Giant Phyllodes Tumor Research Articles

Coexistence of tuberculous axillary lymphadenitis and giant borderline malignant phyllodes tumor of the breast: A rare case report

Cystosarcoma phyllodes are uncommon breast tumors which rarely metastasize to axillary lymph nodes. The tumor is similar to fibroadenoma in structure, but it is different histologically. Although surgery (excision vs. mastectomy) is the mainstay of treatment, the need for adjuvant therapies such as radiotherapy for a malignant variety is unclear. Its association with ipsilateral tubercular axillary lymph nodes has not been reported in literature so far. We report a 35-year-old female that presented with a giant borderline malignant phyllodes tumor of the right breast along with ipsilateral tubercular granulomatous axillary lymph nodes.

Immediate Expander Implantation Following Simple Mastectomy of a Seven Kilograms Giant Phyllodes Tumor

We report a case of a 45-year-old Chinese-American woman with a giant phyllodes tumor measuring 29×27×22 cm. The patient relied on traditional Chinese medicine (TCM) and physical massage for more than one year before surgery. A simple mastectomy with immediate expander implantation was performed. During the surgery, a suspicious lymph node was found which might be related to breast massage. We kept superior and inferior skin flaps to cover the skin defect and reconstruct a breast shape one-stage operation.

Giant Recurrent Phyllodes Tumors of the Breast: Treatment Dilemmas and Literature Review

Giant Recurrent Phyllodes Tumors of the Breast: Treatment Dilemmas and Literature Review

Bilateral benign giant phyllodes tumor in an adolescent female: a rare case report

Cystosarcoma phyllodes or phyllodes tumor are rare fibroepithelial neoplasm accounting for only about 1% of the breast lesions in children and adolescents. Whether benign, borderline or malignant, they have high potential of recurrence. These biphasic tumors are having very low rate of bilateral occurrence and in that event they tend to be asynchronous. The definitive treatment of the benign entity is either wide local excision or mastectomy depending upon size and age of the patient. Ours is a case of 16 years old, orphan low socio-economic status female having bilateral giant phyllodes tumors that were confirmed on Fine needle aspiration cytology of both breasts. Wide local excision of the tumor could be done on the right side, and patient was discharged on 10 th post-operative day with advice to report after 6 weeks for possible surgery on the left enlarged breast. The histopathology report was consistent with the findings of benign phyllodes of the breast. Patient reported for the second surgery after 10 months of the first surgery and was subjected in wide local excision on the left side also. The case under report finds rarity due to its huge size, bilateral presentation in an unmarried adolescent female where the decision making regarding its definitive management becomes extremely difficult.

A giant phyllodes tumour with sepsis

A giant phyllodes tumour with sepsis

Mammaplasty using an inverted-T technique following the excision of a giant phyllodes tumor

We report the case of a woman with a giant phyllodes tumor who successfully underwent a mammaplasty after breast-conserving surgery (BCS). The patient was a 40-year-old woman with a 25-cm lump in the left breast. The lesion was diagnosed as a phyllodes tumor by core needle biopsy. The patient was informed about the risks and benefits of BCS and total mastectomy. She selected BCS, and a mammaplasty using an inverted-T technique was performed after the complete resection of the tumor. The skin was expanded, and the nipple–areola was transplanted as a free graft to achieve breast symmetry. The mass was histopathologically diagnosed as a benign phyllodes tumor. The patient was satisfied with the cosmetic results. This method is considered to be one of the options for the treatment of giant phyllodes tumors.

巨大乳腺葉状腫瘍の 1 例

44 歳，女性。約 10 年前より右乳房に腫瘤を自覚。その後徐々に増大し，表面に潰瘍形成を認めた。当科初診時には，最大径 24 cm ほどの巨大腫瘤となっており，表面に腫瘍が露出し多量の滲出液を伴っていた。造影 CT 上は腫瘍内に不規則な造影効果を認めたが，明らかな転移所見は認めなかった。生検にて葉状腫瘍が疑われ，右乳房腫瘍切除術および遊離分層植皮術を施行した。切除された腫瘤の重量は 3 kg であった。病理組織学的に，葉状腫瘍と診断した。乳腺葉状腫瘍は比較的稀な疾患であり，ときに急速な発育と巨大腫瘤化を認める。主に外科領域からの報告が多いが，皮膚の発赤・壊死・潰瘍形成などの症状を来した場合は初診時に皮膚科を受診することもある。本腫瘍の良性・悪性に関する生物学的性状については意見が分かれるところであり，腫瘍切除術後も再発に注意し慎重な経過観察が必要であると考える。

Recurrent Giant Phyllodes Tumour of the Breast Pathological Considerations and Management Approach for Recurrence and Metastasis

Phyllodes tumours are rare and account for 0.4% of all breast tumours. The majority of them tend to be less than 5 cms in size with giant tumours larger than 10 cms being about 20% of these cases. They display a broad range of clinical and pathological behavior and are regarded as falling within the spectrum of fibroepithelial neoplasms. Surgery has been the primary modality of treatment. However the extent of resection and the role of adjuvant radiotherapy and chemotherapy are still controversial. The risk of recurrence is (4.7% - 30%) for benign phyllodes tumour and (30% - 65%) for borderline and malignant phyllodes tumour. A case of giant phyllodes tumour measuring 36 × 30 cm and weighing 6.8 kg is presented, which had recurred following a previous resection 5 years back. The literature is reviewed with regards to pathology, the role of investigations, nature of resection and the risk factors for recurrence and metastasis

Giant phyllodes tumors of the breast: imaging findings with clinicopathological correlation in 14 cases

Purpose To describe imaging features in giant phyllodes tumors (GPTs) with radiology–pathologic correlations. Materials and Methods Surgically confirmed 14 GPTs of the breast were retrospectively reviewed with ultrasound, mammograms, computed tomography, magnetic resonance imaging, and positron emission tomography. Results The most GPTs showed circumscribed and lobulated masses with cystic necrosis. Five cases of core needle biopsy results were benign other than GPTs. Conclusion Radiology–pathologic correlation in GPTs is essential, due to differences of pathologic results (5/14 in our study) between core biopsy and surgical pathology.

Immediate latissimus dorsi pedicle flap reconstruction following the removal of an eight kilogram giant phyllodes tumour of the breast: a case report

IntroductionPhyllodes tumors account for less than 1% of breast tumors in women, and giant phyllodes tumors are those that are larger than 10 cm in diameter. Removal of such large tumors places a huge burden on the surgeon to reconstruct a breast that is aesthetically acceptable by the patient. We report what may be the largest giant phyllodes tumor and, most likely, the first latissimus dorsi flap used to cover such a large defect caused by the resection.Case presentationWe report the case of a 36-year-old Malaysian woman who presented with a three-year history of gradually increasing swelling of the left breast, with skin changes. Examination revealed a huge, globular, lobulated mass measuring 400 mm by 350 mm. The patient had a mastectomy with an immediate latissimus dorsi pedicled myocutaneous flap reconstruction. The breast weighed 8.27 kg, and ex vivo, the tumor measured 280 mm by 250 mm by 180 mm. Histopathologic analysis confirmed the diagnosis as a giant phyllodes tumor. At 12-month follow-up, the patient reports no complications and is satisfied with the aesthetic outcome.ConclusionGiant phyllodes tumors are very rare tumors that can reach up to 40 cm in diameter. Reconstruction of such a defect is a great challenge, and we report what we believe is the first latissimus dorsi flap to cover successfully a defect of approximately 400 mm by 350 mm.

A case of a giant phyllodes tumour of the breast

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Szrajda M, Szyca R, Jasiński A, Gryz M, Leksowski K. A case of a giant phyllodes tumour of the breast. Contemporary Oncology/Współczesna Onkologia. 2011;15(1):44-46. doi:10.5114/wo.2011.20531. APA Szrajda, M., Szyca, R., Jasiński, A., Gryz, M., & Leksowski, K. (2011). A case of a giant phyllodes tumour of the breast. Contemporary Oncology/Współczesna Onkologia, 15(1), 44-46. https://doi.org/10.5114/wo.2011.20531 Chicago Szrajda, Monika, Robert Szyca, Andrzej Jasiński, Marek Gryz, and Krzysztof Leksowski. 2011. "A case of a giant phyllodes tumour of the breast". Contemporary Oncology/Współczesna Onkologia 15 (1): 44-46. doi:10.5114/wo.2011.20531. Harvard Szrajda, M., Szyca, R., Jasiński, A., Gryz, M., and Leksowski, K. (2011). A case of a giant phyllodes tumour of the breast. Contemporary Oncology/Współczesna Onkologia, 15(1), pp.44-46. https://doi.org/10.5114/wo.2011.20531 MLA Szrajda, Monika et al. "A case of a giant phyllodes tumour of the breast." Contemporary Oncology/Współczesna Onkologia, vol. 15, no. 1, 2011, pp. 44-46. doi:10.5114/wo.2011.20531. Vancouver Szrajda M, Szyca R, Jasiński A, Gryz M, Leksowski K. A case of a giant phyllodes tumour of the breast. Contemporary Oncology/Współczesna Onkologia. 2011;15(1):44-46. doi:10.5114/wo.2011.20531.

Giant Phyllodes Tumor of the Right Breast in an 11-Year-Old Girl: A Report of a Case

Giant Phyllodes Tumor of the Right Breast in an 11-Year-Old Girl: A Report of a Case

Giant phyllodes tumor of the breast: a case report

Objective The aim of the study was to report a case with a giant phyllodes tumor of the left breast and discuss the diagnostic and management challenges.

Tumor phyllodes de mama

Phyllodes tumor is a rare fibroepithelial neoplasm of the breast, with unpredictable clinical behavior. We report a case of a giant phyllodes tumor (26×20 cm and 5.5 kg) of the left breast, which was treated by total mastectomy. Breast reconstruction was performed using a skin graft.

A case of a giant phyllodes tumor of the breast with hypoglycemia caused by high-molecular-weight insulin-like growth factor II

We report the case of a patient who presented with hypoglycemia associated with a giant breast mass and presence of serum high-molecular-weight insulin-like growth factor II (big IGF-II). In July 2005, a 49-year-old woman was admitted because of delirium, transient loss of consciousness, and a giant mass of about 28 cm in diameter on the right breast. She had noticed the mass for more than 2 years, but had refused medical attention at that time. A blood examination indicated hypoglycemia (21 mg/dl) and decreased levels of endogenous insulin. Furthermore, a western blot analysis revealed that big IGF-II (20 kDa) was the predominant serum IGF-II peptide (mature IGF-II is 7.5 kDa). Because we suspected that the big IGF-II was produced by the breast tumor and was likely the cause of the hypoglycemia, a mastectomy was performed. A histological examination determined that the mass was a benign phyllodes tumor. After surgery, the hypoglycemia resolved, and endogenous insulin levels improved. We suspected that the patient had non-islet cell tumor hypoglycemia (NICTH), but the behavioral symptoms of the hypoglycemia caused by NICTH were similar to some mental diseases, which made diagnosis based on the behavior alone difficult. We suggest that co-occurrence of symptoms such as recent appearance of mental disease-like behavior, hypoglycemia, and giant breast tumor may help diagnose NICTH caused by big IGF-II.

Surgical treatment of giant recurrent breast phyllodes tumor

In this study, a recurrent massive phyllodes tumor of the breast was surgically removed and the grafting was used to repair the local skin defects. A 29-y female patient had recurring breast phyllodes tumor of extremely large size in the chest wall after the excision of a previous tumor. The massive phyllodes tumor was eliminated by completely removing the layers of the skin and tissues above the costal bones with incisal margin being 2 cm away from the tumor lesion. The latissimus dorsi myocutaneous flap, lateral thoracic skin flap, and rectus abdominis myocutaneous flap were grafted to replace the lost tissues due to the surgery. Anti-infection and anticoagulation treatments were used after the surgery. The graft flaps had sufficient blood supply and good blood circulation, and the incisions mostly healed. The outcome of the surgery was acceptable. For the surgical treatment of the massive phyllodes tumor in the chest wall, it is an alternative of choice to use latissimus dorsi myocutaneous flap, lateral thoracic skin flap and rectus abdominis myocutaneous flap in combination for skin grafting.

Giant breast tumors: Surgical management of phyllodes tumors, potential for reconstructive surgery and a review of literature

BackgroundPhyllodes tumors are biphasic fibroepithelial neoplasms of the breast. While the surgical management of these relatively uncommon tumors has been addressed in the literature, few reports have commented on the surgical approach to tumors greater than ten centimeters in diameter – the giant phyllodes tumor.Case presentationWe report two cases of giant breast tumors and discuss the techniques utilized for pre-operative diagnosis, tumor removal, and breast reconstruction. A review of the literature on the surgical management of phyllodes tumors was performed.ConclusionManagement of the giant phyllodes tumor presents the surgeon with unique challenges. The majority of these tumors can be managed by simple mastectomy. Axillary lymph node metastasis is rare, and dissection should be limited to patients with pathologic evidence of tumor in the lymph nodes.

Giant phyllodes tumour of the breast

Phyllodes tumours are fibroepithelial lesions and count for 0.4% of breast tumours. Telling the difference between phyllodes tumours and fibroadenomas is sometimes difficult but of importance because wide resection is the mainstay of treatment for phyllodes tumours. We present a female patient, 55 years old with a giant phyllodes tumour (38 x 31 x 23 cm) of the breast. The breast reconstruction was done using a pedicled transverse rectus abdominis myocutaneous (TRAM) flap.

Tetanus caused by Ulcerated Giant Phyllodes Tumor

Tetanus is a rare infectious disease in western countries, however, it remains one of the most common and fatal disease in developing countries. Several diseases can mimic tetanus, and the diagnostic procedure is important to distinguish tetanus from other disease. Here we report the case of tetanus caused by ulcerated phyllodes tumor. This case suggests that the diagnosis and introduction of effective therapy should not be delayed, even if wound on the extremity surface is not clear.

Hypoglycemic Coma Secondary to Big Insulin-like Growth Factor II Secretion by a Giant Phyllodes Tumor of the Breast

Nonislet cell tumor hypoglycemia (NICTH) is uncommon, and has been related to the production of insulin-like growth factor II or its high-molecular-weight precursor (big IGF-II) by the tumor. Cases of NICTH have been related to different tumors, mainly sarcomas. However, only three cases secondary to a phyllodes tumor of the breast (PTB) have been previously reported. We present the clinical course of a woman with a giant PTB, who developed an irreversible hypoglycemic coma secondary to big IGF-II production by the tumor. A brief review of the literature and possible mechanisms of this infrequent condition are also commented.