stomach. But 110 cases of polypoid mucosal changes could not be classified. These "polyps" grow to be at most 8 mm in diameter and are characterized histologically by non-inflammatory cysts of varying size located within the intact fundal glands. Possible causes are hamartoma or functional secretory disorders. These glandular cysts have not previously been described. They do not fit the pattern of cystic gastritis. The clinical significance lies in the differentiation from gastric polyposis.

STUDIES ON EXPERIMENTAL FORMATION OF OVARIAN TUMORS

The histogenetic process of experimental ovarian tumors induced by a chemically carcinogenic substance, 9, 10-dimethyl-1, 2-benzanthracene (DMBA) in rats was studied. Morphologically, the induced tumors can be classified into two groups : Adenocarcinoma and sarcoma. A particular pattern of histogenetic process in these tumors was evidenced by killing and following these animals at staged intervals from the initiation of the experiment. When treated with DMBA, an inflammatory change occurred around the region of a silk thread insertion; and subsequently, connective tissues proliferated. In the following stages, a layer of epithelial cells which constitutes glandular cysts of various sizes, on one hand and interstitial connective tissue on the other, proliferated around them, presenting the findings of fibroadenoma. This fibroadenoma provided a basic type from which two different histogenetic processes bifurcated. In one direction, cystic components dominated and proceeded toward adenocarcinoma, and in the other connective tissue proliferation prevailed to form a sarcoma type. Between the two of them, the process toward adenocarcinoma is of much interest because of its incidence clinically; and it was found that inclusion cysts appeared to play an important role in the developmental process, which should be of special interest when compared with various reports on the histogenesis of human adenocarcinoma.

A method for experimental, penetrating gastric and duodenal ulcers in rats. Observations on normal healing.

A new and simple method of producing gastric (antral and fundic) and duodenal ulcers in rats by the topical application of acetic acid to the serosal surface is described. Three to 5 days after treatment, clearly defined, deep, round or oval ulcers, penetrating into the adjacent organs (mainly liver), appeared in the mucosal area corresponding to the treated area. The fundic and duodenal ulcers gradually diminished in size within 10–60 days, and, in all cases, were completely healed after 80 days, although the regenerated epithelium was superimposed on connective rather than on glandular tissue. In contrast, relatively large antral ulcers persisted for up to 80–100 days in more than 50% of the animals. A unique and characteristic histologic feature of the antral ulcer was the appearance of glandular cysts in the margin or base of the ulcerated area in the antrum. This experimental method appears suitable for screening therapeutic agents.

Cystic Degeneration of the Meibomian Glands

Relatively little attention has been given to the histopathologic alterations of the Meibomian glands, despite their functional importance and recognized participation in a large group of ocular disorders. Even this limited consideration has been focused on the tumors that may arise from these unique glandular structures, and very little emphasis has been given to the response of the Meibomian glands to obstruction by natural disease or surgical manipulation. An example of Meibomian cyst was described as early as 1875 by De Vincentiis, 1 and several subsequent reports of Meibomian gland obstruction and consequent cyst formation have appeared. 2-10 In general, these papers present isolated glandular cysts of variable size or refer to Meibomian gland obstruction and cyst formation secondary to trachomatous cicatrization of the lid. A number of recognized ophthalmic textbooks 11-14 mention the occurrence of Meibomian cysts and state that they may also result from congenital maldevelopment of the

Growth processes induced by estrogenic hormones in the uterus of the mouse.

In former investigations we have studied the growth processes which take place in the mammary gland (1) and in the vagina and cervix (2) of mice under the influence of estrogenic hormones, and the conditions under which these processes become cancerous. The investigations recorded here extend this analysis to the uterus of the mouse. By uterus, we understand that part of the vaginal-cervical-uterine tract which begins approximately at the point of bifurcation. In earlier studies on the guinea-pig, it was pointed out (3) that the cervix may be divided into three parts: a vaginal, an intermediate, and a uterine part. The condition is similar in the mouse, although in this animal the division is perhaps not quite so definite as in the guinea-pig. Also there exists in the mouse a transition zone between cervix proper and uterus, in which the tissue has essentially the structure of the uterus but still retains some cervical characteristics, namely, a somewhat greater tendency to the production of low squamous epithelium than is present in the uterus proper. Thus there may be found here an area in which are uterine glands covered by low squamous rather than by cylindrical epithelium; furthermore, there may develop in this area glandular cysts which are filled with hyaline nucleated cells instead of with a diffuse gelatinous material, such as is usually encountered in uterine cysts. In this transition zone the cysts may be lined entirely or partially with a low squamous epithelium.

Gelatinous Glandular Cysts of the Ovary, and the So-Called Pseudomyxoma of the Peritoneum

Gelatinous Glandular Cysts of the Ovary, and the So-Called Pseudomyxoma of the Peritoneum

On Gelatinous Glandular Cysts of the Ovary, and the so‐called Pseudomyxoma of the Peritoneum.*

On Gelatinous Glandular Cysts of the Ovary, and the so‐called Pseudomyxoma of the Peritoneum.*