This study offers a comprehensive analysis of the regulatory framework governing gold mining in Ghana, with a specific focus on Damongo, a rapidly growing mining hub in the Northern Region. Ghana's gold mining sector, a major contributor to the nation's economy, faces significant challenges despite its economic benefits. These challenges include severe environmental degradation, mercury contamination, and social issues exacerbated by inadequate regulatory enforcement. This article examines the existing regulatory framework, which includes key legislative acts such as the Minerals and Mining Act, 2006, and the Environmental Protection Agency Act, 1994, alongside a network of regulatory institutions like the Ministry of Lands and Natural Resources and the Minerals Commission. Utilizing Damongo as a case study, this research reveals critical inefficiencies in the local regulatory system, particularly in combating illegal mining activities and managing environmental and social impacts. Findings indicate that while gold mining has stimulated economic growth and provided employment opportunities, it has also led to negative consequences such as increased health problems, social vices, and reduced agricultural productivity. The study underscores the need for more robust regulatory practices, improved institutional capacity, and enhanced community involvement in environmental governance. Comparative insights from regulatory practices in other jurisdictions, such as Australia and Canada, highlight the potential benefits of adopting stricter environmental regulations, comprehensive impact assessments, and better coordination among regulatory agencies. The article concludes with recommendations for strengthening Ghana’s regulatory framework, including increased investment in regulatory institutions, improved enforcement mechanisms, and the promotion of sustainable mining practices. This study aims to contribute to the ongoing discourse on mining regulation and sustainability, providing actionable insights for policymakers and stakeholders involved in the governance of Ghana’s gold mining sector.