German Chemical Research Articles

GCC2011 – 25 years of computational chemistry meetings

25 years ago members of the Chemistry-Information-Computers (CIC) division of the German Chemical Society (GDCh) [1] realized that the usage of computers will play a major role in the processing of chemical information and that computational methods will have a large impact on chemical research approaches. At that time, Computational Chemistry was not yet established as a research field. Thus, scientists working in this area were typically chemists from all realms of chemistry who happened to have an interest in computers. To address the initial issues in the field of Computational Chemistry in a collaborative manner, the workshop “Software-Entwicklung in der Chemie” (software development in chemistry) — later renamed the CIC-Workshop — was established. The foundations were laid in this annual workshop and many projects and scientific outcomes originated from it in the years thereafter. While the initial workshops focused on the implementation of chemical databases, other topics, such as structure elucidation, structure representation and data mining, gained importance over the following years. The scientific network became more and more international over the intervening years, so much so that the CIC board decided in 2005 to change the, up to that point, German workshop into an international conference. The 7th German Conference on Chemoinformatics (GCC2011) was held from the 6th to the 8th of November 2011 in Goslar, Germany. The CIC division invited the chemoinformatics and molecular modeling community to the GCC2011 to celebrate the 25th anniversary of the CIC-workshop. The conference focused on recent developments and trends in the fields of Chemoinformatics and Drug Discovery Chemical Information, Patents and Databases Molecular Modeling Computational Materials Science and Nanotechnology As always, contributions from other research areas of Computational Chemistry were also welcome. Despite the recent major changes in the pharmaceutical industry and the resulting decrease in research, the number of participants was comparable to the German Conference on Chemoinformatics in 2010. The international character of the conference was even more pronounced than in the preceding years due to the 149 participants from 18 countries (Figure ​(Figure1,1, ​,22). Figure 1 149 participants from 18 countries and 5 continents attended the GCC2011. Figure 2 Participants of the 7th German Conference on Chemoinformatics (GCC2011), November 6 – 8, 2011 in Goslar, Germany. Following the tradition, the conference was opened up by the “Free-Software-Session” and the “Chemoinformatics Market Place” on Sunday afternoon. Four Open Source projects — Travis, Knime, ParadocS and DebiChem — were presented in the “Free-Software-Session” and three preconference workshops were given by the companies Chemical Computing Group, Tripos and Xemistry. The first day of the conference was concluded by dinner and an evening lecture by Johann Gasteiger (“25 Years of CIC – Achievements and Future Goals”) both of which took place in the ore mine of Rammelsberg. The program of the following two days included plenary lectures from six well-known keynote speakers from industry and academia (Oliver Kohlbacher, University of Tubingen, Germany; Colin Groom, CCDC, Cambridge, UK; Eva Rauls, University of Paderborn, Germany; Colin Batchelor, RCS, Cambridge, UK; Herbert Koppen, Boehringer Ingelheim, Germany and Xavier Barril, University of Barcelona, Spain), as well as 17 lectures and 71 poster presentations. A special highlight of the conference was the FIZ-CHEMIE-Berlin awards (Figure ​(Figure3).3). The CIC division awards this prize every year to the best diploma thesis and the best PhD thesis in the field of Computational Chemistry. The prize for the PhD thesis was awarded to Dr. Volker Hahnke from the group of Prof. Gisbert Schneider, ETH Zurich for his dissertation “Text-based Similarity Searching for Hit- and Lead-Candidate Identification”. The award for the best diploma thesis was given to Daniel Moser from the group of Jun. Prof. Eugen Proschak, University of Frankfurt for his excellent master thesis “Design of Dual Ligands Using Excessive Pharmacophore Query Alignment”. Due to the closedown of the FIZ CHEMIE Berlin, these prizes were awarded for the last time in 2011. To continue its support of young German scientists in the future, starting with the GCC2012, the CIC division will endow the “CIC Advancement Award for Computational Chemistry”. Figure 3 FIZ CHEMIE Berlin Awards 2011: from left to right, Rene de Planque (Head of the FIZ CHEMIE Berlin), Volker Hahnke (FIZ CHEMIE Berlin awardee, dissertation prize; NCBI, Bethesda, USA), Daniel Moser (FIZ CHEMIE Berlin awardee, master thesis prize; ... The conference ended on Tuesday evening with a conference dinner and a speaker who was announced as a “special guest from MIT”. The special guest turned out to be Thomas Fraps, a magician who presented a very entertaining show. In the end he left a pleased and puzzled audience who could not find the answers to his “scientific experiments”. A lot of problems in Computational Chemistry have been solved in the last 25 years, yet the road ahead is full of challenging issues waiting to be tackled.

25 years of CIC – achievements and future goals

25 years ago several persons within the German Chemical Society realized that computer methods will increasingly play a major role in the processing of chemical information. This led to the foundation of the Division “Chemie-Information-Computer (CIC)” and the establishment of a Workshop “Software-Entwicklung in der Chemie”, Parallel to this meeting the “Molecular Modeling Workshop” was initiated covering more the fields of molecular modeling and drug design. Over the years the CIC Workshop embraced the English language and metamorphosed into a European endeavor. From the very beginning scientists of all disciplines of chemistry participated in this Workshop. Initially, a major emphasis was put on the building of databases paralleling the work on the Beilstein, the Gmelin, the SpecInfo and the ChemInform databases. However, already in the early phases of this Workshop research was presented on converting chemical information into knowledge and using this knowledge in systems for automatic structure elucidation or the design of organic syntheses. The Workshop certainly was instrumental in introducing Chemoinformatics in Germany. Many problems in Chemoinformatics were tackled and solved. However, it must be realized that by far not all problems have been solved. Furthermore, the recognition of Chemoinformatics as a scientific discipline still leaves something to be desired. These topics will be discussed and approaches for their improvement will be outlined.

Washing at Low Temperatures – Saving Energy, Ensuring Hygiene

The Colloquium “Washing at Low Temperatures” was jointly organised by the Division of Detergency and Formulations of the German Chemical Society (Gesellschaft Deutscher Chemiker – GDCh) and the FORUM WASCHEN on October 28, 2011, and hosted in the DECHEMA complex in Frankfurt (Main). Eight lectures and intense discussions covered energy saving by washing at low temperatures, the performance of enzymes and bleach systems at low temperatures as well as detergent formulations for low temperature laundering. Furthermore, hygiene and biofilms in washing machines, the reduction of germs and the hygiene of laundry were presented. The welcome address was given by the Chairman of the GDCh Division, H.-D. Speckmann.

To Professor Wolfgang Beck on the Occasion of his 80thBirthday

Wolfgang Beck, professor emeritus of the LudwigsMaximilians-Universitat Munchen celebrated his 80th birthday on May 5th, 2012. Wolfgang Beck is an alumnus of the Technische Hochschule Munchen where he obtained his Dr. rer. nat. degree in 1960 with Walter Hieber. In 1968 he moved to the then nearby Ludwigs-MaximiliansUniversitat to become a full professor of chemistry. Despite offers from the Universities of Marburg and Hamburg he has remained in Munich ever since, a remarkable example of the Benedictine stabilitas loci. Since 2000 Wolfgang Beck has been a professor emeritus. Wolfgang Beck is known for his numerous contributions to inorganic and organometallic coordination chemistry. Being a prolific writer, his ample work is documented in more than 600 publications. He has been awarded a Karl-Winnacker Fellowship (1966), the Chemistry Prize of the Gottinger Akademie der Wissenschaften (1967) and the Liebig-Denkmunze of the German Chemical Society (1994). In 2011 his alma mater, the Technische Universitat Munchen, awarded Wolfgang Beck the honorary doctorate, the Dr. rer. nat. h. c. degree. Wolfgang Beck always has been, and still is, a frequent contributor to Zeitschrift fur Naturforschung B: Chemical Sciences. Reflecting his long-term special interest in Bioinorganic Chemistry, as recently as 2009 he reviewed the role of metal atoms as protective groups of amino acids and peptides in this journal. We, the editors, publishers and the editorial team would like to express our gratitude to Wolfgang Beck for his numerous achievements in chemistry and his ongoing service to the scientific community. We do so together with the friends, former students and colleagues who contributed to this special issue of Zeitschrift fur Naturforschung dedicated to Wolfgang Beck. Ad multos annos!

Environmental surveys, specimen bank and health related environmental monitoring in Germany

Production of chemicals, use of products and consumer goods, contamination of food as well as today's living conditions are related to a substantial exposure of humans to chemicals. Safety of human beings and the environment has to be safeguarded by producers and government. Human biomonitoring (HBM) has proven to be a useful and powerful tool to control human exposure and facilitate risk assessment. Therefore, the German Federal Environment Agency (Umweltbundesamt, UBA) employs two major HBM tools, the German Environmental Survey (GerES) and the German Environmental Specimen Bank (ESB). GerES is a nationwide population representative study on HBM and external human exposure, which has, inter alia, been used to identify lead in tap water, lead dustfall, time spent in traffic, and age of dwelling as exposure sources for lead and, thus, to derive risk reduction measures. The ESB is a permanent monitoring instrument and an archive for human specimens. Retrospective monitoring of phthalates and bisphenol A provides a continuous historical record of human exposure in Germany, over the last decades. Additionally it revealed that estimations of human exposure based on production and consumption data may supply misleading information on human exposure. HBM data demonstrated that (a) the use if the restricted isomer di-n-butylphthalat decreased while di-i-butylphthalate levels remained constant and (b) human bisphenol A exposure might be overestimated without monitoring data. The decrease of polycyclic aromatic hydrocarbon-exposure proves the success of German environmental policy after German re-unification. In addition to GerES and ESB UBA is involved in different co-operation networks, the two most prominent of which are (1) the harmonization of HBM in Europe (ESBIO; Expert Team to Support Biomonitoring in Europe, COPHES/DEMOCOPHES; Consortium to Perform Human Biomonitoring on a European Scale/Demonstration of a study to Coordinate and Perform Human Biomonitoring on a European Scale) and (2) the co-operation between BMU and the German Chemical Industry Association (VCI). In the latter project emphasis will be placed on substances with a potential relevance for health and on substances to which the general population might potentially be exposed to a considerable extent and for which HBM methods are not available up to now.

Editorial: Fundamental Research Needs Excellent Scientists and its Own Space

Editorial: Fundamental Research Needs Excellent Scientists and its Own Space

Article Series: Communications from the division "Environmental Chemistry and Ecotoxicology" of the German Chemical Society (GDCh) -Statements and reports of the working groups "Environmental Monitoring" and "Soil Chemistry and Soil Ecology"

Abstract A continuous task of the working group "Environmental Monitoring" is the development of methods and guidelines for a systematic and long-term analytical control of the chemical burden of environmental compartments and biota A new recommendation regarding the substance-related environmental monitoring is published in "Environmental Science and Pollution Research" (Rüdel et al., 2009). The "Chemical and Biological Monitoring Series", published in the same journal, originates from the working group or from its individual members also. Some central points of these articles are picked up and updated in this report. Current topics of major concern are the transformation of pharmaceuticals and its consequences for environmental monitoring and the monitoring of biocides and nanoparticles. Besides other objectives the working group "Soil Chemistry and Soil Ecology" focuses on the development and standardisation of methods for the chemical, physical, and biological characterisation of soil pollution by specific contaminants as well as on the elaboration of methods for the assessment of potential harmful effects on soil, soil ecology, and on other potentially targeted environmental media. Recently the working group has summarized its main outcomes and conclusions in the position paper "Target Orientated Exposition Estimation in Soil Assessment" which is part of this report. Furthermore several other initiatives and activities of the working group are presented.

4th Joint Annual Meeting of SETAC GLB and GDCh-Working Group "Environmental Chemistry and Ecotoxicology" held under the main theme "From insight to decision (making)" from 6th to 9th September 2010 in Dessau-Rosslau

This report provides a brief review of the fourth joint meeting of the German Language Branch of Society of Toxicology and Chemistry (SETAC GLB) and the Working Group Environmental Chemistry and Ecotoxicology of the German Chemical Society (GDCh) held from 6th to 9th of September 2010 at the Federal Environment Agency (UBA) in Dessau-Rosslau (Germany). For the first time a governmental institution was responsible for the local organization, a novelty that was expressed in the meeting's main theme From insight to decision (making). 366 participants discussed 105 oral and 125 poster presentations and three invited key speakers from government, academia and industry. The best oral and poster presentations of the meeting were awarded. Moreover, the annual young scientist award of SETAC GLB for the best diploma and doctoral thesis and the best publication award of the GDCh-Working Group Environmental Chemistry and Ecotoxicology were officially handed over. The reader of the meeting (mostly in German language) including the meeting program and all abstracts is for free available via: http://www.setac-glb.de

Financial Research Support for Ecotoxicology and Environmental Chemistry in Germany - Results of an Online Survey

In recent years several initiatives addressed the inadequate financial support of pollutant-related environmental research in the Federal Republic of Germany. For an objective analysis about the research funding in ecotoxicology and environmental chemistry in Germany, an anonymous online survey was prepared. With support of the Society of Environmental Toxicology and Chemistry (SETAC) - German Language Branch and the German Chemical Society (GDCh) - Division of Environmental Chemistry and Ecotoxicology an invitation to participate in the survey was sent to all members of these two major associations for ecotoxicology and environmental chemistry in Germany (D), Switzerland (CH) and Austria (A). Only senior staff from the areas academics, government and industry was invited. The present article introduces the results of the survey. It is segmented in a section on socio-economic characterization of the participants, a section on support of research by the DFG and a section on funding by other funding organizations. A total of 71 male and female scientists in senior positions from various areas participated in the survey. The results revealed that the participants are to be classified as having excellent records. 48.5% of the respondents had submitted at least one research proposal to the DFG in the past, but one third actually received financial support by the DFG. 64% are not satisfied with the DFG support of pollutant-related research, only 7% are satisfied. It turned out that the research proposals are generally very heterogeneous and thus distributed to various units of the DFG with geosciences, water research and chemistry ranking highest, followed by biology and ecology. 91.2% of the respondents indicated that they have submitted proposals for research funding to other funding institutions (except the DFG), and 83.6% already have received appropriate external funding. 62.3% of the scientists believe that overall support for chemicals-related research in recent years has significantly deteriorated or is deteriorating. The vast majority of respondents (60.9%) is dissatisfied with the funding situation, only 10.9% are satisfied. When asked Is the total research funding in other European countries superior to that in Germany? 30% answered yes, 9% answered no and 61% do not know. In summary the survey shows that the funding situation for research in ecotoxicology and environmental chemistry in Germany is improvable, and with respect to the DFG it is considered problematic. The noticeable under-representation of the DFG in comparison to other funding institutions shows that the most important funding body in Germany does not take into account the requirements of pollutant-related environmental sciences. In particular the answers to the open questions regarding improvement of research funding should be used as a basis for an open dialogue of chemicals-related environmental research institutes with the funding institutions DFG, BMBF and DBU and corresponding institutions in CH and A.

Hans Georg von Schnering 1931–2010

Hans Georg von Schnering 1931–2010

Angewandte Chemie International Edition Celebrates Its 50th Birthday

Angewandte Chemie International Edition Celebrates Its 50th Birthday

German Conference on Chemoinformatics 2010 – organizers' notes

The Chemistry-Information-Computers (CIC) division [1] of the German Chemical Society (GDCh) invited the chemoinformatics and modeling community from the 7th to the 9th November 2010 to Goslar, Germany, to participate in the 6th German Conference on Chemoinformatics (GCC 2010). The international symposium addressed a broad range of modern research topics in the realm of computers and chemistry. The conference focused on recent developments and trends in the fields of • Chemoinformatics and Drug Discovery • Chemical Information, Patents and Databases • Molecular Modeling • Computational Material Science and Nanotechnology In addition, contributions from other research areas of Computational Chemistry were welcome. Similar to other conferences in the Life Science sector the German Conference on Chemoinformatics was faced with a decreasing number of participants in 2010. This is assumed to be mainly caused by travel cost cuts in industry due to the global economic crisis. Nevertheless, a large number of scientists (156 participants, Figure ​Figure1)1) from 18 nations were attracted by the excellent scientific program established by the scientific advisory board and attended the GCC 2010. The large number of attendees from countries other than Germany demonstrates that the conference is an internationally well-established event in the global Chemoinformatics and Modelling community (see Figure ​Figure2A).2A). Despite the travel situation in industry, a good ratio between academic institutes, industry and exhibitors could be achieved (see Figure ​Figure2B2B). Figure 1 Participants of the 6. German Conference on Chemoinformatics, November 7–9, 2010, Goslar, Germany. Figure 2 A) 156 participants from 18 nations attended the GCC2010. Most participants (99) were from Germany followed by 16 attendees from the United Kingdom. Participants from the USA and Switzerland followed on the third position with 6 attendees each. B) 56% ... Traditionally, the conference was opened by a “Free-Software-Session” on Sunday afternoon right before the official conference opening at 5 pm. Six Open Source projects were presented in “Free-Software-Session”. This was the largest number of contributions to this session in the history of the GCC. The audience followed presentations of PostgreSQL (Bayer Business Services), OCHEM (Helmholtz Zentrum Munchen), Knime (University of Konstanz), Indigo & Ketcher (SciTouch), and MosGrid (MosGrid Consortium). The “Chemoinformatics Market Place” took place at the same time and included software tutorials by the Chemical Computing Group (“New Features of MOE 2010”) and BioSolveIT (“Fragment-Based Lead Design in Teams”). The scientific program started with an entertaining and enthralling evening lecture giving by Colleen Fitzpatrick (“Hand in Snow”). In addition, the program of the following two days included plenary lectures of six well known invited speakers from industry and academia (Wolfgang Guba, Roche, Swiss; Andrew R. Leach, GSK, UK; Hans Fraaije, Leiden University, The Netherlands; Jurgen Gmehling, Oldenburg University, Germany; Gerhard Klebe, Marburg University, Germany; Holger Gohlke, Dusseldorf University, Germany), 17 lectures as well as 43 poster presentations. Besides the scientific program a special highlight of the conference were the awards (see Figure ​Figure3).3). In contrast to the last GCC in 2009, two different awards could be handed over for excellent scientific work this year. Prof. Jurgen Gmehling from the University of Oldenburg was presented with the Gmelin-Beilstein-Denkmunze [2] award for his groundbreaking contributions in the field of compound databases and fragment methods for the prediction of chemical properties used in technical chemistry. The laudatory speech was given by Prof. Onken and the award was handed over by the president of the German Chemical Society Prof. Michael Droscher. Furthermore, the FIZ-CHEMIE-Berlin awards [3] took place on Monday afternoon. The CIC division awards this price each year to the best diploma thesis and the best PhD thesis in the field of Computational Chemistry. The price for the PhD thesis was awarded to Dr. Simone Fulle from the group of Prof. Dr. Holger Gohlke, Goethe University of Frankfurt for her dissertation “Constraint counting on RNA and ribosomal structures: Linking flexibility and function”. The award for the best diploma thesis was given to Karen Schomburg from the group of Prof. Matthias Rarey, University of Hamburg for her excellent master thesis with the title “Visualization of molecular subgraph pattern using the example of SMARTS pattern”. Figure 3 FIZ CHEMIE Berlin Awards 2010 and GDCh Gmelin-Beilstein-Denkmunze Award: from left to right, Frank Oellien (Chair of the GDCh-CIC division), Ulfert Onken (Laudatory Gmelin-Beilstein-Denkmunze Award), Karen Schomburg (FIZ CHEMIE Berlin ...

GDCh-Intensive Course Surfactants: Detergents, Cosmetics, Technical Applications

For many years the training programme of the German Chemical Society GDCh did not contain a training course on surfactants although both production and use of surfactants play a major role in Germany and interest was there from diverse sides. The sector group “Detergents” (Fachgruppe Waschmittelchemie) of GDCh was recently asked to provide such a course. After setting up a one-day course in Idstein under guidance of Professor Dr. Thomas Knepper and with contributions from experts from the Fachgruppe Waschmittelchemie in 2009 and 2010, the high interest in this event allowed the GDCh to establish a more intense two day course which covers the full spectrum of surfactant technologies including the Personal Care area. This was realised in September 2010 in Essen in the premises of Evonik Goldschmidt GmbH with a broad participation of leading scientists from surfactant research and specialists from the organising company. The participation in this course was again excellent. The participants from Germany and Switzerland came from diverse companies who produce or use surfactants. On day 1, after the welcoming words of Dr. Stefan Silber, Head of the Innovation Management and R & D of Evonik’s Business Unit Consumer Specialties and Dr. Felix M ller, Evonik Goldschmidt GmbH as the organizer of the training course, Professor Dr. Heinz Rehage from Technical University Dortmund started with the general introduction on surfactants and adressed phenomena like micells, CMC and did progress very quickly into the details of modern rheology and the options to study surfactant behaviour in detail making vesicles and liposomes visible and understandable. He went into video-enhanced contrast microscopy, NMR-spectroscopy and isothermal titration calometry as means to visualize surfactant properties. Prof. Dr. Cosima Stubenrauch from Stuttgart University continued with a detailed introduction into the secrets of emulsions and microemulsions, their applications and analytics. She addressed stability issues of emulsions as well as modern technologies like PIT emulsions and went thoroughly through the unique world of microemulsions and their special features. The stability of microemulsions was explained and their special phase diagrams. The third presentation was given by Dr. Peter Schmiedel from Henkel KGaA, who described in depth the current composition of the diverse laundry detergent products on the market, from European powder liquid systems to fabric softeners and special detergents for wool, black fabrics etc. He detailed the mechanisms of bleaching and dye transfer inhibition. He explained as well the actions and synergisms of various ingredients and gave an outlook for the further development of the laundry detergents in different parts of the world. Professor Dr. Thomas Knepper from Fresenius University in Idstein gave his insights into the special problems of surfactant analytics and explained the special environmental background of the fate of surfactants that will be usually intentionally released into wastewater and explained with examples from the Philippines what consequences the use of nonbiodegradable surfactants has for ground water pollution. He focussed as well especially on fluorinated surfactants and the approaches to avoid the bioaccumulation of these materials. Dr. Bernd Glassl from Industrieverband Kosmetik und Waschmittel (IKW, German industry group cosmetics and detergents) in Frankfurt gave finally on the first day an introduction into the special legal situation of surfactants in laundry and cosmetics, a field where European and German law contributes to a lot of details to observe when formulating products. He explained the different biodegradation test protocols and their respective use in different directives. The discussion of the contributions added value for the participants as fairly detailed questions and problems were well solved and addressed by the presenters. On the second day, it was Dr. Joachim Venzmer of Evonik Goldschmidt GmbH, Essen, who started with a presentation on silicone surfactants. He addressed properties and technical applications of this interesting surfactant class far beyond what is found in text books and explained state of art superspreading technology for agricultural applications as well as wetting and release coating, paint wetting and spreading of cosmetic oil explained some of the unique features of silicone surfactants. Dr. Sascha Herrwerth of Evonik Goldschmidt GmbH continued with a presentation on Rinse-Off cosmetic for hairand body cleansing, detailing formulas and explaining effects and properties which are under demand by consumers like foaming, mildness, conditioning and the demands which arise from new ingredients in Personal Care formulations. A special focus was on conditioning agents for shampoos as well as conditioning rinses to be used after washing the hair. The proper viscosity control was addressed as well and how to avoid the problems for rinse-off products at elevated temperatures (the sport-bag-effect). CONFERENCE AND MEETING REPORT

German Initiative to Support Human Biomonitoring: Co-operation Project Between the German Chemical Industry Association and the Federal Ministry for The Environment, Nature Conservation and Nuclear Safety

O-30B3-3 Background/Aims: The German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU) and the German Chemical Industry Association e. V. (VCI) representing over 90% of the German chemical industry agreed to work on the goal to increase the knowledge on the internal exposure to chemicals of the general population. The Federal Environment Agency will play a vital role in this cooperation. Emphasis will be placed on substances with either a potential health relevance or to which the general population might potentially be exposed to a considerable extent. Methods: Markers to investigate population's internal exposure to chemicals by human biomonitoring (HBM) will be identified and new analytical methods will be developed. It is planned to work on 50 chemicals during 10 years with a 3-year pilot phase after which the project will be evaluated. The work is supported by an advisory panel consisting of scientists from academia, industry, and administration. Strategic decisions will be made by a management committee including representatives from industry, the Ministry, and the Agency. Results: VCI agreed to take over the responsibility and the funding for developing the new HBM methods, BMU for applying them in population-based HBM studies. Thus, separate responsibilities and promises of financing were arranged. Communication of project-related issues will be done after consultation of the respective project partner. An initial list of potential substances has already been prepared. It was agreed to publish the resulting chemical-analytical methods and exposure data in scientific journals. Conclusion: The agreement was signed in February 2010. Based on the advice of the scientific panel, the management committee will decide in May 2010 upon the first 5 substances to start with. Substances were proposed by the advisory panel. This project will contribute to a realistic estimation of internal exposure to relevant chemicals in the German population.

50 Years of the International Edition: More Substance than Appearance

50 Years of the International Edition: More Substance than Appearance

ChemInform Abstract: Aziridinyl Anions: Generation, Reactivity, and Use in Modern Synthetic Chemistry

AbstractReview: 178 refs.

ACS-GDCh ALLIANCE

RETURN TO ISSUEPREVACS NewsNEXTACS-GDCh ALLIANCEAmerican and German Chemical Society agree to undertake joint activities to COMMUNICATE CHEMISTRY’S VALUEMADELEINE JACOBSCite this: Chem. Eng. News 2010, 88, 38, 33Publication Date (Print):September 20, 2010Publication History Published online27 March 2011Published inissue 20 September 2010https://doi.org/10.1021/cen-v088n038.p033Copyright © 2010 AMERICAN CHEMICAL SOCIETYArticle Views69Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (522 KB) Get e-Alerts

Nürnberg: A Showcase for European Chemistry

Nürnberg: A Showcase for European Chemistry

Managing strategic alliances through a community‐enabled balanced scorecard: The case of Merck Ltd, Thailand

AbstractCorporations often engage in corporate community involvement (CCI) in order to improve the social and environmental conditions in their local communities. Firms also become involved in strategic alliances with non‐governmental organizations (NGOs) to guarantee that the initiatives are meaningful. At the same time, such alliances strengthen business impacts resulting from employee and customer proximity to CCI, which is defined as the awareness of, perceived credibility of, and active involvement in CCI activities. Though these effects are strategically relevant, strategic alliances for CCI mostly remain separate from corporate strategy. We propose the community‐enabled balanced scorecard (CBSC) as a conceptual framework for integrating both community and business goals in the strategic management of the firm. We use a case study research approach covering qualitative interviews and action research at Merck Ltd, Thailand, a subsidiary of a large German chemical and pharmaceutical corporation, to demonstrate the practicability of the framework. Copyright © 2010 John Wiley & Sons, Ltd and ERP Environment.

BIOMONITORING German industry, government join over methods to assess chemical risks

In an unusual cooperative effort between industry and government, the German Chemical Industry Association, known as VCI, has undertaken a 10-year program to develop analytical methods to detect up to 50 industrial chemicals in people. The German Federal Ministry for the Environment, Nature Conservation & Nuclear Safety will use the detection methods to conduct biomonitoring studies and determine risks to human health. Government agencies typically develop their own methods to detect chemicals in blood and urine, consulting with industry scientists only when they need additional expertise, says Sean M. Hays, president of Allenspark, Colo.-based Summit Toxicology. But the emergence of a biomonitoring collaboration is a step in the right direction, he says. Hays consults for both industry and government, and his firm has developed computational technology to interpret biomonitoring test results (C&EN, Jan. 28, 2008, page 52). “Human biomonitoring can serve as an early-warning system” on the buildup of subst...