Georgia Medical Research Articles

A novel role for activating transcription factor-2 in 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis

To investigate the mechanisms underlying 15(S)-HETE-induced angiogenesis, we have studied the role of the small GTPase, Rac1. We find that 15(S)-HETE activated Rac1 in human retinal microvascular endothelial cells (HRMVEC) in a time-dependent manner. Blockade of Rac1 by adenovirus-mediated expression of its dominant negative mutant suppressed HRMVEC migration as well as tube formation and Matrigel plug angiogenesis. 15(S)-HETE stimulated Src in HRMVEC in a time-dependent manner and blockade of its activation inhibited 15(S)-HETE-induced Rac1 stimulation in HRMVEC and the migration and tube formation of these cells as well as Matrigel plug angiogenesis. 15(S)-HETE stimulated JNK1 in Src-Rac1-dependent manner in HRMVEC and adenovirus-mediated expression of its dominant negative mutant suppressed the migration and tube formation of these cells and Matrigel plug angiogenesis. 15(S)-HETE activated ATF-2 in HRMVEC in Src-Rac1-JNK1-dependent manner and interference with its activation via adenovirus-mediated expression of its dominant negative mutant abrogated migration and tube formation of HRMVEC and Matrigel plug angiogenesis. In addition, 15(S)-HETE-induced MEK1 stimulation was found to be dependent on Src-Rac1 activation. Blockade of MEK1 activation inhibited 15(S)-HETE-induced JNK1 activity and ATF-2 phosphorylation. Together, these findings show that 15(S)-HETE activates ATF-2 via the Src-Rac1-MEK1-JNK1 signaling axis in HRMVEC leading to their angiogenic differentiation.

Psychiatrists Proactive in Scope-of-Practice Battles

Psychiatrists Proactive in Scope-of-Practice Battles

Cutting-edge Discussions of Management, Policy, and Program Issues in Emergency Care

Cutting-edge Discussions of Management, Policy, and Program Issues in Emergency Care

A Survey of Knowledge and Attitudes about HIV and AIDS among Medical Students

Click to increase image sizeClick to decrease image size Additional informationNotes on contributorsJ. Stephen McDanielJ. Stephen McDaniel, MD is an assistant professor of psychiatry and behavioral sciences with the Emory Clinic of the Emory University School of Medicine in Atlanta, Georgia; Lisa M. Carlson is Provider Outreach Coordinator of the Georgia Medical Care Foundation in Atlanta; Nancy J. Thompson is an assistant professor of behavioral sciences and epidemiology at the Emory University School of Public Health; and David W. Purcell is a doctoral candidate in the Department of Psychology at Emory.Lisa M. CarlsonJ. Stephen McDaniel, MD is an assistant professor of psychiatry and behavioral sciences with the Emory Clinic of the Emory University School of Medicine in Atlanta, Georgia; Lisa M. Carlson is Provider Outreach Coordinator of the Georgia Medical Care Foundation in Atlanta; Nancy J. Thompson is an assistant professor of behavioral sciences and epidemiology at the Emory University School of Public Health; and David W. Purcell is a doctoral candidate in the Department of Psychology at Emory.Nancy J. ThompsonJ. Stephen McDaniel, MD is an assistant professor of psychiatry and behavioral sciences with the Emory Clinic of the Emory University School of Medicine in Atlanta, Georgia; Lisa M. Carlson is Provider Outreach Coordinator of the Georgia Medical Care Foundation in Atlanta; Nancy J. Thompson is an assistant professor of behavioral sciences and epidemiology at the Emory University School of Public Health; and David W. Purcell is a doctoral candidate in the Department of Psychology at Emory.David W. PurcellJ. Stephen McDaniel, MD is an assistant professor of psychiatry and behavioral sciences with the Emory Clinic of the Emory University School of Medicine in Atlanta, Georgia; Lisa M. Carlson is Provider Outreach Coordinator of the Georgia Medical Care Foundation in Atlanta; Nancy J. Thompson is an assistant professor of behavioral sciences and epidemiology at the Emory University School of Public Health; and David W. Purcell is a doctoral candidate in the Department of Psychology at Emory.

South Georgia Medical Center

South Georgia Medical Center

The role of the nurse clinician in hypertension compliance: Emphasis on communication skills: Judy Jones, West Georgia Medical Center, LaGrange, Georgia, William M. McClellan, Clark-Holder Clinic, LaGrange, Georgia

The role of the nurse clinician in hypertension compliance: Emphasis on communication skills: Judy Jones, West Georgia Medical Center, LaGrange, Georgia, William M. McClellan, Clark-Holder Clinic, LaGrange, Georgia

Improved HBP control in a semi-rural hypertension compliance clinic: Suggested strategies: William M. McClellan, Clark-Holder Clinic, LaGrange, Georgia, Judy Jones, West Georgia Medical Center, LaGrange, Georgia

Improved HBP control in a semi-rural hypertension compliance clinic: Suggested strategies: William M. McClellan, Clark-Holder Clinic, LaGrange, Georgia, Judy Jones, West Georgia Medical Center, LaGrange, Georgia

Some Biological Applications of High Voltage Electron Microscopy

The High Voltage Electron Microscope Laboratory at the University of Wisconsin has been in operation a little over one year. I would like to give a progress report about our experience with this new technique. The achievement of good resolution with thick specimens has been mainly exploited so far. A cold stage which will allow us to look at frozen specimens and a hydration stage are now being installed in our microscope. This will soon make it possible to study undehydrated specimens, a particularly exciting application of the high voltage microscope.Some of the problems studied at the Madison facility are: Structure of kinetoplast and flagella in trypanosomes (J. Paulin, U. of Georgia); growth cones of nerve fibers (R. Hannah, U. of Georgia Medical School); spiny dendrites in cerebellum of mouse (Scott and Guillery, Anatomy, U. of Wis.); spindle of baker's yeast (Joan Peterson, Madison) spindle of Haemanthus (A. Bajer, U. of Oregon, Eugene) chromosome structure (Hans Ris, U. of Wisconsin, Madison). Dr. Paulin and Dr. Hanna are reporting their work separately at this meeting and I shall therefore not discuss it here.

Sacrococcygeal Chordoma

1Baltimore, Maryland 2Augusta, Georgia From the Surgical Services of the U. S. Veterans Hospital at Perry Point, Maryland, the U. S. Veterans Hospital, Forest Hills Division, at Augusta, Ga., and from the Surgical Department of the Johns Hopkins Medical School, Baltimore, and of the University of Georgia Medical School, Augusta.

Book Review The Hall of the Georgia Medical Society . By J. Ewing Mears, M.D., LL.D. Philadelphia: Dornan. 1914.

Book Review The Hall of the Georgia Medical Society . By J. Ewing Mears, M.D., LL.D. Philadelphia: Dornan. 1914.

Résumé of a Report on Position, Pneumatic Pressure, and Mechanical Appliance in Uterine Displacement, read before the Georgia Medical Association of Savannah, April 23,1875

Résumé of a Report on Position, Pneumatic Pressure, and Mechanical Appliance in Uterine Displacement, read before the Georgia Medical Association of Savannah, April 23,1875

Superior Court, Eastern District of Georgia. State of Georgia Ex Relatione James J. Waring v. The Georgia Medical Society

Superior Court, Eastern District of Georgia. State of Georgia Ex Relatione James J. Waring v. The Georgia Medical Society