Purpose: Choosing between an academic career and a private practice career is a difficult and critical decision for GI fellows. Many complex factors come into play when making this career choice. We conducted a nationwide survey of US GI fellows to identify key demographics and job-related factors to analyze this decision making process. Methods: A survey was emailed to all US GI Fellowship program directors and distributed at several fellows' endoscopy courses. Fellows filled out surveys via one of these two routes only. The survey queried respondents on their personal, educational, professional, and financial backgrounds and goals, and included a free response area where other factors could be addressed. No remuneration was offered for participants. Data was compiled and evaluated via univariate and multivariate analysis. Results: 184/404 (46%) US GI fellows submitted completed surveys. Univariate analysis identified one factor that predisposed fellows to pursue private practice: the perception that an academic salary would not meet their financial needs (p=0.04). Univariate analysis identified 4 factors that predisposed fellows to pursue academic practice: Age >35 years (p=0.003), prior attainment of a Master's degree (p=0.01), advanced fellowship training (p=0.0001), and a perception that academicians worked fewer hours (<60 per week) than private practice physicians (p=0.008). All of these factors except the perception regarding work hours were also statistically significant on the multivariate analysis. If salaries were equal, 108/131 (82%) fellows who answered the question would choose academic practice over private practice (p<0.0001). Fellows selecting academic practice were strongly motivated to publish and conduct research. The desire to teach was not a strong motivator for either group. Surprisingly, existing level of debt, the presence of a positive relationship with a mentor, and research experience were not significant factors in the decision. Conclusion: Salary plays a key role in the decision to pursue academic versus private practice, with those desiring more money strongly favoring private practice. Fellows choosing academic practice tended to be older, plan to pursue advanced training, desire fewer work hours per week, and appear to have a stronger preexisting academic background as evidenced by a high rate of prior graduate study. If salaries were equal in both academic medicine and private practice, the overwhelming majority (82%) of fellows would choose academic medicine.