Purpose The purpose of our study is to identify histopathologic sequelae and immunohistochemical changes that occur in the wall of the gastric fundus, antrum, and proximal duodenum after bariatric embolization—a procedure to suppress systemic levels of the hunger hormone, ghrelin, and modulate weight. Materials and Methods This post-necropsy study was performed on 12 swine stomach and duodenum specimens. 6 of the swine had previously undergone targeted bariatric embolization, and 6 other swine had undergone a sham procedure with saline. Gross pathologic examination of the stomach mucosa was performed post necropsy in all animals. In addition, contiguous tissue sections from 11 stomachs (fundus and antrum) and duodena were processed for HandE staining for histopathologic analysis. Mouse antighrelin IgG (Millipore, Billerica, MA) was used for immunohistochemical detection of ghrelin. Ghrelin-immunoreactive cell density was expressed as the average number of positive cells per high power field (400x, 0.49 mm field diameter). Results Histopathologic evaluation of treatment animals demonstrated mucosal ulceration in 2/6 (33%), and mild-moderate gastritis in 6 animals (100%). Control animals demonstrated mild-moderate gastritis in 5 animals (100%), with no ulceration. Ghrelin-immunoreactive mean cell density was significantly lower in the gastric fundus in the treatment animals 15.3, versus control animals, 22.0 (p=0.001). Ghrelin-immunoreactive mean cell density in the gastric antrum was similar in treatment animals, 9.3, versus control animals, 14.3 (p=0.075). Ghrelin-immunoreactive mean cell density in the duodenum was similar in treatment animals, 8.5, versus control animals, 8.6 (p=0.89). Conclusion Bariatric embolization can result in gastric mucosal ulceration as complications were seen in 33% of treated animals in the form of gastric ulcers, possibly due to non-target embolization. Immunohistochemical staining of the gastric fundi, antrums, and duodena confirms a significant reduction in the number of ghrelin-immunoreactive cell density in the gastric fundus after embolization. Furthermore, there is no compensatory upregulation of ghrelin-expressing cells in the gastric antrum or duodenum of treated animals.