Dealing with a giant ventral hernia can be a complex situation because it involves a considerable loss of space within the body. Although various surgical techniques are available for treating this condition, the recurrence rate remains high, making it challenging. This article presents a surgical treatment for a giant ventral hernia using synthetic mesh and a composite anterolateral thigh-tensor fasciae latae-vastus lateralis free flap. The average size of the hernia ring was 375.83 cm2, and all procedures were successful with minimal complications. After a follow-up period of 28 months, there have been no reports of recurrence. The technique is an effective option for treating patients with giant ventral hernias, particularly in cases where the component separation technique is not feasible.